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Article

Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments

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Department of Optics and Quantum Electronics, University of Szeged, Dóm tér 9, 6720 Szeged, Hungary
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Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös utca 6, 6720 Szeged, Hungary
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Interdisciplinary Excellence Centre, Department of Materials Science, University of Szeged, Dugonics tér 13, 6720 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Academic Editors: Ion N. Mihailescu and Carmen Ristoscu
Nanomaterials 2021, 11(4), 996; https://doi.org/10.3390/nano11040996
Received: 22 March 2021 / Revised: 9 April 2021 / Accepted: 9 April 2021 / Published: 13 April 2021
In pharmaceutical development, more and more drugs are classified as poorly water-soluble or insoluble. Particle size reduction is a common way to fight this trend by improving dissolution rate, transport characteristics and bioavailability. Pulsed laser ablation is a ground-breaking technique of drug particle generation in the nano- and micrometer size range. Meloxicam, a commonly used nonsteroidal anti-inflammatory drug with poor water solubility, was chosen as the model drug. The pastille pressed meloxicam targets were irradiated by a Ti:sapphire laser (τ = 135 fs, λc = 800 nm) in air and in distilled water. Fourier transform infrared and Raman spectroscopies were used for chemical characterization and scanning electron microscopy to determine morphology and size. Additional particle size studies were performed using a scanning mobility particle sizer. Our experiments demonstrated that significant particle size reduction can be achieved with laser ablation both in air and in distilled water without any chemical change of meloxicam. The size of the ablated particles (~50 nm to a few microns) is approximately at least one-tenth of the size (~10–50 micron) of commercially available meloxicam crystals. Furthermore, nanoaggregate formation was described during pulsed laser ablation in air, which was scarcely studied for drug/organic molecules before. View Full-Text
Keywords: poorly water-soluble drug(s); preformulation; particle size; nanoparticle(s); nanosphere(s) poorly water-soluble drug(s); preformulation; particle size; nanoparticle(s); nanosphere(s)
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MDPI and ACS Style

Nagy, E.; Andrásik, A.; Smausz, T.; Ajtai, T.; Kun-Szabó, F.; Kopniczky, J.; Bozóki, Z.; Szabó-Révész, P.; Ambrus, R.; Hopp, B. Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments. Nanomaterials 2021, 11, 996. https://doi.org/10.3390/nano11040996

AMA Style

Nagy E, Andrásik A, Smausz T, Ajtai T, Kun-Szabó F, Kopniczky J, Bozóki Z, Szabó-Révész P, Ambrus R, Hopp B. Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments. Nanomaterials. 2021; 11(4):996. https://doi.org/10.3390/nano11040996

Chicago/Turabian Style

Nagy, Eszter, Attila Andrásik, Tamás Smausz, Tibor Ajtai, Fruzsina Kun-Szabó, Judit Kopniczky, Zoltán Bozóki, Piroska Szabó-Révész, Rita Ambrus, and Béla Hopp. 2021. "Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments" Nanomaterials 11, no. 4: 996. https://doi.org/10.3390/nano11040996

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