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Special Issue "Phytochemistry, Biological Activities and Applications of the Piperaceae"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2019

Special Issue Editors

Guest Editor
Prof. Dr. William N. Setzer

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Website | E-Mail
Interests: phytochemistry; essential oils; natural product drug discovery; molecular modeling; chemical ecology
Assistant Guest Editor
Prof. Joyce Kelly R. Da Silva

Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Pará, Belém, Pará, Brazil
Website | E-Mail
Interests: natural products drug discovery; essential oils; phytochemistry; chemical ecology; molecular plant biology

Special Issue Information

Dear colleague,

The Piperaceae is a large family with as many as 50 genera and nearly 4000 species. Members of the Piperaceae, especially Peperomia and Piper species, are rich sources of biologically active phytochemicals with a high structural diversity. In this special issue, we invite reviews and research articles that identify the chemical components, demonstrate the biological activities, and illustrate recent advances and discoveries in the Piperaceae.

Prof. William N. Setzer
Guest Editor

Prof. Joyce Kelly R. da Silva
Assistant Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chemical composition
  • pharmacology
  • chemical ecology
  • biological assays

Published Papers (1 paper)

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Open AccessReview
Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications
Molecules 2019, 24(7), 1364; https://doi.org/10.3390/molecules24071364
Received: 13 March 2019 / Revised: 25 March 2019 / Accepted: 3 April 2019 / Published: 7 April 2019
PDF Full-text (1030 KB) | HTML Full-text | XML Full-text
Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. [...] Read more.
Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed. Full article

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