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Prof. Dr. Tânia Santos de Almeida
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Guest Editor

CBIOS-Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749–024 Lisboa, Portugal
Interests: ionic-liquid–nanoparticle hybrid systems; delivery systems; functional excipients in drug delivery

Prof. Dr. Catarina Pereira-Leite
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Guest Editor

CBIOS-Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749–024 Lisboa, Portugal
Interests: nanomedicine; drug delivery; lipid nanoparticles; vesicular delivery systems

Special Issue Information

Dear Colleagues,

We kindly invite you to submit your contribution to the Special Issue entitled “Delivery Systems Based on Innovative Nanomaterials”. This issue will include several topics concerning innovative nanomaterials towards diagnosis, therapeutics, cosmetics, chemical and biological sensing, and regenerative medicine, amongst other relevant topics.

The main goal of this issue is to showcase innovative ways of using nanomaterials and nano-based formulations in the development of delivery systems. Up-to-date original research and reviews on the ground-breaking applications of nanomaterials will be appreciated.

Your contributions are welcome, and we look forward to receiving your interesting work.

Prof. Dr. Tânia Santos de Almeida
Prof. Dr. Catarina Pereira-Leite
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Nanoparticles
Delivery systems
Targeted delivery
Innovative systems
Hybrid nanosystems

Published Papers (2 papers)

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Research

Open AccessArticle

Docetaxel-Loaded Poly(3HB-co-4HB) Biodegradable Nanoparticles: Impact of Copolymer Composition

and

Mohamed Isa Abdul Majid

Nanomaterials 2020, 10(11), 2123; https://doi.org/10.3390/nano10112123 - 26 Oct 2020

Abstract

Polyhydroxyalkanoate (PHA) copolymers show a relatively higher in vivo degradation rate compared to other PHAs, thus, they receive a great deal of attention for a wide range of medical applications. Nanoparticles (NPs) loaded with poorly water-soluble anticancer drug docetaxel (DCX) were produced using poly(3-hydroxybutyrate-co-4-hydroxybutyrate), P(3HB-co-4HB), copolymers biosynthesised from Cupriavidus malaysiensis USMAA1020 isolated from the Malaysian environment. Three copolymers with different molar proportions of 4-hydroxybutirate (4HB) were used: 16% (PHB16), 30% (PHB30) and 70% (PHB70) 4HB-containing P(3HB-co-4HB). Blank and DCX-loaded nanoparticles were then characterized for their size and size distribution, surface charge, encapsulation efficiency and drug release. Preformulation studies showed that an optimised formulation could be achieved through the emulsification/solvent evaporation method using PHB70 with the addition of 1.0% PVA, as stabilizer and 0.03% VitE-TPGS, as surfactant. DCX-loaded PHB70 nanoparticles (DCX-PHB70) gave the desired particle size distribution in terms of average particle size around 150 nm and narrow particle size distribution (polydispersity index (PDI) below 0.100). The encapsulation efficiency result showed that at 30% w/w drug-to-polymer ratio: DCX- PHB16 NPs were able to encapsulate up to 42% of DCX; DCX-PHB30 NPs encapsulated up to 46% of DCX and DCX-PHB70 NPs encapsulated up to 50% of DCX within the nanoparticle system. Approximately 60% of DCX was released from the DCX-PHB70 NPs within 7 days for 5%, 10% and 20% of drug-to-polymer ratio while for the 30% and 40% drug-to-polymer ratios, an almost complete drug release (98%) after 7 days of incubation was observed. Full article

(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)

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Open AccessArticle

Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties

Elena Giuliano

Donatella Paolino

Maria Chiara Cristiano

Massimo Fresta

and

Donato Cosco

Nanomaterials 2020, 10(6), 1069; https://doi.org/10.3390/nano10061069 - 31 May 2020

Cited by 2

Abstract

Rutin is a flavone glycoside contained in many plants, and exhibits antioxidant, anti-inflammatory, anticancer, and wound-healing properties. The main disadvantage related to the use of this molecule for pharmaceutical application is its poor bioavailability, due to its low solubility in aqueous media. Poloxamer 407-hydrogels show interesting thermo-sensitive properties that make them attractive candidates as pharmaceutical formulations. The hydrophobic domains in the chemical structure of the copolymer, a polymer made up of two or more monomer species, are useful for retaining poorly water-soluble compounds. In this investigation various poloxamer 407-based hydrogels containing rutin were developed and characterized as a function of the drug concentration. In detail, the Turbiscan stability index, the micro- and dynamic rheological profiles and in vitro drug release were investigated and discussed. Rutin (either as a free powder or solubilized in ethanol) did not modify the stability or the rheological properties of these poloxamer 407-based hydrogels. The drug leakage was constant and prolonged for up to 72 h. The formulations described are expected to represent suitable systems for the in situ application of the bioactive as a consequence of their peculiar versatility. Full article

(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)

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