Innovative Therapeutic Delivery Strategies for Brain Tumors: Overcoming Barriers and Modulating the Tumor Microenvironment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 41

Special Issue Editors


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Guest Editor
Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan
Interests: nanotechnology; biosensors; virus-like particles applications; fluorescent RNA/RNAi/drug delivery systems

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Guest Editor
Center for Childhood Cancer, Nationwide Children’s Hospital, Columbus, OH 43205, USA
Interests: brain tumor; microRNA; systemic lupus erythematosus; bioinformatics; immunity and autoimmunity

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Guest Editor
Graduate School of Medicine, Sendai, Japan
Interests: brain tumor; DIPG; telomere damage; DNA damage; radiotherapy
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Interests: drug delivery; cancer immunotherapy; cardiovascular disease; pharmaceutical science
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Special Issue Information

Dear Colleagues,

Brain tumors remain one of the most challenging malignancies due to their complex tumor microenvironment, the presence of the blood–brain barrier, and their ability to evade immune responses. Advanced therapeutic delivery systems, including drug formulations, gene therapy, and immunotherapy, have emerged as promising strategies for enhancing treatment efficacy. This Special Issue aims to gather cutting-edge research on innovative delivery methods and their effects on the tumor microenvironment, immune responses, and surrounding tissues. We welcome the submission of original research and review articles covering novel drug delivery technologies, their mechanisms of interaction with brain tumor microenvironments, and translational and clinical findings. This collection will provide valuable insights for researchers and clinicians working toward improved therapeutic strategies for primary and metastatic brain tumors.

Dr. Hao-Han Pang
Dr. Zhuang Wang
Dr. Banlanjo A. Umaru
Dr. Lisha Liu
Guest Editors

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Keywords

  • brain tumors
  • drug delivery
  • blood–brain barrier
  • immunotherapy
  • gene therapy
  • tumor microenvironment
  • nanoparticles

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This special issue is now open for submission.
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