Advances in Pharmacokinetic Drug–Drug Interactions

Dear Colleagues,

The investigation of drug–drug interactions is essential for drug discovery and development. The important mechanisms for pharmacokinetic drug–drug interactions include the inhibition or induction of drug metabolism and transporters. It is essential to evaluate absorption, distribution, metabolism, excretion (ADME) and pharmacokinetic interactions of novel molecules, and investigational drugs for effective drug development. Remarkable progress has been made over the past few decades in ADME and DMPK tools that can promote the development of novel therapies and advances in understanding the effects of diseases on PK and minimize the potential of drug–drug interactions and reduce attrition rates in drug development. This Special Issue welcomes the submission of original research and/or review articles on drug discovery and development related to the advancements of in vitro, in vivo, and ex vivo ADME and DMPK, in vitro to in vivo correlation and extrapolation (IVIVC/E), biotransformation, drug–drug interactions, and pharmacokinetic interactions related to drug-metabolizing enzymes and drug transporters. This Special Issue will promote a quantitative and mechanistic understanding of the pharmacokinetic interactions of novel drug candidates in biological systems. 

Dr. Guru Raghavendra Valicherla
Dr. Jiaur Rahaman Gayen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.