Drug Delivery Applications of Nanomaterials for Bone Diseases and Bone Regeneration

Dear Colleagues, 

Many drug classes have been developed in order to treat bone diseases and to promote bone regeneration. Among all, bisphosphonates, antibiotics, monoclonal antibodies, calcitonin and estrogen agonists/antagonists are the most used, although they exhibit several adverse reactions. For this reason, the treatment of bone diseases needs to be improved. In last years, many efforts have been focused on the development of systems able to pass the blood-bone marrow barrier, to release drugs in a controlled manner and to mimic bone structure.

The best results were obtained in the field of nanosystems, that include nanoparticles, scaffolds, hydrogels and cements, composed of different materials (from polymers to ceramics). They exhibit less invasive injections procedures than traditional one and allow improved delivery efficiency. Although many gaps are still present, the extraordinary properties of nanomaterials will open up promising avenues to prevent and treat bone diseases and to promote bone regeneration.

This Special Issue makes a point on the current state-of-the-art, highlighting current progress in nanomaterials for bone targeted drugs.

Dr. Simona Sapino
Guest Editor

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