E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Plant Bioactives in Preventing Chronic Diseases"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2019

Special Issue Editors

Guest Editor
Prof. Chiara Tonelli

Department of BioSciences, Università degli Studi di Milano, Milan, Italy
Website | E-Mail
Interests: polyphenols; anthocyanins; functional foods; nutrigenomics; water stress
Guest Editor
Prof. Katia Petroni

Department of BioSciences, Università degli Studi di Milano, Milan, Italy
Website | E-Mail
Interests: flavonoids; anthocyanins; nutrigenomics; cardioprotection; obesity

Special Issue Information

Dear Colleagues,

The alarming increase of chronic diseases has become a prominent problem for many industrialized countries and emerging economies with both societal and economic consequences. Among non-pharmacological interventions, nutritional recommendations represent a feasible means of developing preventive strategies against chronic diseases. A number of studies suggest that plant bioactives have protective effects against cardiovascular disease, obesity, cancer and neurodegenerative diseases. However, for many of them a clear understanding of the contribution or the exact mechanism of action as health-protecting components of our daily diet is still incomplete.

This Special Issue aims to attract and review the latest research concerning plant bioactives and the prevention of chronic diseases, focusing on the biochemical, molecular and health-promoting effects.

Prof. Chiara Tonelli
Prof. Katia Petroni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactive phytochemicals
  • Polyphenols
  • Carotenoids
  • Glucosinolates
  • Nutraceuticals
  • Functional foods
  • Chronic diseases
  • Cardiovascular diseases
  • Obesity
  • Cancer prevention
  • Neurodegenerative diseases

Related Special Issue

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Research

Open AccessArticle Aloin Inhibits Müller Cells Swelling in a Rat Model of Thioacetamide-Induced Hepatic Retinopathy
Molecules 2018, 23(11), 2806; https://doi.org/10.3390/molecules23112806
Received: 28 September 2018 / Revised: 19 October 2018 / Accepted: 29 October 2018 / Published: 29 October 2018
PDF Full-text (2589 KB) | HTML Full-text | XML Full-text
Abstract
Swelling of retinal Müller cells is implicated in retinal edema and neuronal degeneration. Müller cell swelling is observed in patients with liver failure and is referred to as hepatic retinopathy. In the present study, we evaluated the effects of aloin, an anthraquinone-C-glycoside present [...] Read more.
Swelling of retinal Müller cells is implicated in retinal edema and neuronal degeneration. Müller cell swelling is observed in patients with liver failure and is referred to as hepatic retinopathy. In the present study, we evaluated the effects of aloin, an anthraquinone-C-glycoside present in various Aloe species, on Müller cell dysfunction in a rat model of thioacetamide (TAA)-induced hepatic retinopathy. Experimental hepatic retinopathy was induced by three injections of TAA (200 mg/kg/day, intraperitoneal injection) for 3 days in rats. After the last injection of TAA, aloin (50 and 100 mg/kg) was orally gavaged for 5 days. The effects of aloin on the liver injury, serum ammonia levels, Müller cell swelling, glial fibrillary acidic protein (GFAP) expression, and gene expression of Kir4.1 and aquaporin-4 were examined. TAA-injected rats exhibited liver failure and hyperammonemia. In the TAA-injected rats, Müller cell bodies were highly enlarged, and GFAP, an indicator of retinal stress, was highly expressed in the retinas, indicating a predominant Müller cell gliosis. However, administration of aloin suppressed liver injury as well as Müller cell swelling through the normalization of Kir4.1 and aquaporin-4 channels, which play a key role in potassium and water transport in Müller cells. These results indicate that aloin may be helpful to protect retinal injury associated with liver failure. Full article
(This article belongs to the Special Issue Plant Bioactives in Preventing Chronic Diseases)
Figures

Figure 1

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top