Catalytic Cascade Reactions

Dear Colleagues,

In recent years, the drive to maximize the brevity of synthetic schemes came to the forefront of organic synthesis. The emergence of various cascade reactions, also referrred to as domino or tandem reactions, brought about major breakthroughs in this field. Cascade reactions create multiple carbon–carbon bonds in a single synthetic operation and rapidly achieve a significant increase in the molecular complexity. Cascade reactions that are performed under catalytic conditions are the most desirable from the standpoint of overall atom economy.

Strategic applications of cascade reactions with diverse mechanistic foundations (reactions with ionic, radical or metal-containing intermediates) in total synthesis delivered impressively short and efficient routes to highly complex organic structures.

The aims of this Special Issue is to highlight recent advances in the design, development and applications of catalytic cascade reactions to organic synthesis. Of special interest are catalytic asymmetric reactions, as well as protocols that could trigger stereo-divergent or regio-divergent pathways by a change in the features of the catalytic system.

Prof. Dr. Helena C. Malinakova
Guest Editor

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