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Biomimetics
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Bioinspired Materials for Tissue Engineering
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Bioinspired Materials for Tissue Engineering

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 7590

Special Issue Editors

Prof. Dr. Mauro Pollini

E-Mail Website
Guest Editor
Department of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, Italy
Interests: tissue engineering; bioengineering; antibacterial treatments; silver; fibroin; sericin; nanocoatings
Special Issues, Collections and Topics in MDPI journals
Dr. Federica Paladini

E-Mail Website
Guest Editor
Department of Experimental Medicine, University of Salento, Via per Monteroni, 73100 Lecce, Italy
Interests: bioengineering; tissue engineering; silk/protein-based biomaterials; surface functionalization; antimicrobial nanocoatings
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue engineering and regenerative medicine are important interdisciplinary fields aiming to define efficient strategies for repairing and restoring the structural integrity and functionality of damaged tissues and organs. Involving different research areas, such as medicine, biology, chemistry, and bioengineering, tissue engineering has recent advanced towards a growing range of clinical needs, supported by progress in the design and development of novel biomaterials with specific properties for specific applications.

Bioinspired materials, including biodegradable polymers, hydrogels, composite materials, proteins, etc., properly designed for tissue engineering applications, along with their processing and characterization techniques, are the focus of this Special Issue. In particular, this Special Issue aims to collect the most recent and interesting advances in the field of tissue engineering and regenerative medicine in order to provide readers, researchers, and clinicians with an overview of the scientific progress in this field that can open new horizons in the definition of novel approaches for the treatment of many medical issues.

Prof. Dr. Mauro Pollini
Prof. Dr. Federica Paladini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • regenerative medicine
  • bioinspired
  • biomaterials
  • scaffold
  • hydrogel

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Published Papers (6 papers)

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Research

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15 pages, 2840 KiB  
Article
In Vivo Vascularization of Cell-Supplemented Spider Silk-Based Hydrogels in the Arteriovenous Loop Model
by Justus Osterloh, Stefanie Heltmann-Meyer, Vanessa T. Trossmann, Aijia Cai, Yvonne Kulicke, Klara Terörde, Celena A. Sörgel, Isabell Lang, Harald Wajant, Thomas Scheibel, Tobias Fey, Dominik Steiner, Andreas Arkudas and Raymund E. Horch
Biomimetics 2025, 10(2), 117; https://doi.org/10.3390/biomimetics10020117 - 18 Feb 2025
Viewed by 490
Abstract
The goal of reconstructive surgery in treating tissue defects is to achieve a stable reconstructive outcome while minimizing donor site morbidity. As a result, tissue engineering has emerged as a key focus in the pursuit of this goal. One approach is to create [...] Read more.
The goal of reconstructive surgery in treating tissue defects is to achieve a stable reconstructive outcome while minimizing donor site morbidity. As a result, tissue engineering has emerged as a key focus in the pursuit of this goal. One approach is to create a tissue container that can be preconditioned and later transplanted into the defect area. The characteristics of the matrices used in the tissue container are critical to this approach’s success. Matrices generated with recombinant, functionalized spider silk (eADF4(C16)-RGD) have been reported to be biocompatible and easy to vascularize. However, the effect of exogenously added proangiogenic cells, such as endothelial cells (T17b), on the vascularization process of matrices generated with this hydrogel in vivo has not been described yet. In this study, we implanted arteriovenous (AV) loop containers filled with a spider silk hydrogel consisting of an eADF4(C16)-RGD matrix and encapsulated, differentiated endothelial T17b cells producing the reporter protein TNFR2-Fc-Flag-GpL. The histological and µCT analyses revealed spontaneous angiogenesis and fibrovascular tissue formation in the container at 2 and 4 weeks post-implantation. The reporter protein was detected after 4 weeks. No severe immune response was observed. Altogether, this study demonstrates that cell-supplemented recombinant spider silk is a highly promising hydrogel to produce matrices for tissue engineering applications. Full article
(This article belongs to the Special Issue Bioinspired Materials for Tissue Engineering)
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13 pages, 1868 KiB  
Article
Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures
by Maria C. Arango, Leander Vásquez Vásquez, Akemy Carolina Homma Parra, Santiago Rueda-Mira, Natalia Jaramillo-Quiceno, Josep Pasqual Cerisuelo, Amparo Cháfer and Catalina Álvarez-López
Biomimetics 2025, 10(1), 27; https://doi.org/10.3390/biomimetics10010027 - 5 Jan 2025
Viewed by 807
Abstract
Fibrous by-products, including defective or double cocoons, are obtained during silk processing. These cocoons primarily contain fibroin and sericin (SS) proteins along with minor amounts of wax and mineral salts. In conventional textile processes, SS is removed in the production of smooth, lustrous [...] Read more.
Fibrous by-products, including defective or double cocoons, are obtained during silk processing. These cocoons primarily contain fibroin and sericin (SS) proteins along with minor amounts of wax and mineral salts. In conventional textile processes, SS is removed in the production of smooth, lustrous silk threads, and is typically discarded. However, SS has garnered attention for its antioxidant, antibacterial, biocompatible, and anticancer properties as well as its excellent moisture absorption, making it a promising polymer for biomedical applications. Owing to its functional groups (carboxyl, amino, and hydroxyl), SS can blend and crosslink with other polymers, thereby improving the mechanical properties of sericin-based materials. This study explored the effects of different SS/polyvinyl alcohol (PVA) ratios on porous scaffolds fabricated via freeze-drying, focusing on the mechanical stability, water absorption, and protein release in phosphate-buffered saline (PBS). The scaffold morphology revealed reduced porosity with higher SS content, while increased PVA content led to material folding and layering. A greater PVA content enhanced water absorption, mechanical properties, and thermal stability, although SS release decreased. These results demonstrate that scaffold properties can be tailored by optimizing the SS/PVA ratio to suit specific biomedical applications. Full article
(This article belongs to the Special Issue Bioinspired Materials for Tissue Engineering)
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13 pages, 3188 KiB  
Article
Silver-Treated Silk Fibroin Scaffolds for Prevention of Critical Wound Infections
by Federica Paladini, Francesca Russo, Annalia Masi, Carmen Lanzillotti, Alessandro Sannino and Mauro Pollini
Biomimetics 2024, 9(11), 659; https://doi.org/10.3390/biomimetics9110659 - 29 Oct 2024
Viewed by 1247
Abstract
The risk of infections in chronic wounds represents a serious issue, particularly in aged people and in patients affected by diseases such as diabetes and obesity. Moreover, the growing resistance demonstrated by many bacterial strains has significantly reduced the therapeutic options for clinicians [...] Read more.
The risk of infections in chronic wounds represents a serious issue, particularly in aged people and in patients affected by diseases such as diabetes and obesity. Moreover, the growing resistance demonstrated by many bacterial strains has significantly reduced the therapeutic options for clinicians and has become a great challenge for the researchers in the definition of novel approaches that promote the wound healing process and reduce the healing time. Tissue engineering approaches based on biomaterials and three-dimensional scaffolds have demonstrated huge potential in supporting cell proliferation; among them, Bombyx mori-derived silk fibroin is a very appealing possibility for the development of devices with regenerative properties for wound healing applications. However, due to the high risk of infections in chronic wounds, an antibacterial treatment is also strongly encouraged for preventing bacterial proliferation at the wound site. In this work, to develop a device with regenerative and antibacterial properties, antibacterial silver coatings were deposited onto silk fibroin scaffolds, and the effect of the treatment in terms of chemical–physical and microbiological properties was investigated. The results demonstrated that the silver treatment improved the mechanical properties of the protein scaffold and provided good antibacterial efficacy against representative bacterial strains in wound infection, namely Escherichia coli and antibiotic-resistant Pseudomonas aeruginosa. Full article
(This article belongs to the Special Issue Bioinspired Materials for Tissue Engineering)
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Review

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14 pages, 252 KiB  
Review
Applications of Platelet-Rich Fibrin (PRF) Membranes Alone or in Combination with Biomimetic Materials in Oral Regeneration: A Narrative Review
by Javier Valenzuela-Mencia and Francisco Javier Manzano-Moreno
Biomimetics 2025, 10(3), 172; https://doi.org/10.3390/biomimetics10030172 - 11 Mar 2025
Viewed by 612
Abstract
Platelet-rich fibrin (PRF) membranes are a biomaterial derived from the patient’s own blood, used in different medical and dental areas for their ability to promote healing, tissue regeneration, and reduce inflammation. They are obtained by centrifuging the blood, which separates the components and [...] Read more.
Platelet-rich fibrin (PRF) membranes are a biomaterial derived from the patient’s own blood, used in different medical and dental areas for their ability to promote healing, tissue regeneration, and reduce inflammation. They are obtained by centrifuging the blood, which separates the components and concentrates the platelets and growth factors in a fibrin matrix. This material is then moulded into a membrane that can be applied directly to tissues. The use of these PRF membranes is often associated with the use of different biomimetic materials such as deproteinized bovine bone mineral (DBBM), β-tricalcium phosphate (β-TCP), enamel matrix derivative (EMD), and hydroxyapatite (HA). Different indications of PRF membranes have been proposed, like alveolar ridge preservation, alveolar ridge augmentation, guided tissue regeneration (GTR), and sinus floor augmentation. The aim of this narrative review is to check the state-of-the-art and to analyze the existing gaps in the use of PRF membranes in combination with biomimetic materials in alveolar ridge preservation, alveolar ridge augmentation, guided tissue regeneration (GTR), and sinus floor augmentation. Full article
(This article belongs to the Special Issue Bioinspired Materials for Tissue Engineering)

Other

Jump to: Research, Review

17 pages, 879 KiB  
Systematic Review
Maxillary Sinus Augmentation with Autogenous Tooth Grafting Material: A Systematic Review
by Diba Ghodsian, Sofía D’Jesús, Luis Sánchez-Labrador, Carlos Manuel Cobo-Vázquez, Jorge Cortés-Bretón Brinkmann, José María Martínez-González and Cristina Meniz-García
Biomimetics 2024, 9(9), 518; https://doi.org/10.3390/biomimetics9090518 - 29 Aug 2024
Cited by 2 | Viewed by 1876
Abstract
The aim of this systematic review was to determine whether autogenous tooth grafting material (ATGM) is as safe and effective as other bone substitutes used for maxillary sinus augmentation procedures, evaluating histomorphometric and/or histological data, implant primary stability, associated complications and radiographic bone [...] Read more.
The aim of this systematic review was to determine whether autogenous tooth grafting material (ATGM) is as safe and effective as other bone substitutes used for maxillary sinus augmentation procedures, evaluating histomorphometric and/or histological data, implant primary stability, associated complications and radiographic bone height measurements. An automated electronic search was conducted using four databases (Medline/PubMed, Scopus, Web of Science and Cochrane Library), supplemented by a manual search, to identify clinical human studies using particulate ATGM for the aforementioned procedure. The included studies had a sample size of at least four patients and were published before 31st July 2024. The Newcastle–Ottawa scale (NOS) and Joanna Briggs Institute (JBI) Critical Appraisal Checklist were used to assess the risk of bias in cohort studies and case series, respectively. Seven studies were included in the descriptive analysis, obtaining 128 participants (46.8% only treated with ATGM) and 192 placed implants. Due to the heterogeneity of the studies, meta-analysis could not be performed. The authors concluded that ATGM appears to be a feasible and safe alternative for maxillary sinus augmentation procedures. These results should be interpreted with caution due to the limited amount of scientific evidence on this topic and the heterogeneity between the included studies. Full article
(This article belongs to the Special Issue Bioinspired Materials for Tissue Engineering)
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14 pages, 712 KiB  
Systematic Review
A Systematic Review of Human Amnion Enhanced Cartilage Regeneration in Full-Thickness Cartilage Defects
by Nur Farah Anis Abd Halim, Atiqah Ab Aziz, Sik-Loo Tan, Veenesh Selvaratnam and Tunku Kamarul
Biomimetics 2024, 9(7), 383; https://doi.org/10.3390/biomimetics9070383 - 25 Jun 2024
Viewed by 1743
Abstract
Cartilage defects present a significant challenge in orthopedic medicine, often leading to pain and functional impairment. To address this, human amnion, a naturally derived biomaterial, has gained attention for its potential in enhancing cartilage regeneration. This systematic review aims to evaluate the efficacy [...] Read more.
Cartilage defects present a significant challenge in orthopedic medicine, often leading to pain and functional impairment. To address this, human amnion, a naturally derived biomaterial, has gained attention for its potential in enhancing cartilage regeneration. This systematic review aims to evaluate the efficacy of human amnion in enhancing cartilage regeneration for full-thickness cartilage defects. An electronic search was conducted on MEDLINE-PubMed, Web of Science (WoS), and the Scopus database up to 27 December 2023 from 2007. A total of 401 articles were identified. After removing 125 duplicates and excluding 271 articles based on predetermined criteria, only 5 articles remained eligible for inclusion in this systematic review. All five eligible articles conducted in vivo studies utilizing rabbits as subjects. Furthermore, analysis of the literature reveals an increasing trend in the frequency of utilizing human amnion for the treatment of cartilage defects. Various forms of human amnion were utilized either alone or seeded with cells prior to implantation. Histological assessments and macroscopic observations indicated usage of human amnion improved cartilage repair outcomes. All studies highlighted the positive results despite using different forms of amnion tissues. This systematic review underscores the promising role of human amnion as a viable option for enhancing cartilage regeneration in full-thickness cartilage defects, thus offering valuable insights for future research and clinical applications in orthopedic tissue engineering. Full article
(This article belongs to the Special Issue Bioinspired Materials for Tissue Engineering)
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