Pharmaceutical Excipients for Oral Drug Delivery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (15 May 2021) | Viewed by 3951
Special Issue Editors
Interests: pharmaceutical excipients; oral drug delivery; direct compression; co-processing; 3D printed medicines for oral drug de-livery; development of novel high-performance excipients for drug formulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Excipients are often the main components of any pharmaceutical formulation, and are crucial for their safe and effective use. Pharmaceutical excipients perform multiple functions, such as fillers, lubricants, stabilizers, antioxidants, preservatives, solubility modulators, improving bioavailability and patient acceptance, etc. Over the last two decades, the development of pharmaceutical excipients has gained importance and has been rapidly growing due to their demand in areas such as formulations for new active molecules, solubility-enhancing excipients, emerging 3D personalized treatments, excipients presenting improved manufacturing properties, the evolution of regulatory requirements, or the development of formulations with fewer ingredients. To answer to all these needs, there are three types of excipients for which the development processes can vary significantly: modified excipients, co-processed excipients, and novel excipients. The most challenging task facing these three categories is the development of novel excipients which can be considered as new chemical entities (NCEs), and therefore requires a thorough characterization to demonstrate their safety.
This Special Issue aims to identify and review the latest advances in excipient development to overcome the abovementioned challenges in oral drug delivery systems. Attention will also be paid to the relevance of the excipient’s physicochemical properties–functionality relationship in order to ensure the reliable production and performance of dosage forms, especially for bio-sourced and modified excipients.
Dr. Noelia Sanchez-Ballester
Dr. Ian Soulairol
Guest Editors
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Keywords
- Pharmaceutical excipient
- Oral drug delivery
- Modified excipients
- Functionality
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