Next Article in Journal
Towards Rational Biosurfactant Design—Predicting Solubilization in Rhamnolipid Solutions
Previous Article in Journal
Microwave-Assisted Synthesis, Structural Characterization and Assessment of the Antibacterial Activity of Some New Aminopyridine, Pyrrolidine, Piperidine and Morpholine Acetamides
Previous Article in Special Issue
Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening
Review

The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging

1
Keck Graduate Institute, The Claremont Colleges, Claremont, CA 91711, USA
2
Pitzer College, The Claremont Colleges, Claremont, CA 91711, USA
3
Claremont McKenna College, The Claremont Colleges, Claremont, CA 91711, USA
4
Department of Bioengineering, University of California, Berkeley, CA 94720, USA
*
Author to whom correspondence should be addressed.
Academic Editor: R. Michael van Dam
Molecules 2021, 26(3), 535; https://doi.org/10.3390/molecules26030535
Received: 30 October 2020 / Revised: 4 January 2021 / Accepted: 14 January 2021 / Published: 20 January 2021
(This article belongs to the Special Issue Microfluidic Tools for High-Throughput Screening)
As the fields of aging and neurological disease expand to liquid biopsies, there is a need to identify informative biomarkers for the diagnosis of neurodegeneration and other age-related disorders such as cancers. A means of high-throughput screening of biomolecules relevant to aging can facilitate this discovery in complex biofluids, such as blood. Exosomes, the smallest of extracellular vesicles, are found in many biofluids and, in recent years, have been found to be excellent candidates as liquid biopsy biomarkers due to their participation in intercellular communication and various pathologies such as cancer metastasis. Recently, exosomes have emerged as novel biomarkers for age-related diseases. Hence, the study of exosomes, their protein and genetic cargo can serve as early biomarkers for age-associated pathologies, especially neurodegenerative diseases. However, a disadvantage of exosome studies includes a lack in standardization of isolating, detecting, and profiling exosomes for downstream analysis. In this review, we will address current techniques for high-throughput isolation and detection of exosomes through various microfluidic and biosensing strategies and how they may be adapted for the detection of biomarkers of age-associated disorders. View Full-Text
Keywords: exosomes; aging; microfluidics exosomes; aging; microfluidics
Show Figures

Figure 1

MDPI and ACS Style

DeCastro, J.; Littig, J.; Chou, P.P.; Mack-Onyeike, J.; Srinivasan, A.; Conboy, M.J.; Conboy, I.M.; Aran, K. The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging. Molecules 2021, 26, 535. https://doi.org/10.3390/molecules26030535

AMA Style

DeCastro J, Littig J, Chou PP, Mack-Onyeike J, Srinivasan A, Conboy MJ, Conboy IM, Aran K. The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging. Molecules. 2021; 26(3):535. https://doi.org/10.3390/molecules26030535

Chicago/Turabian Style

DeCastro, Jonalyn, Joshua Littig, Peichi P. Chou, Jada Mack-Onyeike, Amrita Srinivasan, Michael J. Conboy, Irina M. Conboy, and Kiana Aran. 2021. "The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging" Molecules 26, no. 3: 535. https://doi.org/10.3390/molecules26030535

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop