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Article

Cyclodextrin Cationic Polymer-Based Nanoassemblies to Manage Inflammation by Intra-Articular Delivery Strategies

1
CNR-ISMN, Istituto per lo Studio dei Materiali Nanostrutturati, V. le F. Stagno d’Alcontres 31, 98166 Messina, Italy
2
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, V. le F. Stagno d’Alcontres 31, 98166 Messina, Italy
3
CycloLab, Illatos út 7, H-1097 Budapest, Hungary
4
Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr. Bldg 37, D-66421 Homburg/Saar, Germany
5
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+DFarma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15872 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(9), 1712; https://doi.org/10.3390/nano10091712
Received: 20 July 2020 / Revised: 26 August 2020 / Accepted: 27 August 2020 / Published: 29 August 2020
(This article belongs to the Special Issue Nanoconstructs Based on Cyclodextrins)
Injectable nanobioplatforms capable of locally fighting the inflammation in osteoarticular diseases, by reducing the number of administrations and prolonging the therapeutic effect is highly challenging. β-Cyclodextrin cationic polymers are promising cartilage-penetrating candidates by intra-articular injection due to the high biocompatibility and ability to entrap multiple therapeutic and diagnostic agents, thus monitoring and mitigating inflammation. In this study, nanoassemblies based on poly-β-amino-cyclodextrin (PolyCD) loaded with the non-steroidal anti-inflammatory drug diclofenac (DCF) and linked by supramolecular interactions with a fluorescent probe (adamantanyl-Rhodamine conjugate, Ada-Rhod) were developed to manage inflammation in osteoarticular diseases. [email protected]/DCF supramolecular nanoassemblies were characterized by complementary spectroscopic techniques including UV-Vis, steady-state and time-resolved fluorescence, DLS and ζ-potential measurement. Stability and DCF release kinetics were investigated in medium mimicking the physiological conditions to ensure control over time and efficacy. Biological experiments evidenced the efficient cellular internalization of [email protected]/DCF (within two hours) without significant cytotoxicity in primary human bone marrow-derived mesenchymal stromal cells (hMSCs). Finally, [email protected]/DCF significantly suppressed IL-1β production in hMSCs, revealing the anti-inflammatory properties of these nanoassemblies. With these premises, this study might open novel routes to exploit original CD-based nanobiomaterials for the treatment of osteoarticular diseases. View Full-Text
Keywords: polymeric cyclodextrins; IL-1β; human marrow-derived mesenchymal stromal cells; rhodamine polymeric cyclodextrins; IL-1β; human marrow-derived mesenchymal stromal cells; rhodamine
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MDPI and ACS Style

Cordaro, A.; Zagami, R.; Malanga, M.; Venkatesan, J.K.; Alvarez-Lorenzo, C.; Cucchiarini, M.; Piperno, A.; Mazzaglia, A. Cyclodextrin Cationic Polymer-Based Nanoassemblies to Manage Inflammation by Intra-Articular Delivery Strategies. Nanomaterials 2020, 10, 1712. https://doi.org/10.3390/nano10091712

AMA Style

Cordaro A, Zagami R, Malanga M, Venkatesan JK, Alvarez-Lorenzo C, Cucchiarini M, Piperno A, Mazzaglia A. Cyclodextrin Cationic Polymer-Based Nanoassemblies to Manage Inflammation by Intra-Articular Delivery Strategies. Nanomaterials. 2020; 10(9):1712. https://doi.org/10.3390/nano10091712

Chicago/Turabian Style

Cordaro, Annalaura, Roberto Zagami, Milo Malanga, Jagadeesh K. Venkatesan, Carmen Alvarez-Lorenzo, Magali Cucchiarini, Anna Piperno, and Antonino Mazzaglia. 2020. "Cyclodextrin Cationic Polymer-Based Nanoassemblies to Manage Inflammation by Intra-Articular Delivery Strategies" Nanomaterials 10, no. 9: 1712. https://doi.org/10.3390/nano10091712

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