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Dietary Supplements and Nutraceuticals: Quality and Safety, in Terms of Their Bioaccessiblity and Bioavailability

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 December 2026 | Viewed by 243

Editors


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Guest Editor
Department of Food and Nutrition, Medical University of Lublin, 4a Chodźki Str., 20-093 Lublin, Poland
Interests: dietary supplements; nutraceuticals; bioaccessiblity; bioavailability; nutrients; phytochemicals; toxicity
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Food and Nutrition, Medical University of Lublin, 20-093 Lublin, Poland
Interests: dietary supplements; nutraceuticals; bioaccessiblity; bioavailability; nutrients; phytochemicals; toxicity

Special Issue Information

Dear Colleagues,

Dietary supplements and nutraceuticals currently constitute a significant part of the food market. These products significantly supplement the daily diet with various nutrients, as well as bioactive non-nutrients that positively impact human health. The dietary supplement market is very broad and unregulated in many aspects, especially in the context of their actual health-improving value, effectiveness, and safety.

Important issues related to the effectiveness of dietary supplements concern their bioaccessibility/bioavailability and their actual value in providing nutrients. Safety of use, related to the content of contaminants and their potentially negative impact on health, is also an issue requiring the presentation of the latest research results.

As such, research on this topic to address the biological significance, health relevance, and potential clinical implications of dietary supplements, including both in vitro and animal models, as well as the results of clinical trials, is particularly welcome in this Special Issue.

Prof. Dr. Wojciech Koch
Dr. Justyna Zagórska
Guest Editors

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Keywords

  • dietary supplements
  • nutraceuticals
  • bioaccessiblity
  • bioavailability
  • nutrients
  • phytochemicals
  • toxicity
  • non-nutrients

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Published Papers (1 paper)

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Research

21 pages, 5112 KB  
Article
Comparative Assessment of Commercial Collagen Peptides Following Simulated Gastrointestinal Digestion: Structural Stability, Bioactivity, and Digestibility
by Saeid Chobdar Rahim, Zehra Betül Ahi, Beyza Çay and Fatih Arıcan
Nutrients 2026, 18(14), 2383; https://doi.org/10.3390/nu18142383 - 21 Jul 2026
Abstract
Background/Objectives: Commercial collagen peptide products may differ in their structural characteristics and in vitro biological properties depending on manufacturing processes and hydrolysis conditions. However, comparative studies integrating simulated gastrointestinal digestion with structural, physicochemical, and cell-based analyses remain limited. This study comparatively evaluated [...] Read more.
Background/Objectives: Commercial collagen peptide products may differ in their structural characteristics and in vitro biological properties depending on manufacturing processes and hydrolysis conditions. However, comparative studies integrating simulated gastrointestinal digestion with structural, physicochemical, and cell-based analyses remain limited. This study comparatively evaluated commercially available bovine collagen peptide products marketed in Türkiye before and after simulated gastrointestinal digestion. Methods: Collagen peptide samples were characterized before and after simulated gastrointestinal digestion by determining hydroxyproline content, degree of hydrolysis (DH), molecular weight (MW) distribution, antioxidant activity, and fibroblast responses to investigate digestion-induced structural and biological changes. Results: Significant differences were observed among the evaluated products in hydroxyproline content, degree of hydrolysis, molecular weight distribution, antioxidant activity, and fibroblast responses. Simulated gastrointestinal digestion further hydrolyzed all collagen peptide samples, although the extent of structural modification varied among products. Antioxidant responses also differed following digestion, with some products maintaining relatively stable radical scavenging activity, whereas others exhibited increased or decreased antioxidant responses. Cell viability assays demonstrated that all collagen peptide samples were non-cytotoxic toward L929 fibroblasts under the experimental conditions. Conclusions: The findings indicate that simulated gastrointestinal digestion influences the structural characteristics and in vitro biological responses of commercial collagen peptide products to different extents. The observed differences among products suggest differential in vitro bioactivity associated with their structural characteristics and digestion behavior. Nevertheless, these findings are limited to in vitro observations and require confirmation through peptide characterization, bioavailability studies, animal models, and well-designed clinical investigations before conclusions regarding physiological efficacy or potential health benefits can be drawn. Full article
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