Advances on Pharmaceutical Nanotechnology at the Interface with Biological Barriers

Dear Colleagues,

Pharmaceutical nanotechnologies, over the past twenty years, have shown great potential for drug delivery due to their unique biopharmaceutical properties. The first breakthrough applications were related to the intravenous administration of anticancer drugs-loaded liposomes, opening the possibility to target tumor parenchyma via the enhanced-permeability and retention effect. However, more recently, the development of nanocarriers starting from biomimetic materials and with more or less complex surface modifications has widened the possibilities of drug-loaded nanoparticles, allowing for administration via different administration routes, stimuli or environment responsive drug delivery, active targeting of organs or specific cells and multiple actions, as in the case of theranostics. Still, the behavior of such complex delivery systems at the interface with biological barriers and their mechanism of action as delivery or carrier systems is often not completely elucidated.

The aim of this Special Issue is to go deep inside these challenges offered by pharmaceutical nanotechnologies, presenting recent innovations in nanomaterials for drug delivery, including biodegradable, surface-modified, stimuli-responsive or targeted nanoparticles, liposomes, and micelles designed to cross and investigated for their interactions with biological interfaces when administered via nonparenteral administration routes. As the Guest Editors, we cordially invite you to contribute a research paper or comprehensive review on any aspect related to this topic.

Prof. Fabio Sonvico
Prof. Sara Nicoli
Guest Editors

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