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Pharmaceutics
Special Issues
Emerging Trends in Skin Delivery Systems
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Emerging Trends in Skin Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 2687

Special Issue Editors

Dr. Catarina Pereira-Leite

E-Mail Website
Guest Editor
CBIOS - Research Center for Biosciences and Health Technologies, Lusófona University, Lisbon, Portugal
Interests: nanomedicine and nanocosmetics; drug delivery; lipid-based nanosystems; membrane model systems
Special Issues, Collections and Topics in MDPI journals
Dr. Catarina Rosado

E-Mail Website
Guest Editor
CBIOS - Research Center for Biosciences and Health Technologies, Lusófona University, Lisbon, Portugal
Interests: transdermal drug delivery; efficacy and safety testing; biomaterials as topical, transdermal, and cosmetic ingredients; nutrition and skin health
Special Issues, Collections and Topics in MDPI journals
Dr. Ana Júlio

E-Mail Website
Guest Editor
CBIOS—Research Center for Biosciences and Health Technologies, Lusófona University, Lisbon, Portugal
Interests: controlled and/or sustained drug delivery; topical delivery; skin application; hybrid nanosystems; ionic liquids; nanosystems; cosmetics

Special Issue Information

Dear Colleagues,

We kindly invite you to submit your contribution to this Special Issue entitled “Emerging Trends in Skin Delivery Systems”.

This Special Issue focuses on emerging trends for designing and characterizing delivery systems for skin applications. Up-to-date original research and ground-breaking reviews are sought, covering a wide range of topics ranging from innovative excipients to nanotechnology-based formulations. This Special Issue will encompass delivery systems developed for drugs, biopharmaceuticals, and bioactive compounds. Studies exploring advanced skin models to test the safety and efficacy of delivery systems are also welcome.

This Special Issue will be of special interest to those exploring advanced delivery systems designed to overcome the skin barrier.

Your contributions are welcome, and we look forward to receiving your interesting manuscripts.

Dr. Catarina Pereira-Leite
Dr. Catarina Rosado
Dr. Ana Júlio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • delivery systems
  • topical and transdermal delivery
  • innovative excipients
  • nanoparticles
  • skin models

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Published Papers (2 papers)

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Research

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12 pages, 827 KiB  
Article
Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration
by Chiara G. M. Gennari, Antonella Casiraghi, Francesca Selmin and Francesco Cilurzo
Pharmaceutics 2025, 17(1), 88; https://doi.org/10.3390/pharmaceutics17010088 - 11 Jan 2025
Viewed by 1046
Abstract
Background/Objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit® E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.e., tributylcitrate, glycerine, triacetin and PEG 400). Methods: The physicochemical [...] Read more.
Background/Objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit® E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.e., tributylcitrate, glycerine, triacetin and PEG 400). Methods: The physicochemical and mechanical properties of the FFS and dried films were evaluated in terms of formation time, stickiness, Tg, tensile strength, break elongation and Young’s modulus. The in vitro skin permeation studies were conducted on formulations containing caffeine and testosterone. Results: The FFS, consisting of EuE and PEG400 in isopropyl alcohol and ethanol (80:20, v/v), exhibited rapid film formation within about 5 min and the dried film allowed a high skin permeability compared to other formulations due to the ability to increase the thermodynamic activity of both drugs. When triiodothyronine (T3) was loaded as a model of a very low soluble drug, tocopherol polyethylene glycol succinate (TPGS) was added as a co-solvent and it allowed for the improvement of T3 retention in the skin. Conclusions: Among the formulative variables, the nature and the amount of plasticizer represent the most critical variables to obtain an EuE-based film with satisfying physical and biopharmaceutical properties. Full article
(This article belongs to the Special Issue Emerging Trends in Skin Delivery Systems)
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Review

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14 pages, 2787 KiB  
Review
What Is the Optimal Geometry of Dissolving Microneedle Arrays? A Literature Review
by Maira Visscher, Henderik W. Frijlink and Wouter L. J. Hinrichs
Pharmaceutics 2025, 17(1), 124; https://doi.org/10.3390/pharmaceutics17010124 - 17 Jan 2025
Viewed by 1191
Abstract
The application of dissolving microneedle arrays (DMNAs) is an emerging trend in drug and vaccine delivery as an alternative for hypodermic needles or other less convenient drug administration methods. The major benefits include, amongst others, that no trained healthcare personnel is required and [...] Read more.
The application of dissolving microneedle arrays (DMNAs) is an emerging trend in drug and vaccine delivery as an alternative for hypodermic needles or other less convenient drug administration methods. The major benefits include, amongst others, that no trained healthcare personnel is required and that the recipient experiences hardly any pain during administration. However, for a successful drug or vaccine delivery from the DMNA, the microneedles should be inserted intact into the skin. A successful penetration into the upper skin layers may be challenging because of the elastic nature of the skin; therefore, a minimum insertion force is required to overcome the total resistance force of the skin. In addition, the microneedles need to stay intact, which requires a certain mechanical strength, and be able to resist the required insertion force. In addition to the type of material with which the DMNAs are produced, the geometry of the DMNAs will also have a profound effect, not only on the mechanical strength but also on the number of insertions and penetration depth into the skin. In this review, the effects of shape, aspect ratio, length, width of the base, tip diameter and angle, and spacing of DMNAs on the aforementioned effect parameters were evaluated to answer the following question: ‘What is the optimal geometry of dissolving microneedle arrays?’. Full article
(This article belongs to the Special Issue Emerging Trends in Skin Delivery Systems)
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