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Pharmacological Activities of Medicinal Plants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2196

Special Issue Editors


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Guest Editor
Laboratório de Química de Produtos Naturais, Universidade do Estado do Pará, Belém 66095-015, PA, Brazil
Interests: volaliles; essential oil; in vivo studies; pharmacology; pain; inflammation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Faculty of Biotechnology, Federal University of Pará, Belém 66075-110, Brazil
Interests: volatiles; essential oil; in vitro studies; plant interactions; microbiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Medicinal plants are reported worldwide to treat various pathological conditions that affect human health. However, we need to validate these species' potential pharmacological and toxicological properties, analyze the chemical profile, and verify the action of these molecules in chemical and biological tests.

This Special Issue, titled "Pharmacological activities of medicinal plants", aims to present studies that report the chemical characterization of botanical species and their pharmacological activity and isolation of molecules with bioactive properties. Moreover, studies proving that the medical plant lacks biological propriety are welcome.

Dr. Pablo Luis B. Figueiredo
Prof. Dr. Joyce Kelly R. Da Silva
Guest Editors

Manuscript Submission Information

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Keywords

  • natural products
  • in vivo models
  • in vivo assay
  • pharmacological activities
  • pain
  • inflammation
  • enzyme inhibitory activity

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Published Papers (1 paper)

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Research

18 pages, 6587 KiB  
Article
Evaluation of Bioactive Compounds, Antioxidant Capacity, and Anti-Inflammatory Effects of Lipophilic and Hydrophilic Extracts of the Pericarp of Passiflora tripartita var. mollissima at Two Stages of Ripening
by Hugo Jesús Justil-Guerrero, Jorge Luis Arroyo-Acevedo, Juan Pedro Rojas-Armas, Carlos Orlando García-Bustamante, Miriam Palomino-Pacheco, Robert Dante Almonacid-Román and James Willan Calva Torres
Molecules 2024, 29(20), 4964; https://doi.org/10.3390/molecules29204964 - 21 Oct 2024
Cited by 1 | Viewed by 1622
Abstract
Chronic disease inflammation requires safe complementary treatments. The pericarp of Passiflora tripartita var. mollissima (PTM) contains potential anti-inflammatory metabolites. This study aimed to evaluate the bioactive components, antioxidant capacity, and anti-inflammatory effects of PTM extracts at two ripening stages. The bioactive compounds in [...] Read more.
Chronic disease inflammation requires safe complementary treatments. The pericarp of Passiflora tripartita var. mollissima (PTM) contains potential anti-inflammatory metabolites. This study aimed to evaluate the bioactive components, antioxidant capacity, and anti-inflammatory effects of PTM extracts at two ripening stages. The bioactive compounds in the hydrophilic and lipophilic extracts of mature and green pericarps were identified by GC-MS and UV–VIS, while the antioxidant capacity was measured by free radical reduction. Anti-inflammatory effects were tested using a rat paw edema model with carrageenan-induced edema, indomethacin, or PTM extracts (100, 250, and 500 mg/kg). The effect of mature hydrophilic extract was further evaluated in an air pouch model, where rats received the placebo, carrageenan, indomethacin, or the extract (500 and 1000 mg/kg). Leukocytes, cytokines, and markers of oxidative stress were evaluated. The results showed the presence of organic compounds, total phenols, and flavonoids. The mature hydrophilic extract exhibited the highest antioxidant activity. At 500 mg/kg, it reduced edema, leukocyte migration, and levels of IL-1β, IL-6, and TNF-α while managing oxidative stress and preventing histological damage. In conclusion, PTM contains bioactive compounds with potential pharmacological properties. The hydrophilic extract of the mature pericarp, at a dose of 500 mg/kg, exhibits an enhanced antioxidant and anti-inflammatory effect. Full article
(This article belongs to the Special Issue Pharmacological Activities of Medicinal Plants)
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