Special Issue "Neuroprotective Agents to Treat Dementias"
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 9653
Interests: drug discovery; synthesis and structure–activity relationships of biologically active compounds; multitarget agents; hybrid compounds; kinase inhibitors; pro-autophagic molecules; neuroprotective agents; antioxidant molecules; medicinal chemistry
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Alzheimer’s disease (AD) is a progressive age-dependent and multi-factorial neurodegenerative pathology that leads to cognitive dysfunction and continues to have a significant impact on society as a whole. Given that the main drawback of AD therapy remains to be its limited effectiveness, the search for new potential drugs is heavily pursued. Several pathways are involved in AD’s etio-pathology, both in peripheral and central human districts that include aberrant lipid metabolism, oxidative stress, mitochondrial impairment, neuroinflammatory processes, impairment of autophagic flux, and blood–brain barrier (BBB) disruption.
This Special Issue “Neuroprotective Agents to Treat Dementias” welcomes the submission of review and research articles related to the design and synthesis of new molecules that could provide an innovative approach for the treatment of AD or other forms of dementia, including mechanisms and pharmacological characterization. Moreover, full research articles and/or reviews covering drugs repurposing approaches in neurodegenerative diseases are welcome.
Prof. Dr. Simona Rapposelli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- autophagy inducers
- antioxidant agents
- anti-ageing agents
- multitarget drugs
- metabolic disorders
- NrF2-ARE pathway
- oxidative stress
- mitochondrial dysfunction
- metal chelating agents
- Alzheimer’s disease
- Repurposing drugs