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Nanomaterials
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Polymer Nanomaterials for Tissue Engineering, Wound Dressing and Drug Delivery
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Polymer Nanomaterials for Tissue Engineering, Wound Dressing and Drug Delivery

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 3893

Special Issue Editors

Prof. Dr. Baolin Guo

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Guest Editor
1. Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China
2. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710049, China
Interests: biomaterials; tissue engineering; drug delivery; smart hydrogel; conductive polymers; wound dressing; polymeric hemostat
Special Issues, Collections and Topics in MDPI journals
Dr. Ruonan Dong

E-Mail Website
Assistant Guest Editor
Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China
Interests: conductive polymer; cardiac tissue engineering; muscle tissue engineering; drug and cell delivery; wound dressing

Special Issue Information

Dear Colleagues,

The study of polymer nanomaterials have paved its way in biomedical applications in recent years with the fast development of polymer science and nanotechnology. The development of polymer nanomaterials including nanotubes, nanowires, nanorods, nanocomposites, etc. is of great importance in tissue engineering, wound dressing, and drug delivery. Polymer nanomaterials in tissue engineering can be used to improve cell attachment and adjust cell behaviors. Furthermore, wound dressings based on polymer nanomaterials can promote wound healing with nanoscale effects. One of the most widely used applications of polymer nanomaterials is for drug delivery. Polymer nanomaterials acting as drug carriers can efficiently help drugs through the biological and physical barriers and last the in vivo duration time.

This Special Issue focuses on polymer nanomaterials and their applications in tissue engineering, wound dressing, and drug delivery. It aims to gather the current state-of-the-art works of polymer nanomaterials on their design, process, and applications to give a clear view of the development of this area and new ideas as well as future directions of the polymer nanomaterials.

Prof. Dr. Baolin Guo
Dr. Ruonan Dong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer nanomaterials
  • tissue engineering
  • wound dressing
  • drug delivery
  • nanostructure
  • polymer nanoparticle

 

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Published Papers (2 papers)

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17 pages, 3460 KiB  
Article
Manufacturing of Zinc Oxide Nanoparticle (ZnO NP)-Loaded Polyvinyl Alcohol (PVA) Nanostructured Mats Using Ginger Extract for Tissue Engineering Applications
by Hursima Izgis, Elif Ilhan, Cevriye Kalkandelen, Emrah Celen, Mehmet Mucahit Guncu, Hilal Turkoglu Sasmazel, Oguzhan Gunduz, Denisa Ficai, Anton Ficai and Gabriel Constantinescu
Nanomaterials 2022, 12(17), 3040; https://doi.org/10.3390/nano12173040 - 1 Sep 2022
Cited by 15 | Viewed by 3001
Abstract
In this research, as an alternative to chemical and physical methods, environmentally and cost-effective antimicrobial zinc oxide nanoparticles (ZnO NP) were produced by the green synthesis method. The current study focuses on the production of ZnO NP starting from adequate precursor and Zingiber [...] Read more.
In this research, as an alternative to chemical and physical methods, environmentally and cost-effective antimicrobial zinc oxide nanoparticles (ZnO NP) were produced by the green synthesis method. The current study focuses on the production of ZnO NP starting from adequate precursor and Zingiber officinale aqueous root extracts (ginger). The produced ZnO NP was loaded into electrospun nanofibers at different concentrations for various tissue engineering applications such as wound dressings. The produced ZnO NPs and ZnO NP-loaded nanofibers were examined by Scanning Electron Microscopy (SEM) for morphological assessments and Fourier-transform infrared spectrum (FT-IR) for chemical assessments. The disc diffusion method was used to test the antimicrobial activity of ZnO NP and ZnO NP-loaded nanofibers against three representatives strains, Escherichia coli (Gram-negative bacteria), Staphylococcus aureus (Gram-positive bacteria), and Candida albicans (fungi) microorganisms. The strength and stretching of the produced fibers were assessed using tensile tests. Since water absorption and weight loss behaviors are very important in tissue engineering applications, swelling and degradation analyses were applied to the produced nanofibers. Finally, the MTT test was applied to analyze biocompatibility. According to the findings, ZnO NP-loaded nanofibers were successfully synthesized using a green precipitation approach and can be employed in tissue engineering applications such as wound dressing. Full article
(This article belongs to the Special Issue Polymer Nanomaterials for Tissue Engineering, Wound Dressing and Drug Delivery)
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14 pages, 5012 KiB  
Article
A Combined Cyanine/Carbomer Gel Enhanced Photodynamic Antimicrobial Activity and Wound Healing
by Ming Guan, Guangyu Chu, Jiale Jin, Can Liu, Linxiang Cheng, Yi Guo, Zexing Deng and Yue Wang
Nanomaterials 2022, 12(13), 2173; https://doi.org/10.3390/nano12132173 - 24 Jun 2022
Cited by 15 | Viewed by 2423
Abstract
As a non-invasive and non-specific therapeutic approach, photodynamic therapy (PDT) has been used to treat antibiotic-resistant bacteria with encouraging efficacy. Inspired by light, the photosensitizers can produce excessive reactive oxygen species (ROS) and, thus, effectively destroy or kill bacteria. Cyanine (Cy), a traditional [...] Read more.
As a non-invasive and non-specific therapeutic approach, photodynamic therapy (PDT) has been used to treat antibiotic-resistant bacteria with encouraging efficacy. Inspired by light, the photosensitizers can produce excessive reactive oxygen species (ROS) and, thus, effectively destroy or kill bacteria. Cyanine (Cy), a traditional photosensitizer for PDT, has the advantages of low cytotoxicity and high ROS yield. Yet, the water solubility and photostability for Cy are poor, which substantially limit its antibacterial efficiency and clinical translation. Herein, we combined Cy with carbomer gel (CBMG) to form a photodynamic Cy-CBMG hydrogel. In this system, Cy was evenly dispersed in CBMG, and CBMG significantly improved the water solubility and photostability of Cy via electrostatic interactions. The developed Cy-CBMG gel had less photodegradation under laser irradiation and thus can effectively elevate ROS accumulation in bacteria. The Cy-CBMG compound presented remarkable ROS-induced killing efficacy against methicillin-resistant Staphylococcus aureus (93.0%) and extended-spectrum β-lactamase-producing Escherichia coli (88.7%) in vitro. Moreover, as a potential wound dressing material, the Cy-CBMG hydrogel exhibited excellent biocompatibility and effective antimicrobial ability to promote wound healing in vivo. Overall, this work proposed a practical strategy to synthesize a photosensitizer–excipient compound to enhance the photophysical property and antibacterial efficacy for PDT. Full article
(This article belongs to the Special Issue Polymer Nanomaterials for Tissue Engineering, Wound Dressing and Drug Delivery)
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