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Nutrients
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Nutrition for Patients with Diabetes and Clinical Obesity
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Nutrition for Patients with Diabetes and Clinical Obesity

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Diabetes".

Deadline for manuscript submissions: closed (15 May 2025) | Viewed by 4688

Special Issue Editors

Dr. Sin-Chung Li

E-Mail Website
Guest Editor
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
Interests: nutrigenomics; nutrition and metabolism; nutrition and food science; bioactive compounds for diabetes
Special Issues, Collections and Topics in MDPI journals
Dr. Chiao-Ming Chen

E-Mail Website
Guest Editor
Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei 10462, Taiwan
Interests: clinical nutrition; early childhood nutrition; health food; efficacy evaluation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of the Nutrition and Diabetes section focuses on the genetic etiology, nutrition and metabolism, clinical nutrition, and efficacy evaluation of health foods related to diabetes and obesity. We welcome researchers to submit original research articles, reviews, and clinical studies that align with these specialties and contribute to advancing our understanding in these critical areas. This Special Issue highlights innovative nutritional strategies and interventions aimed at effectively managing and treating both diabetes and obesity, which are prevalent and growing health concerns worldwide. Topics include but are not limited to the impact of bioactive compounds on the metabolic health of diabetes and obesity, personalized nutrition approaches tailored to individual needs, development and assessment of health foods designed for these conditions, and dietary recommendations for children with diabetes. We particularly encourage submissions that explore the molecular mechanisms of nutrition in diabetes and obesity, as well as practical applications for improving patient care and outcomes, thus bridging the gap between research and clinical practice.

Dr. Sin-Chung Li
Dr. Chiao-Ming Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetic etiology
  • nutrition and metabolism
  • clinical nutrition
  • health food efficacy
  • diabetes
  • obesity
  • bioactive compounds
  • personalized nutrition

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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16 pages, 1413 KiB  
Article
Feasibility of a Structured Calorie-Restricted Dietary Intervention in Korean Adults with Early Type 2 Diabetes and Obesity: A Pilot Study
by Su-Jeong Park, Mee Kyung Kim, Jinyoung Kim, Ji-Yeon Choi, YoonJu Song and Hyuk-Sang Kwon
Nutrients 2025, 17(9), 1530; https://doi.org/10.3390/nu17091530 - 30 Apr 2025
Viewed by 553
Abstract
Background: Calorie restriction is increasingly recognized as a strategy for glycemic management in type 2 diabetes mellitus (DM) by promoting weight loss and potentially achieving diabetes remission. This study evaluated the feasibility of a 12-week structured calorie-restricted dietary intervention based on healthy [...] Read more.
Background: Calorie restriction is increasingly recognized as a strategy for glycemic management in type 2 diabetes mellitus (DM) by promoting weight loss and potentially achieving diabetes remission. This study evaluated the feasibility of a 12-week structured calorie-restricted dietary intervention based on healthy Korean dietary patterns for adults with early type 2 DM. Methods: Adults aged 18–60 years with a body mass index (BMI) greater than 25 kg/m2 and a short duration of diabetes were recruited. The intervention comprised two phases: a 6-week weight loss phase, targeting a 3% reduction every two weeks, starting with an 800 kcal/day diet and increasing by 200 kcal per phase, with all meals provided via home delivery, followed by a 6-week self-managed weight maintenance period, preceded by a one-week reintroduction phase with meals provided. Results: Among 27 participants, 24 completed the intervention (89% retention). Mean weight reduction at 6 weeks was 6.4 kg (7.6%), primarily achieved during Phase 1 (5.1%). By 12 weeks, the average weight reduction further improved to 7.4 kg (8.7%). Dietary adherence ranged from 80% to 90%, with energy intake closely aligning with the prescribed targets. Non-achievers exhibited a smaller initial reduction (2.5 kg vs. 3.9 kg), with the gap persisting throughout the study. Postprandial glycemic response to a mixed meal (65% carbohydrate) significantly improved from baseline to week 5. Conclusions: This structured dietary intervention demonstrated substantial weight reduction and improved glycemic response in adults with type 2 DM, highlighting its feasibility and effectiveness as a guided strategy for weight management. Full article
(This article belongs to the Special Issue Nutrition for Patients with Diabetes and Clinical Obesity)
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Review

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27 pages, 5646 KiB  
Review
Integrative Roles of Functional Foods, Microbiotics, Nutrigenetics, and Nutrigenomics in Managing Type 2 Diabetes and Obesity
by Hong Nhung Lam, Shih-Ping Lin, Dang Hien Ngan Nguyen, Chiao-Ming Chen, Chien-Tien Su, Te-Chao Fang and Sing-Chung Li
Nutrients 2025, 17(4), 608; https://doi.org/10.3390/nu17040608 - 7 Feb 2025
Cited by 1 | Viewed by 3583
Abstract
Diabetes and obesity are globally prevalent metabolic disorders posing significant public health challenges. The effective management of these conditions requires integrated and personalized strategies. This study conducted a systematic literature review, identifying 335 relevant papers, with 129 core articles selected after screening for [...] Read more.
Diabetes and obesity are globally prevalent metabolic disorders posing significant public health challenges. The effective management of these conditions requires integrated and personalized strategies. This study conducted a systematic literature review, identifying 335 relevant papers, with 129 core articles selected after screening for duplicates and irrelevant studies. The focus of the study is on the synergistic roles of functional foods, microbiotics, and nutrigenomics. Functional foods, including phytochemicals (e.g., polyphenols and dietary fibers), zoochemicals (e.g., essential fatty acids), and bioactive compounds from macrofungi, exhibit significant potential in enhancing insulin sensitivity, regulating lipid metabolism, reducing inflammatory responses, and improving antioxidant capacity. Additionally, the critical role of gut microbiota in metabolic health is highlighted, as its interaction with functional foods facilitates the modulation of metabolic pathways. Nutrigenomics, encompassing nutrigenetics and genomics, reveals how genetic variations (e.g., single-nucleotide polymorphisms (SNPs)) influence dietary responses and gene expression, forming a feedback loop between dietary habits, genetic variations, gut microbiota, and metabolic health. This review integrates functional foods, gut microbiota, and genetic insights to propose comprehensive and sustainable personalized nutrition interventions, offering novel perspectives for preventing and managing type 2 diabetes and obesity. Future clinical studies are warranted to validate the long-term efficacy and safety of these strategies. Full article
(This article belongs to the Special Issue Nutrition for Patients with Diabetes and Clinical Obesity)
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