Special Issue "Nanoconstructs Based on Cyclodextrins"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 29 February 2020.

Special Issue Editor

Guest Editor
Prof. Dr. Antonino Mazzaglia Website E-Mail
CNR-ISMN, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences of the University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy
Interests: cyclodextrins; self-assembly; nanodelivery; phototherapeutics; hybrids nanobiomaterials, carbon nanomaterials, nanomedicine, regenerative medicine

Special Issue Information

Dear Colleagues,

Cyclodextrin nanoconstructs (CDnc) have recently aroused the interest of scientific community thanks to a plethora of potential applications. This issue will be focused on nanoconstructs based on native or modified CDs leading to novel polymeric, amphiphilic, metal, and hybrid backbones in material science. These nanoplatforms can have the ability to covalently conjugate active moieties and complex guests through supramolecular interactions or physical entrapment. In this scenario, four research themes are here envisaged:
i) CDnc for drug delivery and nanomedicine (including nanomaterials for pharmaceutics, theranostic, and scaffolds displaying nanodomains for regenerative medicine);
ii) CDnc in food manufacturing;
iii) CDnc in green chemistry and environmental sustainability (together with novel systems built in a nanoscale range for catalysis and conservation of cultural heritage);
iv) Toxicological studies and CDnc/cell interactions;
v) CDnc in renewable energy processes.

Articles will include synthesis of novel functionalized CDs and the formation of nanoassemblies with potential applications in i-v themes or novel and significant applications in i-v of known CDnc. Mini-reviews on the abovementioned research subjects and not recently documented (at least in the last five years) are also fully welcome.

Prof. Antonino Mazzaglia
Guest Editor

Manuscript Submission Information

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Keywords

  • cyclodextrins
  • self-assembly
  • hydrogels
  • drug delivery
  • regenerative medicine
  • theranostic
  • nutraceutics
  • stimuli-responsive materials
  • green chemistry
  • cyclodextrin nanoconstructs/cell interactions

Published Papers (2 papers)

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Research

Open AccessArticle
Design of Engineered Cyclodextrin Derivatives for Spontaneous Coating of Highly Porous Metal-Organic Framework Nanoparticles in Aqueous Media
Nanomaterials 2019, 9(8), 1103; https://doi.org/10.3390/nano9081103 - 01 Aug 2019
Abstract
Nanosized metal-organic frameworks (nanoMOFs) MIL-100(Fe) are highly porous and biodegradable materials that have emerged as promising drug nanocarriers. A challenging issue concerns their surface functionalization in order to evade the immune system and to provide molecular recognition ability, so that they can be [...] Read more.
Nanosized metal-organic frameworks (nanoMOFs) MIL-100(Fe) are highly porous and biodegradable materials that have emerged as promising drug nanocarriers. A challenging issue concerns their surface functionalization in order to evade the immune system and to provide molecular recognition ability, so that they can be used for specific targeting. A convenient method for their coating with tetraethylene glycol, polyethylene glycol, and mannose residues is reported herein. The method consists of the organic solvent-free self-assembly on the nanoMOFs of building blocks based on β-cyclodextrin facially derivatized with the referred functional moieties, and multiple phosphate groups to anchor to the nanoparticles’ surface. The coating of nanoMOFs with cyclodextrin phosphate without further functional groups led to a significant decrease of macrophage uptake, slightly improved by polyethylene glycol or mannose-containing cyclodextrin phosphate coating. More notably, nanoMOFs modified with tetraethylene glycol-containing cyclodextrin phosphate displayed the most efficient “stealth” effect. Mannose-coated nanoMOFs displayed a remarkably enhanced binding affinity towards a specific mannose receptor, such as Concanavalin A, due to the multivalent display of the monosaccharide, as well as reduced macrophage internalization. Coating with tetraethylente glycol of nanoMOFs after loading with doxorubicin is also described. Therefore, phosphorylated cyclodextrins offer a versatile platform to coat nanoMOFs in an organic solvent-free, one step manner, providing them with new biorecognition and/or “stealth” properties. Full article
(This article belongs to the Special Issue Nanoconstructs Based on Cyclodextrins)
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Open AccessArticle
In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease
Nanomaterials 2019, 9(5), 802; https://doi.org/10.3390/nano9050802 - 25 May 2019
Abstract
Niemann-Pick type C disease (NPC) is a fatal, autosomal recessive disorder, which causes excessive accumulation of free cholesterol in endolysosomes, resulting in progressive hepatomegaly and neurodegeneration. Currently, 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) is used at a high dose for the treatment of NPC, risking lung toxicity [...] Read more.
Niemann-Pick type C disease (NPC) is a fatal, autosomal recessive disorder, which causes excessive accumulation of free cholesterol in endolysosomes, resulting in progressive hepatomegaly and neurodegeneration. Currently, 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) is used at a high dose for the treatment of NPC, risking lung toxicity and hearing loss during treatment. One method to reduce the required dose of HP-β-CyD for the treatment of hepatomegaly is to actively deliver β-cyclodextrin (β-CyD) to hepatocytes. Previously, we synthesized lactosyl-β-CyD (Lac-β-CyD) and demonstrated that it lowers cholesterol in NPC model liver cells. In the present study, we studied the efficacy and safety of Lac-β-CyD treatment of hepatomegaly in Npc1−/− mice. After subcutaneous administration, Lac-β-CyD accumulated in the liver and reduced hepatomegaly with greater efficacy than HP-β-CyD. In addition, subcutaneous administration of a very high dose of Lac-β-CyD was less toxic to the lungs than HP-β-CyD. Notably, the accumulation of intracellular free cholesterol in endolysosomes of NPC-like liver cells was significantly lower after administration of Lac-β-CyD than after treatment with HP-β-CyD. In conclusion, these results suggest that Lac-β-CyD is a candidate for the effective treatment of hepatomegaly in NPC. Full article
(This article belongs to the Special Issue Nanoconstructs Based on Cyclodextrins)
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