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Special Issue "Delivery Systems Based on Innovative Nanomaterials"

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A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 11009

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Special Issue Editors

Prof. Dr. Tânia Santos de Almeida

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Guest Editor

CBIOS-Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749–024 Lisboa, Portugal
Interests: ionic-liquid–nanoparticle hybrid systems; delivery systems; functional excipients in drug delivery

Prof. Dr. Catarina Pereira-Leite

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Guest Editor

CBIOS-Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749–024 Lisboa, Portugal
Interests: nanomedicine; drug delivery; lipid nanoparticles; vesicular delivery systems

Special Issue Information

Dear Colleagues,

We kindly invite you to submit your contribution to the Special Issue entitled “Delivery Systems Based on Innovative Nanomaterials”. This issue will include several topics concerning innovative nanomaterials towards diagnosis, therapeutics, cosmetics, chemical and biological sensing, and regenerative medicine, amongst other relevant topics.

The main goal of this issue is to showcase innovative ways of using nanomaterials and nano-based formulations in the development of delivery systems. Up-to-date original research and reviews on the ground-breaking applications of nanomaterials will be appreciated.

Your contributions are welcome, and we look forward to receiving your interesting work.

Prof. Dr. Tânia Santos de Almeida
Prof. Dr. Catarina Pereira-Leite
Guest Editors

Manuscript Submission Information

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Keywords

Nanoparticles
Delivery systems
Targeted delivery
Innovative systems
Hybrid nanosystems

Published Papers (5 papers)

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Editorial

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Open AccessEditorial

Delivery Systems Based on Innovative Nanomaterials

Tânia Santos de Almeida

and

Catarina Pereira-Leite

Nanomaterials 2022, 12(8), 1296; https://doi.org/10.3390/nano12081296 - 11 Apr 2022

Cited by 1 | Viewed by 694

Abstract

There has been an increasing interest in using nanomaterials to develop innovative delivery systems [...] Full article

(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)

Research

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Open AccessFeature PaperArticle

TransfersomILs: From Ionic Liquids to a New Class of Nanovesicular Systems

Ana Júlio

João Guilherme Costa

Catarina Pereira-Leite

and

Tânia Santos de Almeida

Nanomaterials 2022, 12(1), 7; https://doi.org/10.3390/nano12010007 - 21 Dec 2021

Cited by 4 | Viewed by 1967

Abstract

Ionic liquids (ILs) have increasingly been studied as key materials to upgrade the performance of many pharmaceutical formulations. In controlled delivery systems, ILs have improved multiple physicochemical properties, showing the relevance of continuing to study their incorporation into these formulations. Transfersomes are biocompatible nanovesicular systems, quite useful in controlled delivery. They have promising characteristics, such as elasticity and deformability, making them suitable for cutaneous delivery. Nonetheless, their overall properties and performance may still be improved. Herein, new TransfersomILs systems to load rutin were developed and the physicochemical properties of the formulations were assessed. These systems were prepared based on an optimized formulation obtained from a Box–Behnken factorial design (BBD). The impact of imidazole-based ILs, cholinium-based ILs, and their combinations on the cell viability of HaCaT cells and on the solubility of rutin was initially assessed. The newly developed TransfersomILs containing rutin presented a smaller size and, in general, a higher association efficiency, loading capacity, and total amount of drug release compared to the formulation without IL. The ILs also promoted the colloidal stability of the vesicles, upgrading storage stability. Thus, ILs were a bridge to develop new TransfersomILs systems with an overall improved performance. Full article

(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)

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Open AccessArticle

Docetaxel-Loaded Poly(3HB-co-4HB) Biodegradable Nanoparticles: Impact of Copolymer Composition

and

Mohamed Isa Abdul Majid

Nanomaterials 2020, 10(11), 2123; https://doi.org/10.3390/nano10112123 - 26 Oct 2020

Cited by 11 | Viewed by 2124

Abstract

Polyhydroxyalkanoate (PHA) copolymers show a relatively higher in vivo degradation rate compared to other PHAs, thus, they receive a great deal of attention for a wide range of medical applications. Nanoparticles (NPs) loaded with poorly water-soluble anticancer drug docetaxel (DCX) were produced using poly(3-hydroxybutyrate-co-4-hydroxybutyrate), P(3HB-co-4HB), copolymers biosynthesised from Cupriavidus malaysiensis USMAA1020 isolated from the Malaysian environment. Three copolymers with different molar proportions of 4-hydroxybutirate (4HB) were used: 16% (PHB16), 30% (PHB30) and 70% (PHB70) 4HB-containing P(3HB-co-4HB). Blank and DCX-loaded nanoparticles were then characterized for their size and size distribution, surface charge, encapsulation efficiency and drug release. Preformulation studies showed that an optimised formulation could be achieved through the emulsification/solvent evaporation method using PHB70 with the addition of 1.0% PVA, as stabilizer and 0.03% VitE-TPGS, as surfactant. DCX-loaded PHB70 nanoparticles (DCX-PHB70) gave the desired particle size distribution in terms of average particle size around 150 nm and narrow particle size distribution (polydispersity index (PDI) below 0.100). The encapsulation efficiency result showed that at 30% w/w drug-to-polymer ratio: DCX- PHB16 NPs were able to encapsulate up to 42% of DCX; DCX-PHB30 NPs encapsulated up to 46% of DCX and DCX-PHB70 NPs encapsulated up to 50% of DCX within the nanoparticle system. Approximately 60% of DCX was released from the DCX-PHB70 NPs within 7 days for 5%, 10% and 20% of drug-to-polymer ratio while for the 30% and 40% drug-to-polymer ratios, an almost complete drug release (98%) after 7 days of incubation was observed. Full article

(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)

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Open AccessArticle

Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties

Elena Giuliano

Donatella Paolino

Maria Chiara Cristiano

Massimo Fresta

and

Donato Cosco

Nanomaterials 2020, 10(6), 1069; https://doi.org/10.3390/nano10061069 - 31 May 2020

Cited by 28 | Viewed by 3990

Abstract

Rutin is a flavone glycoside contained in many plants, and exhibits antioxidant, anti-inflammatory, anticancer, and wound-healing properties. The main disadvantage related to the use of this molecule for pharmaceutical application is its poor bioavailability, due to its low solubility in aqueous media. Poloxamer 407-hydrogels show interesting thermo-sensitive properties that make them attractive candidates as pharmaceutical formulations. The hydrophobic domains in the chemical structure of the copolymer, a polymer made up of two or more monomer species, are useful for retaining poorly water-soluble compounds. In this investigation various poloxamer 407-based hydrogels containing rutin were developed and characterized as a function of the drug concentration. In detail, the Turbiscan stability index, the micro- and dynamic rheological profiles and in vitro drug release were investigated and discussed. Rutin (either as a free powder or solubilized in ethanol) did not modify the stability or the rheological properties of these poloxamer 407-based hydrogels. The drug leakage was constant and prolonged for up to 72 h. The formulations described are expected to represent suitable systems for the in situ application of the bioactive as a consequence of their peculiar versatility. Full article

(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)

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Review

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Open AccessEditor’s ChoiceReview

Nanodelivery Strategies for Skin Diseases with Barrier Impairment: Focusing on Ceramides and Glucocorticoids

Cíntia Almeida

Patrícia Filipe

Catarina Rosado

and

Catarina Pereira-Leite

Nanomaterials 2022, 12(2), 275; https://doi.org/10.3390/nano12020275 - 15 Jan 2022

Cited by 3 | Viewed by 1621

Abstract

The human epidermis has a characteristic lipidic composition in the stratum corneum, where ceramides play a crucial role in the skin barrier homeostasis and in water-holding capacity. Several skin diseases, such as atopic dermatitis and psoriasis, exhibit a dysfunction in the lipid barrier with altered ceramide levels and increased loss of transepidermal water. Glucocorticoids are normally employed in the therapeutical management of these pathologies. However, they have shown a poor safety profile and reduced treatment efficiency. The main objective of this review is to, within the framework of the limitations of the currently available therapeutical approaches, establish the relevance of nanocarriers as a safe and efficient delivery strategy for glucocorticoids and ceramides in the topical treatment of skin disorders with barrier impairment. Full article

(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)

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