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Nanomaterials
Special Issues
Delivery Systems Based on Innovative Nanomaterials
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Delivery Systems Based on Innovative Nanomaterials

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 20892

Special Issue Editors

Prof. Dr. Tânia Santos de Almeida

E-Mail Website
Guest Editor
CBIOS-Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749–024 Lisboa, Portugal
Interests: ionic-liquid–nanoparticle hybrid systems; delivery systems; functional excipients in drug delivery
Dr. Catarina Pereira-Leite

E-Mail Website
Guest Editor
CBIOS - Research Center for Biosciences and Health Technologies, Lusófona University, Lisbon, Portugal
Interests: nanomedicine and nanocosmetics; drug delivery; lipid-based nanosystems; membrane model systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We kindly invite you to submit your contribution to the Special Issue entitled “Delivery Systems Based on Innovative Nanomaterials”. This issue will include several topics concerning innovative nanomaterials towards diagnosis, therapeutics, cosmetics, chemical and biological sensing, and regenerative medicine, amongst other relevant topics.

The main goal of this issue is to showcase innovative ways of using nanomaterials and nano-based formulations in the development of delivery systems. Up-to-date original research and reviews on the ground-breaking applications of nanomaterials will be appreciated.

Your contributions are welcome, and we look forward to receiving your interesting work.

Prof. Dr. Tânia Santos de Almeida
Prof. Dr. Catarina Pereira-Leite
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanoparticles
  • Delivery systems
  • Targeted delivery
  • Innovative systems
  • Hybrid nanosystems

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Published Papers (5 papers)

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Editorial

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2 pages, 190 KiB  
Editorial
Delivery Systems Based on Innovative Nanomaterials
by Tânia Santos de Almeida and Catarina Pereira-Leite
Nanomaterials 2022, 12(8), 1296; https://doi.org/10.3390/nano12081296 - 11 Apr 2022
Cited by 2 | Viewed by 1419
Abstract
There has been an increasing interest in using nanomaterials to develop innovative delivery systems [...] Full article
(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)

Research

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16 pages, 1755 KiB  
Article
TransfersomILs: From Ionic Liquids to a New Class of Nanovesicular Systems
by Ana Júlio, João Guilherme Costa, Catarina Pereira-Leite and Tânia Santos de Almeida
Nanomaterials 2022, 12(1), 7; https://doi.org/10.3390/nano12010007 - 21 Dec 2021
Cited by 11 | Viewed by 3456
Abstract
Ionic liquids (ILs) have increasingly been studied as key materials to upgrade the performance of many pharmaceutical formulations. In controlled delivery systems, ILs have improved multiple physicochemical properties, showing the relevance of continuing to study their incorporation into these formulations. Transfersomes are biocompatible [...] Read more.
Ionic liquids (ILs) have increasingly been studied as key materials to upgrade the performance of many pharmaceutical formulations. In controlled delivery systems, ILs have improved multiple physicochemical properties, showing the relevance of continuing to study their incorporation into these formulations. Transfersomes are biocompatible nanovesicular systems, quite useful in controlled delivery. They have promising characteristics, such as elasticity and deformability, making them suitable for cutaneous delivery. Nonetheless, their overall properties and performance may still be improved. Herein, new TransfersomILs systems to load rutin were developed and the physicochemical properties of the formulations were assessed. These systems were prepared based on an optimized formulation obtained from a Box–Behnken factorial design (BBD). The impact of imidazole-based ILs, cholinium-based ILs, and their combinations on the cell viability of HaCaT cells and on the solubility of rutin was initially assessed. The newly developed TransfersomILs containing rutin presented a smaller size and, in general, a higher association efficiency, loading capacity, and total amount of drug release compared to the formulation without IL. The ILs also promoted the colloidal stability of the vesicles, upgrading storage stability. Thus, ILs were a bridge to develop new TransfersomILs systems with an overall improved performance. Full article
(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)
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13 pages, 2641 KiB  
Article
Docetaxel-Loaded Poly(3HB-co-4HB) Biodegradable Nanoparticles: Impact of Copolymer Composition
by A.F. Faisalina, Fabio Sonvico, Paolo Colombo, A.A. Amirul, H.A. Wahab and Mohamed Isa Abdul Majid
Nanomaterials 2020, 10(11), 2123; https://doi.org/10.3390/nano10112123 - 26 Oct 2020
Cited by 22 | Viewed by 3557
Abstract
Polyhydroxyalkanoate (PHA) copolymers show a relatively higher in vivo degradation rate compared to other PHAs, thus, they receive a great deal of attention for a wide range of medical applications. Nanoparticles (NPs) loaded with poorly water-soluble anticancer drug docetaxel (DCX) were produced using [...] Read more.
Polyhydroxyalkanoate (PHA) copolymers show a relatively higher in vivo degradation rate compared to other PHAs, thus, they receive a great deal of attention for a wide range of medical applications. Nanoparticles (NPs) loaded with poorly water-soluble anticancer drug docetaxel (DCX) were produced using poly(3-hydroxybutyrate-co-4-hydroxybutyrate), P(3HB-co-4HB), copolymers biosynthesised from Cupriavidus malaysiensis USMAA1020 isolated from the Malaysian environment. Three copolymers with different molar proportions of 4-hydroxybutirate (4HB) were used: 16% (PHB16), 30% (PHB30) and 70% (PHB70) 4HB-containing P(3HB-co-4HB). Blank and DCX-loaded nanoparticles were then characterized for their size and size distribution, surface charge, encapsulation efficiency and drug release. Preformulation studies showed that an optimised formulation could be achieved through the emulsification/solvent evaporation method using PHB70 with the addition of 1.0% PVA, as stabilizer and 0.03% VitE-TPGS, as surfactant. DCX-loaded PHB70 nanoparticles (DCX-PHB70) gave the desired particle size distribution in terms of average particle size around 150 nm and narrow particle size distribution (polydispersity index (PDI) below 0.100). The encapsulation efficiency result showed that at 30% w/w drug-to-polymer ratio: DCX- PHB16 NPs were able to encapsulate up to 42% of DCX; DCX-PHB30 NPs encapsulated up to 46% of DCX and DCX-PHB70 NPs encapsulated up to 50% of DCX within the nanoparticle system. Approximately 60% of DCX was released from the DCX-PHB70 NPs within 7 days for 5%, 10% and 20% of drug-to-polymer ratio while for the 30% and 40% drug-to-polymer ratios, an almost complete drug release (98%) after 7 days of incubation was observed. Full article
(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)
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21 pages, 3955 KiB  
Article
Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties
by Elena Giuliano, Donatella Paolino, Maria Chiara Cristiano, Massimo Fresta and Donato Cosco
Nanomaterials 2020, 10(6), 1069; https://doi.org/10.3390/nano10061069 - 31 May 2020
Cited by 46 | Viewed by 6978
Abstract
Rutin is a flavone glycoside contained in many plants, and exhibits antioxidant, anti-inflammatory, anticancer, and wound-healing properties. The main disadvantage related to the use of this molecule for pharmaceutical application is its poor bioavailability, due to its low solubility in aqueous media. Poloxamer [...] Read more.
Rutin is a flavone glycoside contained in many plants, and exhibits antioxidant, anti-inflammatory, anticancer, and wound-healing properties. The main disadvantage related to the use of this molecule for pharmaceutical application is its poor bioavailability, due to its low solubility in aqueous media. Poloxamer 407-hydrogels show interesting thermo-sensitive properties that make them attractive candidates as pharmaceutical formulations. The hydrophobic domains in the chemical structure of the copolymer, a polymer made up of two or more monomer species, are useful for retaining poorly water-soluble compounds. In this investigation various poloxamer 407-based hydrogels containing rutin were developed and characterized as a function of the drug concentration. In detail, the Turbiscan stability index, the micro- and dynamic rheological profiles and in vitro drug release were investigated and discussed. Rutin (either as a free powder or solubilized in ethanol) did not modify the stability or the rheological properties of these poloxamer 407-based hydrogels. The drug leakage was constant and prolonged for up to 72 h. The formulations described are expected to represent suitable systems for the in situ application of the bioactive as a consequence of their peculiar versatility. Full article
(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)
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Review

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17 pages, 1123 KiB  
Review
Nanodelivery Strategies for Skin Diseases with Barrier Impairment: Focusing on Ceramides and Glucocorticoids
by Cíntia Almeida, Patrícia Filipe, Catarina Rosado and Catarina Pereira-Leite
Nanomaterials 2022, 12(2), 275; https://doi.org/10.3390/nano12020275 - 15 Jan 2022
Cited by 12 | Viewed by 4485
Abstract
The human epidermis has a characteristic lipidic composition in the stratum corneum, where ceramides play a crucial role in the skin barrier homeostasis and in water-holding capacity. Several skin diseases, such as atopic dermatitis and psoriasis, exhibit a dysfunction in the lipid barrier [...] Read more.
The human epidermis has a characteristic lipidic composition in the stratum corneum, where ceramides play a crucial role in the skin barrier homeostasis and in water-holding capacity. Several skin diseases, such as atopic dermatitis and psoriasis, exhibit a dysfunction in the lipid barrier with altered ceramide levels and increased loss of transepidermal water. Glucocorticoids are normally employed in the therapeutical management of these pathologies. However, they have shown a poor safety profile and reduced treatment efficiency. The main objective of this review is to, within the framework of the limitations of the currently available therapeutical approaches, establish the relevance of nanocarriers as a safe and efficient delivery strategy for glucocorticoids and ceramides in the topical treatment of skin disorders with barrier impairment. Full article
(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)
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