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Special Issue "Design and Application of Metal-Binding Proteins"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 October 2019

Special Issue Editor

Guest Editor
Prof. Aimin Liu

Department of Chemistry, The University of Texas at San Antonio, San Antonio, United States
Website | E-Mail
Interests: metalloproteins; protein engineering; protein evolution; transition metals; metals in biology

Special Issue Information

Dear Colleagues,

Metal-binding proteins are ubiquitously employed across all kingdoms of life to perform a remarkable array of critical functions. In metabolic pathways, the committed, irreversible, or key regulatory reaction steps are often mediated by metalloenzymes. Other than catalysis, Metal-binding proteins perform heavy metal accumulation, cellular sensing and signaling, gene regulation, transfer (e.g., electron, O2), and structural roles linked to protein-protein or protein-DNA interactions. Reaching a satisfying understanding of the mechanisms by which metals carry out these functions requires the coordinated application of many approaches and expertise from many disciplines. The knowledge gained has already been widely utilized to design metal-binding proteins and peptides for bioremediation, detoxification, biomedical imaging, biofuel, and synthesis of pharmaceuticals. One of the latest Nobel prizes in Chemistry was awarded last year to Dr. Frances H. Arnold “for the directed evolution of enzymes,” highlighting the pioneering work and accomplishments in the protein engineering field for creating new enzymes to manufacture everything that brings the most significant benefit to humankind. This major award was also a call to the scientific community for more attention and appreciation for protein design and applications. In this Special Issue, we invite investigators to contribute original research articles, as well as review articles that are related to the design and implementation of metal-binding proteins. We are particularly interested in but are not limited to, research that involves de novo protein design, directed evolution, rational design of metal-binding proteins, including using genetic code expansion approaches, for both mechanistic understandings and industrial or medical applications.

Prof. Aimin Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Metals in biology
  • Protein engineering
  • Protein design
  • Directed evolution
  • Metalloproteins
  • Metals in medicine
  • Metals in signaling
  • Protein structure-function relationships
  • Unnatural amino acid

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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