Special Issue "Biomimetic and Bioinspired Nanomaterials/Nanostructures and Their Application"

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 July 2021).

Special Issue Editors

Dr. Ion N. Mihailescu
E-Mail Website
Guest Editor
Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania
Interests: pulsed laser deposition; modification and characterization of nanostructured thin coatings; matrix assisted pulsed laser evaporation (MAPLE); laser surface studies and processing; biomaterials thin layers; tissue engineering; biomimetic metallic implants; optoelectronics and sensors
Special Issues and Collections in MDPI journals
Dr. Carmen Ristoscu
E-Mail Website
Guest Editor
National Institute for Lasers, Plasma and Radiation Physics, 077125 Măgurele, Romania
Interests: experimental optics; spectroscopy; lasers and plasma; surface studies and processing with laser; laser interactions; lasers and plasma physics; nanostructured thin films technology (PLD, MAPLE and combinatorial); surface physics and engineering; biophysics and biomedicine; nano- bio- technologies; gas- and bio- sensors; plasma and laser theory
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The significant and continuous increase in hope for life all around the world generated a huge interest towards biomaterials for fixing or replacing damaged vivid tissues, for the controlled administration of drugs, and for new advanced biosensors. However, it became obvious very soon that the new biomaterials should reproduce the natural ones, not only in composition, but also in structure, morphology, and especially functionality. All efforts were accordingly pushed towards to new concepts of biomimetics (biomimicry) and bioinspiration. The first case is the imitation of models, systems, and elements of nature, while the design and production of novel materials, devices, and structures, inspired by solutions found in nature, is intended to be the second one.

Different from biomimicry, bioinspired products are designed starting from the origins of nature, by studying the remarkable functions of organisms, and then imitating them. The domain was potentiated by the recent progress of nanomaterials and the advent of metamaterials, which largely diversified and extended the approachable research topics.

We therefore decided to launch a Special Issue devoted to "Biomimetic and Bioinspired Nanomaterials/Nanostructures", with special emphasis on thin films and nanoparticles. The purpose is to continue the active, hot dialog on these topics. A special stimulus comes from the cancelation of all major international meetings in the field caused by the recent world sanitary crisis.

Here follows a list of suggested topics:

  1. Biomimetic materials and functional surfaces for biomedical applications at nanoscale
  2. Biomimetics and bionic engineering
  3. Recent progress in Biophotonics
  4. Structure and mechanics of nature bioinspired materials
  5. Application and performance of bioinspired materials
  6. Synthesis of biomimetic nanoparticles, nanocomposites, and natural products
  7. Biodegradability and mechanical properties of biomimetic nanostructures
  8. Biomimetic approach in inorganic material chemistry
  9. Sustainable biomaterials

Prof. Dr. Ion N. Mihailescu
Dr. Carmen Ristoscu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Research

Article
Chitosan Covalently Functionalized with Peptides Mapped on Vitronectin and BMP-2 for Bone Tissue Engineering
Nanomaterials 2021, 11(11), 2784; https://doi.org/10.3390/nano11112784 - 21 Oct 2021
Viewed by 179
Abstract
Worldwide, over 20 million patients suffer from bone disorders annually. Bone scaffolds are designed to integrate into host tissue without causing adverse reactions. Recently, chitosan, an easily available natural polymer, has been considered a suitable scaffold for bone tissue growth as it is [...] Read more.
Worldwide, over 20 million patients suffer from bone disorders annually. Bone scaffolds are designed to integrate into host tissue without causing adverse reactions. Recently, chitosan, an easily available natural polymer, has been considered a suitable scaffold for bone tissue growth as it is a biocompatible, biodegradable, and non-toxic material with antimicrobial activity and osteoinductive capacity. In this work, chitosan was covalently and selectively biofunctionalized with two suitably designed bioactive synthetic peptides: a Vitronectin sequence (HVP) and a BMP-2 peptide (GBMP1a). Nuclear magnetic resonance (NMR), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FT-IR) investigations highlighted the presence of the peptides grafted to chitosan (named Chit-HVP and Chit-GBMP1a). Chit-HVP and Chit-GBMP1a porous scaffolds promoted human osteoblasts adhesion, proliferation, calcium deposition, and gene expression of three crucial osteoblast proteins. In particular, Chit-HVP highly promoted adhesion and proliferation of osteoblasts, while Chit-GBMP1a guided cell differentiation towards osteoblastic phenotype. Full article
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Article
Resveratrol-Loaded Levan Nanoparticles Produced by Electrohydrodynamic Atomization Technique
Nanomaterials 2021, 11(10), 2582; https://doi.org/10.3390/nano11102582 - 30 Sep 2021
Viewed by 286
Abstract
Considering the significant advances in nanostructured systems in various biomedical applications and the escalating need for levan-based nanoparticles as delivery systems, this study aimed to fabricate levan nanoparticles by the electrohydrodynamic atomization (EHDA) technique. The hydrolyzed derivative of levan polysaccharide from Halomonas smyrnensis [...] Read more.
Considering the significant advances in nanostructured systems in various biomedical applications and the escalating need for levan-based nanoparticles as delivery systems, this study aimed to fabricate levan nanoparticles by the electrohydrodynamic atomization (EHDA) technique. The hydrolyzed derivative of levan polysaccharide from Halomonas smyrnensis halophilic bacteria, hydrolyzed Halomonas levan (hHL), was used. Nanoparticles were obtained by optimizing the EHDA parameters and then they were characterized in terms of morphology, molecular interactions, drug release and cell culture studies. The optimized hHL and resveratrol (RS)-loaded hHL nanoparticles were monodisperse and had smooth surfaces. The particle diameter size of hHL nanoparticles was 82.06 ± 15.33 nm. Additionally, release of RS from the fabricated hHL nanoparticles at different pH conditions were found to follow the first-order release model and hHL with higher RS loading showed a more gradual release. In vitro biocompatibility assay with human dermal fibroblast cell lines was performed and cell behavior on coated surfaces was observed. Nanoparticles were found to be safe for healthy cells. Consequently, the fabricated hHL-based nanoparticle system may have potential use in drug delivery systems for wound healing and tissue engineering applications and surfaces could be coated with these electrosprayed particles to improve cellular interaction. Full article
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Article
Size-Dependent Internalization Efficiency of Macrophages from Adsorbed Nanoparticle-Based Monolayers
Nanomaterials 2021, 11(8), 1963; https://doi.org/10.3390/nano11081963 - 30 Jul 2021
Viewed by 476
Abstract
Functional coatings based on the assembly of submicrometric or nanoparticles are found in many applications in the biomedical field. However, these nanoparticle-based coatings are particularly fragile since they could be exposed to cells that are able to internalize nanoparticles. Here, we studied the [...] Read more.
Functional coatings based on the assembly of submicrometric or nanoparticles are found in many applications in the biomedical field. However, these nanoparticle-based coatings are particularly fragile since they could be exposed to cells that are able to internalize nanoparticles. Here, we studied the efficiency of RAW 264.7 murine macrophages to internalize physisorbed silica nanoparticles as a function of time and particle size. This cell internalization efficiency was evaluated from the damages induced by the cells in the nanoparticle-based monolayer on the basis of scanning electron microscopy and confocal laser scanning microscopy observations. The internalization efficiency in terms of the percentage of nanoparticles cleared from the substrate is characterized by two size-dependent regimes. Additionally, we highlighted that a delay before internalization occurs, which increases with decreasing adsorbed nanoparticle size. This internalization is characterized by a minimal threshold that corresponds to 35 nm nanoparticles that are not internalized during the 12-h incubation considered in this work. Full article
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Article
Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments
Nanomaterials 2021, 11(4), 996; https://doi.org/10.3390/nano11040996 - 13 Apr 2021
Viewed by 522
Abstract
In pharmaceutical development, more and more drugs are classified as poorly water-soluble or insoluble. Particle size reduction is a common way to fight this trend by improving dissolution rate, transport characteristics and bioavailability. Pulsed laser ablation is a ground-breaking technique of drug particle [...] Read more.
In pharmaceutical development, more and more drugs are classified as poorly water-soluble or insoluble. Particle size reduction is a common way to fight this trend by improving dissolution rate, transport characteristics and bioavailability. Pulsed laser ablation is a ground-breaking technique of drug particle generation in the nano- and micrometer size range. Meloxicam, a commonly used nonsteroidal anti-inflammatory drug with poor water solubility, was chosen as the model drug. The pastille pressed meloxicam targets were irradiated by a Ti:sapphire laser (τ = 135 fs, λc = 800 nm) in air and in distilled water. Fourier transform infrared and Raman spectroscopies were used for chemical characterization and scanning electron microscopy to determine morphology and size. Additional particle size studies were performed using a scanning mobility particle sizer. Our experiments demonstrated that significant particle size reduction can be achieved with laser ablation both in air and in distilled water without any chemical change of meloxicam. The size of the ablated particles (~50 nm to a few microns) is approximately at least one-tenth of the size (~10–50 micron) of commercially available meloxicam crystals. Furthermore, nanoaggregate formation was described during pulsed laser ablation in air, which was scarcely studied for drug/organic molecules before. Full article
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