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Nanomaterials
Special Issues
Nanostructured Materials and Coatings for Biomedical Applications
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Nanostructured Materials and Coatings for Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 28 November 2025 | Viewed by 17189

Special Issue Editors

Dr. Federica Paladini

E-Mail Website
Guest Editor
Department of Experimental Medicine, University of Salento, Via per Monteroni, 73100 Lecce, Italy
Interests: bioengineering; tissue engineering; silk/protein-based biomaterials; surface functionalization; antimicrobial nanocoatings
Special Issues, Collections and Topics in MDPI journals
Dr. Carola Esposito Corcione

E-Mail Website
Guest Editor
Department of Innovation Engineering, University of Salento, Via per Monteroni, 73100 Lecce, Italy
Interests: coatings; nanomaterials; 3D printing; circular economy; polymers; nanocomposites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanotechnology represents a new frontier in the biomedical field regarding the development of novel materials and devices, as well as in diagnosis and imaging techniques.

At the nanometric scales, some materials show distinct properties and functionalities that can be exploited for many different biomedical applications, including the development of nanostructured scaffolds for tissue engineering, nanosystems for the delivery of drugs and bioactive molecules, nanometric coatings with antimicrobial properties and improved bioactivity for specific medical purposes. In this regard, this Special Issue aims at collecting the most recent progress in the development of nanotechnology-based approaches for providing new therapeutic options and new effective tools for treating specific diseases, with a special focus on the development of nanostructured materials and coatings and their mechanisms of interaction with the biological world.

Dr. Federica Paladini
Dr. Carola Esposito Corcione
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • nanocoatings
  • drug delivery
  • antimicrobial nanoparticles
  • bioactive
  • biomedical
  • surface functionalization

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Published Papers (3 papers)

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Research

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13 pages, 1947 KiB  
Article
Photothermal Performance of 2D Material-Based Nanoparticles for Biomedical Applications
by Amir Eghbali, Nikolay V. Pak, Aleksey V. Arsenin, Valentyn Volkov and Andrey A. Vyshnevyy
Nanomaterials 2025, 15(12), 942; https://doi.org/10.3390/nano15120942 - 18 Jun 2025
Viewed by 277
Abstract
Photothermal therapy (PTT) is one of the rapidly developing methods for cancer treatment based on the strong light-to-heat conversion by nanoparticles. Over the past decade, the palette of photonic materials has expanded drastically, and nanoparticle fabrication techniques can now preserve the optical response [...] Read more.
Photothermal therapy (PTT) is one of the rapidly developing methods for cancer treatment based on the strong light-to-heat conversion by nanoparticles. Over the past decade, the palette of photonic materials has expanded drastically, and nanoparticle fabrication techniques can now preserve the optical response of a bulk material in produced nanoparticles. This progress potentially holds opportunities for the efficiency enhancement of PTT, which have not fully explored yet. Here we study the photothermal performance of spherical nanoparticles (SNs) composed of novel two-dimensional (2D) and conventional materials with existing or potential applications in photothermal therapy such as MoS2, PdSe2, Ti3C2, TaS2, and TiN. Using the Mie theory, we theoretically analyze the optical response of SNs across various radii of 5–100 nm in the near-infrared (NIR) region with a particular focus on the therapeutic NIR-II range (1000–1700 nm) and radii below 50 nm. Our calculations reveal distinct photothermal behaviors: Large (radius > 50 nm) nanoparticles made of van der Waals semiconductors and PdSe2 perform exceptionally well in the NIR-I range (750–950 nm) due to excitonic optical responses, while Ti3C2 nanoparticles achieve broad effectiveness across both NIR zones due to their dual dielectric/plasmonic properties. Small TiN SNs excel in the NIR-I zone due to the plasmonic response of TiN at shorter wavelengths. Notably, the van der Waals metal TaS2 emerges as the most promising photothermal transduction agent in the NIR-II region, particularly for smaller nanoparticles, due to its plasmonic resonance. Our insights lay a foundation for designing efficient photothermal transduction agents, with significant implications for cancer therapy and other biomedical applications. Full article
(This article belongs to the Special Issue Nanostructured Materials and Coatings for Biomedical Applications)
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13 pages, 1676 KiB  
Article
Biological Evaluation of Silver-Treated Silk Fibroin Scaffolds for Application as Antibacterial and Regenerative Wound Dressings
by Federica Paladini, Carmen Lanzillotti, Angelica Panico and Mauro Pollini
Nanomaterials 2025, 15(12), 919; https://doi.org/10.3390/nano15120919 - 13 Jun 2025
Viewed by 354
Abstract
Chronic wounds represent a major clinical challenge due to their prolonged healing process and susceptibility to bacterial colonization, particularly by biofilm-forming bacteria. To address these issues, in this work, silver-treated silk fibroin scaffolds were developed and tested as multifunctional wound dressings, combining antimicrobial [...] Read more.
Chronic wounds represent a major clinical challenge due to their prolonged healing process and susceptibility to bacterial colonization, particularly by biofilm-forming bacteria. To address these issues, in this work, silver-treated silk fibroin scaffolds were developed and tested as multifunctional wound dressings, combining antimicrobial and regenerative properties. Silk fibroin, a natural protein derived from Bombyx mori cocoons, is widely recognized for its biocompatibility and suitability for tissue engineering. In this study, porous silk fibroin scaffolds were functionalized with silver nanoparticles through a photo-reduction process and were comprehensively tested for their cytocompatibility and wound healing potential. The excellent antibacterial activity of the silver-treated scaffolds was demonstrated against Escherichia coli and antibiotic-resistant Pseudomonas aeruginosa, as was extensively reported in a previous work. Biological assays were performed using 3T3 fibroblasts cultured on both untreated and silver-treated silk fibroin scaffolds. Biocompatibility assays, such as MTT, Live/Dead, and cytoskeleton analyses, demonstrated biocompatibility in both scaffold types, comparable to the control. Wound healing potential was assessed using in vitro scratch assays, revealing full wound closure (100%) after 24 h in cells cultured with untreated and silver-treated silk fibroin scaffolds, in contrast to 78.5% closure in the control. Notably, silver-treated scaffolds exhibited enhanced fibroblast repopulation within the wound gap, suggesting a synergistic effect of silver and fibroin in promoting tissue regeneration. These findings demonstrate that silver-treated silk fibroin scaffolds possess both anti-microbial and regenerative properties, making them promising candidates for chronic wound management applications. Full article
(This article belongs to the Special Issue Nanostructured Materials and Coatings for Biomedical Applications)
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Review

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44 pages, 3330 KiB  
Review
Silver Nanoparticles: A Comprehensive Review of Synthesis Methods and Chemical and Physical Properties
by Hatice Duman, Furkan Eker, Emir Akdaşçi, Anna Maria Witkowska, Mikhael Bechelany and Sercan Karav
Nanomaterials 2024, 14(18), 1527; https://doi.org/10.3390/nano14181527 - 20 Sep 2024
Cited by 45 | Viewed by 16016
Abstract
Recently, silver nanoparticles (NPs) have attracted significant attention for being highly desirable nanomaterials in scientific studies as a result of their extraordinary characteristics. They are widely known as effective antibacterial agents that are capable of targeting a wide range of pathogens. Their distinct [...] Read more.
Recently, silver nanoparticles (NPs) have attracted significant attention for being highly desirable nanomaterials in scientific studies as a result of their extraordinary characteristics. They are widely known as effective antibacterial agents that are capable of targeting a wide range of pathogens. Their distinct optical characteristics, such as their localized surface plasmon resonance, enlarge their utilization, particularly in the fields of biosensing and imaging. Also, the capacity to control their surface charge and modify them using biocompatible substances offers improved durability and specific interactions with biological systems. Due to their exceptional stability and minimal chemical reactivity, silver NPs are highly suitable for a diverse array of biological applications. These NPs are produced through chemical, biological, and physical processes, each of which has distinct advantages and disadvantages. Chemical and physical techniques often encounter issues with complicated purification, reactive substances, and excessive energy usage. However, eco-friendly biological approaches exist, even though they require longer processing times. A key factor affecting the stability, size distribution, and purity of the NPs is the synthesis process selected. This review focuses on how essential it is to choose the appropriate synthesis method in order to optimize the characteristics and use of silver NPs. Full article
(This article belongs to the Special Issue Nanostructured Materials and Coatings for Biomedical Applications)
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