Targeted Nanomedicine Design
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 8708
Special Issue Editors
Interests: vascular nanomedicine; targeting delivery; atherosclerosis
Interests: biomimetic nanomaterials; immunotherapy; cell-based drug delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since the first FDA’s approval of Doxil in 1995, less than a hundred nanomedicines in total (according to the incomplete statistics of nanomedicines commercially used in the clinic) have come onto the market in the past almost three decades. The process of inventing a nanomedicine usually takes years or even a decade to complete, and is full of a variety of challenges. The biggest obstacle for a nanoparticle to become a real nanomedicine is the lack of precise control of a nanoparticle’s in vivo fate, including subcellular distribution, cellular metabolism, and in vivo pharmacokinetics. Mounting evidence has demonstrated that the nanoparticle’s in vivo fate highly depends on the physicochemical properties of nanoparticles, including shape, size, and surface charge as well as the nature of nanomaterials, etc. With the advances in nanotechnology, engineering technologies, and precise bioimaging techniques, etc., the ability to control the physicochemical characteristics of designed nanoparticles has greatly enhanced. A growing number of studies have suggested that their designed nanoparticles could be controlled precisely, thus exhibiting optimal in vivo performance (efficacy and safety). Among them, biomimetic nanoparticles (derived from cells, bacteria, and cellular organoids) are attracting much attention. In addition, micro/nanorobots represent an innovative approach to achieving precise drug delivery and perform multiple tasks that some conventional drug delivery systems cannot fulfill.
In this Special Issue “Targeted Nanomedicine Design”, we highly welcome all researchers in the fields of nanotechnology, biomedical engineering, biomacromolecules, and nanomedicines to kindly present their latest research findings related to this topic to guide newer scientists (students, trainees) and share some valuable experiences among researchers.
Dr. Hongliang He
Dr. Lisha Liu
Dr. Ling Mei
Guest Editors
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Keywords
- nanomedicine design
- subcellular targeting
- precise design
- sensitive nanomedicine
- micro/nanorobots
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