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Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo

1
Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
2
Research and Application Center for Advanced Technologies (HUNITEK), Hacettepe University, 06100 Ankara, Turkey
3
Institute for Chemical Research, Consejo Superior de Investigaciones Científicas (CSIC), University of Sevilla, Av. Américo Vespucio 49, 41092 Sevilla, Spain
4
Cancer Institute, Department of Basic Oncology, Hacettepe University, 06100 Ankara, Turkey
*
Author to whom correspondence should be addressed.
Academic Editor: Antonino Mazzaglia
Nanomaterials 2021, 11(2), 515; https://doi.org/10.3390/nano11020515
Received: 30 December 2020 / Revised: 14 February 2021 / Accepted: 15 February 2021 / Published: 18 February 2021
(This article belongs to the Special Issue Nanoconstructs Based on Cyclodextrins)
The uniqueness of paclitaxel’s antimitotic action mechanism has fueled research toward its application in more effective and safer cancer treatments. However, the low water solubility, recrystallization, and side effects hinder the clinical success of classic paclitaxel chemotherapy. The aim of this study was to evaluate the in vivo efficacy and biodistribution of paclitaxel encapsulated in injectable amphiphilic cyclodextrin nanoparticles of different surface charges. It was found that paclitaxel-loaded amphiphilic cyclodextrin nanoparticles showed an antitumoral effect earlier than the drug solution. Moreover, the blank nanoparticles reduced the tumor growth with a similar trend to the paclitaxel solution. At 24 h, the nanoparticles had not accumulated in the heart and lungs according to the biodistribution assessed by in vivo imaging. Therefore, our results indicated that the amphiphilic cyclodextrin nanoparticles are potentially devoid of cardiac toxicity, which limits the clinical use and commercialization of certain polymeric nanoparticles. In conclusion, the amphiphilic cyclodextrin nanoparticles with different surface charge increased the efficiency of paclitaxel in vitro and in vivo. Cyclodextrin nanoparticles could be a good candidate vehicle for intravenous paclitaxel delivery. View Full-Text
Keywords: tumor targeting; cyclodextrin; nanoparticle; paclitaxel; biodistribution; breast tumor induced animal model tumor targeting; cyclodextrin; nanoparticle; paclitaxel; biodistribution; breast tumor induced animal model
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MDPI and ACS Style

Varan, G.; Varan, C.; Öztürk, S.C.; Benito, J.M.; Esendağlı, G.; Bilensoy, E. Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo. Nanomaterials 2021, 11, 515. https://doi.org/10.3390/nano11020515

AMA Style

Varan G, Varan C, Öztürk SC, Benito JM, Esendağlı G, Bilensoy E. Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo. Nanomaterials. 2021; 11(2):515. https://doi.org/10.3390/nano11020515

Chicago/Turabian Style

Varan, Gamze; Varan, Cem; Öztürk, Süleyman C.; Benito, Juan M.; Esendağlı, Güneş; Bilensoy, Erem. 2021. "Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo" Nanomaterials 11, no. 2: 515. https://doi.org/10.3390/nano11020515

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