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Nanomaterials
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Recent Insights on Metal Nanomaterials for Biomedicine and Health Care
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Recent Insights on Metal Nanomaterials for Biomedicine and Health Care

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3874

Special Issue Editors

Prof. Dr. Marcin Banach

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Guest Editor
Department of Chemical Technology and Environmental Analytics, Cracow University of Technology, Cracow, Poland
Interests: nanotechnology; nanomaterials; bionanomaterials; nanozymes; green chemistry; flow chemistry; chemical engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Jolanta Pulit-Prociak

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Guest Editor
Department of Chemical Technology and Environmental Analytics, Cracow University of Technology, Cracow, Poland
Interests: nanotechnology; nanoparticle modification; waste management; green energy
Special Issues, Collections and Topics in MDPI journals
Dr. Olga Długosz

E-Mail Website
Guest Editor
Politechnika Krakowska, Krakow, Poland
Interests: nanotechnology; nanocomposites; flow chemistry; chemical engineering; sorption; photocatalysis; process control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoparticles of precious metals, in particular palladium, platinum, silver and gold, arouse interest due to their unique properties associated with, inter alia, high chemical stability and specific optical properties associated with the phenomenon of Localized Surface Plasmon Resonance (LSPR). Noble metal nanoparticles are used, for example, as photosensitizers in photothermal anticancer therapy, as drug and gene carriers and in bioimaging.

Metallic nanoparticles are also known as a leader in the fight against pathogenic microbial activity. They are characterised by high antimicrobial efficacy manifested against bacteria, viruses and fungi. Metal nanoparticles are an effective agent destroying a wide spectrum of Gram-negative and Gram-positive bacteria, they are also effective against antibiotic-resistant strains. Metallic nanoparticles are used in medicine, agriculture, veterinary medicine, food industry and cosmetology.

There is no doubt that the presence of nanoparticles in many consumer products improves quality of life in general, providing numerous useful and economic benefits. Nanoparticles have been introduced into the formulation of hundreds of different types of products, representing a breakthrough in their use.

Therefore, there is a need to present the results of original experimental or theoretical research work undertaken to acquire new knowledge used to develop technologies to obtain new nanomaterials, to modify known processes for better controlling their properties or to develop formulations that will not have harmful properties towards living matter or will reduce these properties while maintaining the functionality of materials and exceptional performance properties.

The present Special Issue of Nanomaterials will cover all aspects of most recent advances in application of metal nanoparticles in Biomedicine. Also, the scope will include novel approaches in obtaining, modifying and characterizing nanomaterials that may be applied in Bionanomedicine.

Prof. Dr. Marcin Banach
Dr. Jolanta Pulit-Prociak
Dr. Olga Długosz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial properties
  • anti-cancer effects
  • drug carriers
  • biomaterials
  • tissue regeneration
  • nanoparticles modification

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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15 pages, 3799 KiB  
Article
Nano-Formulating Besifloxacin and Employing Quercetin as a Synergizer to Enhance the Potency of Besifloxacin against Pathogenic Bacterial Strains: A Nano-Synergistic Approach
by Turki Al Hagbani, Syed Mohd Danish Rizvi, Shazi Shakil and Amr Selim Abu Lila
Nanomaterials 2023, 13(14), 2083; https://doi.org/10.3390/nano13142083 - 16 Jul 2023
Cited by 4 | Viewed by 1677
Abstract
The present study applied a nano-synergistic approach to enhance besifloxacin’s potency via nano-formulating besifloxacin on gold nanoparticles (Besi-AuNPs) and adding quercetin as a natural synergistic compound. In fact, a one-pot AuNP synthesis approach was applied for the generation of Besi-AuNPs, where besifloxacin itself [...] Read more.
The present study applied a nano-synergistic approach to enhance besifloxacin’s potency via nano-formulating besifloxacin on gold nanoparticles (Besi-AuNPs) and adding quercetin as a natural synergistic compound. In fact, a one-pot AuNP synthesis approach was applied for the generation of Besi-AuNPs, where besifloxacin itself acted as a reducing and capping agent. Characterization of Besi-AuNPs was performed by spectrophotometry, DLS, FTIR, and electron microscopy techniques. Moreover, antibacterial assessment of pure besifloxacin, Besi-AuNPs, and their combinations with quercetin were performed on Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. UV-spectra showed a peak of AuNPs at 526 nm, and the electron microscopy-based size was estimated to be 15 ± 3 nm. The effective MIC50 concentrations of besifloxacin after loading on AuNPs were reduced by approximately 50% against the tested bacterial strains. Interestingly, adding quercetin to Besi-AuNPs further enhanced their antibacterial potency, and isobologram analysis showed synergistic potential (combination index below 1) for different quercetin and Besi-AuNP combinations. However, Besi-AuNPs and quercetin combinations were most effective against Gram-positive S. aureus in comparison to Gram-negative P. aeruginosa and E. coli. Their potent activity against S. aureus has its own clinical significance, as it is one the main causative agents of ocular infection, and besifloxacin is primarily used for treating infectious eye diseases. Thus, the outcomes of the present study could be explored further to provide better medication for eye infections caused by resistant pathogens. Full article
(This article belongs to the Special Issue Recent Insights on Metal Nanomaterials for Biomedicine and Health Care)
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Review

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30 pages, 4022 KiB  
Review
Inorganic Nanomaterials Used in Anti-Cancer Therapies:Further Developments
by Olga Długosz, Wiktoria Matyjasik, Gabriela Hodacka, Krzysztof Szostak, Julia Matysik, Patrycja Krawczyk, Anna Piasek, Jolanta Pulit-Prociak and Marcin Banach
Nanomaterials 2023, 13(6), 1130; https://doi.org/10.3390/nano13061130 - 22 Mar 2023
Cited by 15 | Viewed by 3705
Abstract
In this article, we provide an overview of the progress of scientists working to improve the quality of life of cancer patients. Among the known methods, cancer treatment methods focusing on the synergistic action of nanoparticles and nanocomposites have been proposed and described. [...] Read more.
In this article, we provide an overview of the progress of scientists working to improve the quality of life of cancer patients. Among the known methods, cancer treatment methods focusing on the synergistic action of nanoparticles and nanocomposites have been proposed and described. The application of composite systems will allow precise delivery of therapeutic agents to cancer cells without systemic toxicity. The nanosystems described could be used as a high-efficiency photothermal therapy system by exploiting the properties of the individual nanoparticle components, including their magnetic, photothermal, complex, and bioactive properties. By combining the advantages of the individual components, it is possible to obtain a product that would be effective in cancer treatment. The use of nanomaterials to produce both drug carriers and those active substances with a direct anti-cancer effect has been extensively discussed. In this section, attention is paid to metallic nanoparticles, metal oxides, magnetic nanoparticles, and others. The use of complex compounds in biomedicine is also described. A group of compounds showing significant potential in anti-cancer therapies are natural compounds, which have also been discussed. Full article
(This article belongs to the Special Issue Recent Insights on Metal Nanomaterials for Biomedicine and Health Care)
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22 pages, 2558 KiB  
Review
Antimicrobial Activity of Graphene-Based Nanocomposites: Synthesis, Characterization, and Their Applications for Human Welfare
by Varish Ahmad and Mohammad Omaish Ansari
Nanomaterials 2022, 12(22), 4002; https://doi.org/10.3390/nano12224002 - 14 Nov 2022
Cited by 13 | Viewed by 3177
Abstract
Graphene (GN)-related nanomaterials such as graphene oxide, reduced graphene oxide, quantum dots, etc., and their composites have attracted significant interest owing to their efficient antimicrobial properties and thus newer GN-based composites are being readily developed, characterized, and explored for clinical applications by scientists [...] Read more.
Graphene (GN)-related nanomaterials such as graphene oxide, reduced graphene oxide, quantum dots, etc., and their composites have attracted significant interest owing to their efficient antimicrobial properties and thus newer GN-based composites are being readily developed, characterized, and explored for clinical applications by scientists worldwide. The GN offers excellent surface properties, i.e., a large surface area, pH sensitivity, and significant biocompatibility with the biological system. In recent years, GN has found applications in tissue engineering owing to its impressive stiffness, mechanical strength, electrical conductivity, and the ability to innovate in two-dimensional (2D) and three-dimensional (3D) design. It also offers a photothermic effect that potentiates the targeted killing of cells via physicochemical interactions. It is generally synthesized by physical and chemical methods and is characterized by modern and sophisticated analytical techniques such as NMR, Raman spectroscopy, electron microscopy, etc. A lot of reports show the successful conjugation of GN with existing repurposed drugs, which improves their therapeutic efficacy against many microbial infections and also its potential application in drug delivery. Thus, in this review, the antimicrobial potentialities of GN-based nanomaterials, their synthesis, and their toxicities in biological systems are discussed. Full article
(This article belongs to the Special Issue Recent Insights on Metal Nanomaterials for Biomedicine and Health Care)
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