Smart Nanodevices for Therapy: Present and Future Perspectives

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 15 November 2026 | Viewed by 1735

Special Issue Editor


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Research Institute on Terrestrial Ecosystems (IRET)—CNR, Via Pietro Castellino, 80131 Naples, Italy
Interests: nanomaterial synthesis and characterization; tissue regeneration; cell toxicology
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Special Issue Information

Dear Colleagues,

This Special Issue, titled “Smart Nanodevices for Therapy: Present and Future Perspectives”, explores the cutting-edge advancements in nanotechnology in medicine. The convergence of nanotechnology with medicine has led to the development of highly sophisticated and efficient therapeutic strategies, promising significant improvements in patient outcomes. Key topics covered in this Special Issue include the design and functionalization of nanodevices for targeted drug delivery; innovations in materials used for the production of nanoparticle-based drug carriers in the form of liposomes, dendrimers, micelles, nanotubes, nanorods, polymeric nanoparticles, etc.; and stimuli-responsive nanodevices that can release therapeutic agents in response to specific conditions, ensuring on-demand drug release and enhanced therapeutic efficacy. The application of nanodevices will also be a focal point, with articles addressing the use of nanoparticles for tumor imaging, photothermal therapy, immunotherapy, regenerative medicine, tissue engineering, and the delivery of growth factors to promote tissue repair and regeneration. Emerging trends and future perspectives in the field will also be covered, emphasizing the potential of nanodevices for use in personalized medicine. The ability to tailor nanodevices to individual patient profiles can revolutionize treatment approaches, making them more effective and reducing adverse effects. Additionally, the ethical and regulatory challenges associated with the clinical translation of nanodevices will be discussed, highlighting the need for rigorous safety evaluations and standardized protocols.

In this Special Issue, original research articles, reviews, and case studies that highlight the role of smart nanodevices in diagnosing, treating, and monitoring various diseases are welcome.

Dr. Raffaele Conte
Guest Editor

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Keywords

  • nanotechnology
  • targeted drug delivery
  • stimuli-responsive nanodevices
  • cancer therapy
  • regenerative medicine
  • personalized medicine
  • ethical and regulatory challenges

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Published Papers (1 paper)

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Review

23 pages, 3668 KB  
Review
Nanodevice Approaches for Detecting Micro- and Nanoplastics in Complex Matrices
by Rita Paola Debri, Fabrizia Sepe, Silvia Romano, Nicolantonio D’Orazio, Antonino De Lorenzo, Anna Calarco, Raffaele Conte and Gianfranco Peluso
Nanomaterials 2026, 16(1), 55; https://doi.org/10.3390/nano16010055 - 31 Dec 2025
Cited by 2 | Viewed by 1365
Abstract
Micro- and nanoplastics (MNPs) are increasingly recognized as pervasive environmental contaminants with profound implications for ecosystems and human health. Their small size, compositional diversity, and occurrence across complex matrices—including water, soil, food, and biological samples—pose substantial analytical challenges. Conventional techniques such as vibrational [...] Read more.
Micro- and nanoplastics (MNPs) are increasingly recognized as pervasive environmental contaminants with profound implications for ecosystems and human health. Their small size, compositional diversity, and occurrence across complex matrices—including water, soil, food, and biological samples—pose substantial analytical challenges. Conventional techniques such as vibrational spectroscopy, chromatographic analysis, and electron microscopy have yielded critical insights into MNP composition, morphology, and distribution; however, these methods often face limitations in sensitivity, throughput, and adaptability to real-world samples. Recent advances in nanotechnology have catalyzed the emergence of nanodevices—encompassing nanosensors, nanopore systems, integrated lab-on-a-chip platforms and nanostructured capture materials—that promise enhanced sensitivity, specificity, and the capacity for real-time, in situ detection. These innovations not only facilitate high-throughput analysis but also provide novel opportunities for integrated characterization of MNPs across diverse matrices. This review synthesizes the current state of nanodevice-based MNP detection, critically examining their principles, performance, and limitations relative to conventional approaches, and outlining the key needs for standardization, matrix-specific adaptation, and regulatory harmonization. Full article
(This article belongs to the Special Issue Smart Nanodevices for Therapy: Present and Future Perspectives)
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