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Chemical Composition, Pharmacological and Therapeutic Activity of Plant Extracts

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 643

Special Issue Editors


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Guest Editor
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
Interests: plant extracts; oxidative stress; cardiovascular pathophysiology; psoriasis; PCOS; pituitary–gonadal axis; histology; immune-mediated diseases

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Guest Editor
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
Interests: phytotherapy; pharmaceutical technology; wound healing; plant-based formulation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
Interests: oxidative stress; PCOS; antioxidants; cardiometabolic risk; metabolic syndrome; hormone disbalance; phytotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We warmly invite you to submit your work to this Special Issue, which focuses on the latest developments in the chemical composition, pharmacological activity, and therapeutic potential of plant extracts.

Natural compounds have played a vital role in traditional medicine for centuries. Owing to their chemical diversity and ability to act on multiple molecular pathways, they represent a valuable source of therapeutic agents for complex, multifactorial diseases such as inflammatory, cardiovascular, metabolic, endocrine, and neurodegenerative disorders. With well-established antioxidant, anti-inflammatory, immunomodulatory, and antimicrobial properties, plant-derived bioactive molecules continue to attract scientific interest as safer and more affordable alternatives to conventional therapies.

This Special Issue aims to highlight recent advances in the chemical characterization, pharmacological properties, and therapeutic applications of plant extracts. We welcome original research and review articles addressing a wide range of topics, including phytochemical profiling, mechanisms of pharmacological activity, and in silico, in vitro, and in vivo experimental studies. By bringing together studies on the composition, bioactivity, and therapeutic use of plant extracts, this Special Issue seeks to provide an integrative perspective and foster new insights into the development of plant-based therapeutic strategies.

Dr. Jasmina Sretenovic
Dr. Jovana Bradic
Dr. Jovana Joksimovic Jovic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • natural product chemistry
  • in silico, in vitro, and in vivo studies
  • acute and chronic inflammation
  • cardiometabolic disorders
  • endocrine disorders
  • neurodegenerative disorders

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Published Papers (1 paper)

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Research

17 pages, 1804 KB  
Article
Multi-Target Anti-Psoriatic Effects of Melissa officinalis: Phytochemical, Redox, Immunological, and Histological Evidence from an In Vivo Study
by Branislava Daskalovic, Vladimir Jakovljevic, Sergej Bolevic, Marijana Andjic, Jovana Bradic, Aleksadar Kocovic, Nevena Lazarevic, Vanja Tadic, Ana Zugic, Milos Krivokapic, Nenad Stankovic, Svetlana Trifunovic and Jasmina Sretenovic
Molecules 2026, 31(9), 1471; https://doi.org/10.3390/molecules31091471 - 29 Apr 2026
Viewed by 297
Abstract
Psoriasis is a chronic inflammatory skin disease linked to immune dysregulation and oxidative stress. Due to the limitations and side effects of conventional therapies, natural compounds are gaining increasing attention. The aim of this study was to evaluate the therapeutic potential of Melissa [...] Read more.
Psoriasis is a chronic inflammatory skin disease linked to immune dysregulation and oxidative stress. Due to the limitations and side effects of conventional therapies, natural compounds are gaining increasing attention. The aim of this study was to evaluate the therapeutic potential of Melissa officinalis extract in psoriasis. HPLC analysis was used to characterize the extract, while its antioxidant activity was assessed by DPPH, ABTS, and FRAP assays. An in vivo study was conducted on 18 male Wistar albino rats divided into control (CTRL), psoriasis (PSORI), and psoriasis treated with M. officinalis (PSORI+MO) groups. Psoriasis was induced by daily topical application of 5% imiquimod cream on the shaved back skin of rats for seven constitutive days. The PSORI+MO group received M. officinalis extract orally at a dose of 200 mg/kg during seven days. Redox and inflammatory cytokine analysis were performed. Isolated skin was fixed and stained with H/E and immunohistochemical staining. Morphometric and histological analyses revealed reduced inflammation, keratinocyte proliferation, and epidermal thickness. Systemic and tissue redox status showed decreased oxidative stress biomarkers and enhanced antioxidant defense. Inflammatory cytokines (IL-17A, IL-22, IL-23, IL-1β, and IL-6) were significantly reduced. Our findings suggest that Melissa officinalis extract exerts anti-psoriatic effects through antioxidant, anti-inflammatory, and antiproliferative mechanisms. Full article
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