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Effects of Diet and Nutrition on Different Stages of Cancer

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 970

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Guest Editor
CBQF—Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
Interests: nutrition; diet; inflammatory; tumorigenesis; health; anti-inflammatory dietary models; epigenetics
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Special Issue Information

Dear Colleagues,

Diet, nutrition and food biomolecules play critical and intricate roles throughout the cancer process, contributing to its development and progression. Additionally, the maintenance of a balanced nutritional status during cancer treatment is fundamental for success in clinical outcomes. Importantly, cancer survivors and patients seek information about diet not only with the goal of improving overall health, but also to mitigate cancer-related symptoms and minimize the risk of other forms of cancer.

There are, however, several challenges in interpreting diet–cancer relationships related to methodological limitations, the heterogeneity of studies, and the need for the replication of findings. Moreover, some nutritional factors might also impact the risk of recurrence or second primary cancer in cancer patients, highlighting the need for nutritional assessments and support by healthcare professionals in the context of tertiary prevention.

This Special Issue of Nutrients, entitled “Effects of Diet and Nutrition on Different Stages of Cancer”, aims to explore and deepen diet–cancer relationships and welcomes the submission of manuscripts unravelling the impact of diet and dietary components throughout carcinogenesis and cancer disease. Topics of interest include, but are not limited to, those described above. Manuscripts that explore new technologies and approaches, including the use of biomarkers of dietary exposure, the investigation of the molecular structure of nutritional factors and the consideration of dietary patterns, are of particular interest.

Researchers are invited to submit original research articles using any study design, including case studies, cross-sectional studies, implementation or interventional studies, cohort studies, and reviews and meta-analyses. We aim to publish a wide range of papers in this Special Issue and encourage you to submit your research. Additionally, we ask that you please share this announcement with any colleagues you think may be interested.

Dr. Marta Correia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • nutritional factor
  • cancer
  • food intake
  • bioactive molecules

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Published Papers (1 paper)

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Research

16 pages, 4985 KiB  
Article
l-Carnitine and Acetyl-l-Carnitine Induce Metabolism Alteration and Mitophagy-Related Cell Death in Colorectal Cancer Cells
by Isabella Donisi, Anna Balestrieri, Vitale Del Vecchio, Giovanna Bifulco, Maria Luisa Balestrieri, Giuseppe Campanile and Nunzia D’Onofrio
Nutrients 2025, 17(6), 1010; https://doi.org/10.3390/nu17061010 - 13 Mar 2025
Viewed by 871
Abstract
Background/Objectives: Colorectal cancer (CRC) remains one of the most common and deadly malignancies worldwide, driven by metabolic reprogramming and mitochondrial dysfunction, which support tumor growth and progression. Several studies showed that nutrition is a contributing factor in the prevention and management of [...] Read more.
Background/Objectives: Colorectal cancer (CRC) remains one of the most common and deadly malignancies worldwide, driven by metabolic reprogramming and mitochondrial dysfunction, which support tumor growth and progression. Several studies showed that nutrition is a contributing factor in the prevention and management of CRC. In this context, carnitines, amino acid derivatives abundant in food of animal origin, such as meat and milk, are crucial for mitochondrial function. Recently, l-carnitine and acetyl-l-carnitine have received particular attention due to their antioxidant, anti-inflammatory, and antitumor properties. However, to date, there is no conclusive evidence on the effects of l-carnitine and acetyl-l-carnitine in CRC or the underlying molecular mechanism. Methods: In this study, we investigated in HCT 116 and HT-29 CRC cells the effects of l-carnitine and acetyl-l-carnitine on mitochondrial homeostasis by XF HS Seahorse Bioanalyzer and cell death pathways by flow cytometry and western blot assays. Results: Data showed that l-carnitine and acetyl-l-carnitine reduced cell viability (p < 0.001), modulated cellular bioenergetics, and induced oxidative stress (p < 0.001). These phenomena promoted autophagic flux and the mitophagy process via PINK1 and Parkin modulation after 72 h of treatment. Of note, the combined treatment with l-carnitine and acetyl-l-carnitine showed a synergistic effect and enhanced the effect of single carnitines on tumor cell growth and metabolic dysfunction (p < 0.05). Moreover, exposure to l-carnitine and acetyl-l-carnitine promoted CRC cell apoptosis, suggesting a mechanism involving mitophagy-related cell death. These data were associated with increased SIRT4 expression levels (p < 0.01) and the activation of AMPK signaling (p < 0.01). Conclusions: Overall, the results, by supporting the importance of nutritional factors in CRC management, highlight l-carnitine and acetyl-l-carnitine as promising agents to target CRC metabolic vulnerabilities. Full article
(This article belongs to the Special Issue Effects of Diet and Nutrition on Different Stages of Cancer)
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