Role of Oxidative Stress and Antioxidants in Women’s Reproductive and Sexual Health
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Sex, Gender and Hormone Based Medicine".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 587
Special Issue Editor
Interests: oxidative stress; PCOS; antioxidants; cardiometabolic risk; metabolic syndrome; hormone disbalance; phytotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Some physiological processes depend on the formation of reactive oxygen species (ROS), which enables and ensures that the cells and tissues are operating in a homeostatic environment. However, oxidative stress occurs due to increased levels of ROS and/or a weakened antioxidative potential. ROS are involved in a plethora of biological effects, participating in the pathogenesis of an increasing number of diseases, thus identifying the biomarkers of oxidative stress could be of importance in prevention as well as therapy of various diseases. Moreover, it is known that oxidative stress levels vary between genders and depend on hormone-related alterations. Reproductive and sexual health are dependent on global redox homeostasis, but research data on the role of antioxidants in the prevention and treatment of oxidative stress-related pathologies in women are conflicting. Starting with reproductive endocrine disorders such as polycystic ovary syndrome (PCOS), progressing to pregnancy-related disorders such as preeclampsia and gestational diabetes mellitus (GDM), and ending with the loss of estrogen-protective roles in menopause, women’s organisms are highly vulnerable to oxidative stress. Accordingly, many antioxidative molecules have been investigated, and their beneficial effects have been proven in many translational, preclinical, and clinical studies. Although concerns about their safety in the pre-gestational and gestational period remain elusive, various nutraceutical and pharmaceutical interventions have been carried out to ameliorate oxidative stress in women. Potential topics include but are not limited to the role of oxidative stress and antioxidants in PCOS, endometriosis, preeclampsia, GDM, intrauterine growth retardation, preterm birth, women's sexual dysfunction, inflammatory processes of women’s genital organs, and similar entities. In addition to the basic science to clinical translational work that is fundamental to uncovering the complex relationship between oxidative stress and reproductive pathophysiology, this Special Issue highlights the importance of recognizing the known and potentially novel biomarkers of oxidative stress in different pathologies related to reproductive and sexual health.
Original and review articles (including experiments on animals or human studies) addressing these topics are invited for this Special Issue, which is focused on the determination of oxidative stress biomarkers in reproductive and sexual disorders in women as well as the role of antioxidants in mitigating pathophysiological disturbances and exhibiting preventive or therapeutic potential.
Dr. Jovana Joksimovic Jovic
Guest Editor
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Keywords
- oxidative stress
- antioxidants
- women
- PCOS
- endometriosis
- gestational diabetes mellitus
- preeclampsia
- sexual dysfunction
- preterm birth
- menopause
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