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Enoxacin and Epigallocatechin Gallate (EGCG) Act Synergistically to Inhibit the Growth of Cervical Cancer Cells in Culture

1
Department of Biology, Belmont University; 1900 Belmont Boulevard, Nashville, TN 37212, USA
2
Department of Pharmaceutical Sciences, College of Pharmacy, Belmont University; 1900 Belmont Boulevard, Nashville, TN 37212, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Chiara Tonelli and Katia Petroni
Molecules 2019, 24(8), 1580; https://doi.org/10.3390/molecules24081580
Received: 8 February 2019 / Revised: 11 April 2019 / Accepted: 18 April 2019 / Published: 22 April 2019
(This article belongs to the Special Issue Plant Bioactives in Preventing Chronic Diseases)
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Abstract

Cervical cancer is a major cause of death in females worldwide. While survival rates have historically improved, there remains a continuous need to identify novel molecules that are effective against this disease. Here, we show that enoxacin, a drug most commonly used to treat a broad array of bacterial infections, is able to inhibit growth of the cervical cancer cells. Furthermore, our data show that epigallocatechin gallate (EGCG), a plant bioactive compound abundant in green tea, and known for its antioxidant effects, similarly functions as an antiproliferative agent. Most importantly, we provide evidence that EGCG functions synergistically against cancer cell proliferation in combined treatment with enoxacin. These data collectively suggest that enoxacin and EGCG may be useful treatment options for cases of cervical cancer. View Full-Text
Keywords: oncology; cancer; apoptosis; cell cycle; HeLa; enoxacin; EGCG oncology; cancer; apoptosis; cell cycle; HeLa; enoxacin; EGCG
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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McDonnell, A.M.; Pyles, H.M.; Diaz-Cruz, E.S.; Barton, C.E. Enoxacin and Epigallocatechin Gallate (EGCG) Act Synergistically to Inhibit the Growth of Cervical Cancer Cells in Culture. Molecules 2019, 24, 1580.

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