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Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers

1
Division of Biomedical Engineering, Research Institute, National Defense Medical College, 3-2 Namiki, Tokorazawa, Saitama 359-8513, Japan
2
Department of Oral and Maxillofacial Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
3
Division of Environmental Medicine, Research Institute, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-1324, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Giangiacomo Torri, Jawed Fareed and Job Harenberg
Molecules 2019, 24(24), 4630; https://doi.org/10.3390/molecules24244630
Received: 18 November 2019 / Revised: 10 December 2019 / Accepted: 11 December 2019 / Published: 17 December 2019
(This article belongs to the Special Issue Emerging Frontiers in Glycosaminoglycans and Mimetics)
Heparinoid is the generic term that is used for heparin, heparan sulfate (HS), and heparin-like molecules of animal or plant origin and synthetic derivatives of sulfated polysaccharides. Various biological activities of heparin/HS are attributed to their specific interaction and regulation with various heparin-binding cytokines, antithrombin (AT), and extracellular matrix (ECM) biomolecules. Specific domains with distinct saccharide sequences in heparin/HS mediate these interactions are mediated and require different highly sulfated saccharide sequences with different combinations of sulfated groups. Multivalent and cluster effects of the specific sulfated sequences in heparinoids are also important factors that control their interactions and biological activities. This review provides an overview of heparinoid-based biomaterials that offer novel means of engineering of various heparin-binding cytokine-delivery systems for biomedical applications and it focuses on our original studies on non-anticoagulant heparin-carrying polystyrene (NAC-HCPS) and polyelectrolyte complex-nano/microparticles (N/MPs), in addition to heparin-coating devices. View Full-Text
Keywords: glycosaminoglycan; heparinoid; heparinoid-based biomaterials; heparin-binding cytokines; heparinoid-carrying polystyrene; polyelectrolyte complexes glycosaminoglycan; heparinoid; heparinoid-based biomaterials; heparin-binding cytokines; heparinoid-carrying polystyrene; polyelectrolyte complexes
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Ishihara, M.; Nakamura, S.; Sato, Y.; Takayama, T.; Fukuda, K.; Fujita, M.; Murakami, K.; Yokoe, H. Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers. Molecules 2019, 24, 4630.

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