Special Issue "Drug Delivery Applications of Nanomaterials for Bone Diseases and Bone Regeneration"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 10 December 2020.

Special Issue Editor

Dr. Simona Sapino
Website
Guest Editor
University of Torino, Department of Drug Science and Technology, 10125 Turin, Italy
Interests: formulation of drug delivery systems for systemic or topical administration; development of nano/micro-systems: microemulsions, emulsions, liposomes, lipid nanoparticles; thermosensitive drug delivery systems; inorganic nanoparticles: mesoporous silica nanoparticles, nanotitania; Calcium phosphate coatings; skin delivery of antioxidants; advanced nanosystems for intraocular administrations: nanocomposites, thermosensitive hydrogels, in vitro ocular flow models
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Special Issue Information

Dear Colleagues, 

Many drug classes have been developed in order to treat bone diseases and to promote bone regeneration. Among all, bisphosphonates, antibiotics, monoclonal antibodies, calcitonin and estrogen agonists/antagonists are the most used, although they exhibit several adverse reactions. For this reason, the treatment of bone diseases needs to be improved. In last years, many efforts have been focused on the development of systems able to pass the blood-bone marrow barrier, to release drugs in a controlled manner and to mimic bone structure.

The best results were obtained in the field of nanosystems, that include nanoparticles, scaffolds, hydrogels and cements, composed of different materials (from polymers to ceramics). They exhibit less invasive injections procedures than traditional one and allow improved delivery efficiency. Although many gaps are still present, the extraordinary properties of nanomaterials will open up promising avenues to prevent and treat bone diseases and to promote bone regeneration.

This Special Issue makes a point on the current state-of-the-art, highlighting current progress in nanomaterials for bone targeted drugs.

Dr. Simona Sapino
Guest Editor

Manuscript Submission Information

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Keywords

  • Bone diseases
  • bone regeneration
  • nanosystems
  • drug controlled release

Published Papers (1 paper)

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Review

Open AccessReview
Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
Nanomaterials 2020, 10(5), 875; https://doi.org/10.3390/nano10050875 - 01 May 2020
Abstract
Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. [...] Read more.
Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration. Full article
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