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Open AccessArticle

Docetaxel-Loaded Poly(3HB-co-4HB) Biodegradable Nanoparticles: Impact of Copolymer Composition

1
Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institute of Biotechnology Malaysia (NIBM), Ministry of Science, Technology and Innovation (MOSTI), Penang 11800, Malaysia
2
Food and Drug Department, University of Parma, 43124 (PR) Parma, Italy
3
School of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(11), 2123; https://doi.org/10.3390/nano10112123
Received: 29 September 2020 / Revised: 17 October 2020 / Accepted: 22 October 2020 / Published: 26 October 2020
(This article belongs to the Special Issue Delivery Systems Based on Innovative Nanomaterials)
Polyhydroxyalkanoate (PHA) copolymers show a relatively higher in vivo degradation rate compared to other PHAs, thus, they receive a great deal of attention for a wide range of medical applications. Nanoparticles (NPs) loaded with poorly water-soluble anticancer drug docetaxel (DCX) were produced using poly(3-hydroxybutyrate-co-4-hydroxybutyrate), P(3HB-co-4HB), copolymers biosynthesised from Cupriavidus malaysiensis USMAA1020 isolated from the Malaysian environment. Three copolymers with different molar proportions of 4-hydroxybutirate (4HB) were used: 16% (PHB16), 30% (PHB30) and 70% (PHB70) 4HB-containing P(3HB-co-4HB). Blank and DCX-loaded nanoparticles were then characterized for their size and size distribution, surface charge, encapsulation efficiency and drug release. Preformulation studies showed that an optimised formulation could be achieved through the emulsification/solvent evaporation method using PHB70 with the addition of 1.0% PVA, as stabilizer and 0.03% VitE-TPGS, as surfactant. DCX-loaded PHB70 nanoparticles (DCX-PHB70) gave the desired particle size distribution in terms of average particle size around 150 nm and narrow particle size distribution (polydispersity index (PDI) below 0.100). The encapsulation efficiency result showed that at 30% w/w drug-to-polymer ratio: DCX- PHB16 NPs were able to encapsulate up to 42% of DCX; DCX-PHB30 NPs encapsulated up to 46% of DCX and DCX-PHB70 NPs encapsulated up to 50% of DCX within the nanoparticle system. Approximately 60% of DCX was released from the DCX-PHB70 NPs within 7 days for 5%, 10% and 20% of drug-to-polymer ratio while for the 30% and 40% drug-to-polymer ratios, an almost complete drug release (98%) after 7 days of incubation was observed. View Full-Text
Keywords: biodegradable polymers; nanoparticles; cancer chemotherapy; controlled release; drug delivery systems biodegradable polymers; nanoparticles; cancer chemotherapy; controlled release; drug delivery systems
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MDPI and ACS Style

Faisalina, A.F.; Sonvico, F.; Colombo, P.; Amirul, A.A.; Wahab, H.A.; Majid, M.I.A. Docetaxel-Loaded Poly(3HB-co-4HB) Biodegradable Nanoparticles: Impact of Copolymer Composition. Nanomaterials 2020, 10, 2123. https://doi.org/10.3390/nano10112123

AMA Style

Faisalina AF, Sonvico F, Colombo P, Amirul AA, Wahab HA, Majid MIA. Docetaxel-Loaded Poly(3HB-co-4HB) Biodegradable Nanoparticles: Impact of Copolymer Composition. Nanomaterials. 2020; 10(11):2123. https://doi.org/10.3390/nano10112123

Chicago/Turabian Style

Faisalina, A.F.; Sonvico, Fabio; Colombo, Paolo; Amirul, A.A.; Wahab, H.A.; Majid, Mohamed I.A. 2020. "Docetaxel-Loaded Poly(3HB-co-4HB) Biodegradable Nanoparticles: Impact of Copolymer Composition" Nanomaterials 10, no. 11: 2123. https://doi.org/10.3390/nano10112123

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