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Special Issue "Emerging Frontiers in Glycosaminoglycans and Mimetics"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 June 2019

Special Issue Editors

Guest Editor
Dr. Giangiacomo Torri

Carbohydrate Sciences Department, Ronzoni Institute, Milan, Italy
Website | E-Mail
Interests: heparin; LMWH; glycosaminoglycan; protein–carbohydrate interaction; glycol-split heparins; heparin mimetics; nanoparticles engineered with heparin; polysaccharides and derivatives; structure–activity relationship; oligosaccharide analysis; nuclear magnetic resonance/PCA; mass spectrometry
Guest Editor
Prof. Jawed Fareed

Loyola University Medical Center, Maywood, USA
Website | E-Mail
Interests: athophysiologic characterization of thrombotic and cardiovascular agents; development of new antithrombotic drugs; pharmacologic differentiation of low molecular weight heparins; development of heparinomimetic drugs; molecular modeling of thrombogenesis using simulated systems; development of animal models of thrombotic and ischemic disorders
Guest Editor
Prof. Job Harenberg

Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer Ufer 1-3 - D-68167 Mannheim, Germany
Website | E-Mail
Interests: heparin; glycosaminoglycans; anticoagulant activity; anticoagulant methods; protein interactions; biological activities; clinical applications

Special Issue Information

Dear Colleagues,

In the past 35 years, we have witnessed important developments in the knowledge of glycosaminoglycans (GAGs), among which the heparin and heparin like compounds have received the most attention. Researchers have clarified relevant scientific aspects and have led to evolutions in the clinical use of heparin, especially due to the introduction of various low-molecular weight heparins. Currently, the research is increasingly focusing on the pleiotropic clinical potentials of GAGs, such as their antitumoral, anti-metastatic, and antiviral activities. Attention is also given to the structural differentiation occurring between molecules extracted from different animal species and tissues, while the explanation of these differences is still delayed. Studies in the field of the biotechnological synthesis routes, GAG derivatives and mimetics, functionalized materials, and nanostructures are also under development.This initiative follows the collection of 21 articles published by Molecules in the Special Issue “Looking Forward to the Future of Heparin: New Sources, Developments and Applications” published on the anniversary of the heparin centenary.Given the interest raised by that Issue, it is considered appropriate to re-propose the initiative, inviting the researchers involved in this sector to participate, in particular exhorting those who participated in the Symposium of Glycosaminoglycans, held annually at the German–Italian Centre for European Excellence, Villa Vigoni, Menaggio, Lake Como, Italy.International expert groups are invited to contribute to this new initiative with actual and emerging topics of interest in the fields of chemistry, biochemistry, biology, pharmacology, regulatory rules, and clinical applications of heparin and other glycosaminoglycans. Both basic and applied aspects will be included in the collection.

Dr. Giangiacomo Torri
Prof. Jawed Fareed
Prof. Job Harenberg
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heparin
  • structure–function relationship
  • heparin-like molecules
  • heparinases and heparanase
  • pleiotropic biological effects
  • chemical and analytical methods
  • clinical application of heparin and related compounds

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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