Nanoparticles for Multiple Drug Release
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".
Deadline for manuscript submissions: 27 November 2025 | Viewed by 5
Special Issue Editor
Interests: pyrrole macrocycles for imaging and theranostics; nanoparticles for sensing applications and drug delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Combination therapies have long been adopted as strategies to overcome drug resistance. The general principle of combination therapy is the administration of more than one drug, with an independent mechanism of action, with the aim of enhancing the efficiency of the treatment. The concept of combination therapy was first introduced in the treatment of tuberculosis to reduce the risk of resistance. However, it was not until the 1960s that this approach was proposed for the fight against cancer chemoresistance. For optimal performance, the implementation of such therapies requires the delivery of the correct combination of drugs to a specific cellular target, which minimizes undesirable side-effects. In this context, the use of nanoparticles (NPs) as platforms for the co-delivery of multiple drugs have emerged as a promising strategy. A wide range of nanoparticles has been proposed to design these delivery systems such as metallic NPs, polymeric NPs, and carbon NPs. A recent example of a dual drug release system in the treatment of microbial infections is the combination of silver nanoparticles with antibiotics. In the area of cancer, the very promising combination of antitumoral small molecules with the highly sensitive siRNA must be highlighted. Unfortunately, despite the encouraging progress accomplished, there are still many practical aspects about the design, performance, safety, and scalability of the nano-vehicles that must be addressed in order to translate the concept to the clinic. Hence, with the aim of fostering innovative research in this field and sharing novel ideas, it is our pleasure to invite you to contribute your research article, communication, or review to this Special Issue.
Prof. Dr. David Sánchez-García
Guest Editor
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Keywords
- nanoparticle
- drug delivery
- combination therapy
- chemoresistance
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