Special Issue "Toxicity and Ecotoxicity of Nanomaterials"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: closed (27 August 2019).
Interests: cell biology; developmental biology; nanotoxicology; environmental toxicology; microscopy; air pollution; particulate matter; water pollution; pesticides; antimicrobials; sustainable materials; sustainable processes
In the past few decades, an enormous research effort has been made by the scientific community in the characterization of the toxic effects produced by several nanomaterials (NMs) on human and environmental health. In addition, many of these studies were affected by experimental gaps, resulting in little useful data for risk assessment. Among them, NM concentration ranges well beyond the measured or estimated ones and the poor physico-chemical characterizations of the NMs in the exposure media. On the one hand, toxicity and ecotoxicity studies must be implemented by adopting realistic, fully-characterized, exposure systems and more predictive biological models; on the other hand, rooms are available for new studies on the biological mode of action of the still growing number of newly synthesized NMs. These advanced materials are, in fact, designed to improve their efficacy by fine tuning their physico-chemical structurea, such as the manipulation of crystalline structure, introduction of doping elements and/or modification of surface chemistry. Obviously, such new properties may drastically influence the modalities by which a NM interacts with a biological system, as well as the final toxicity, making the exploration of how rendering it safer possible. Both the human toxicology and environmental toxicology fields can take advantage from as such safety-by-material design experimental approach, since benefits are expected in term of exposure to less-toxic materials. Nevertheless, it may significantly improve the basic knowledge of the biological structures and mechanisms involved in response to nano-structures.
In this Special Issue, studies dedicated at improving the robustness of toxicity data in humans and other living organisms are welcome, paying special attention to those performed under realistic exposure conditions, using highly-predictive biological models and endpoints, and/or shedding light on the relationships between NM structure and biological modes of action.
The ambitious goal is to contribute by generating data useful for NM risk assessment and to invest nanotoxicology with a proactive role in the safe-by-design implementation of nanotechnologies.
Dr. Paride Mantecca
Dr. Kaja Kasemets
Manuscript Submission Information
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- human toxicity
- biological mode-of-action