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Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging

Keck Graduate Institute, The Claremont Colleges, Claremont, CA 91711, USA
Pitzer College, The Claremont Colleges, Claremont, CA 91711, USA
Claremont McKenna College, The Claremont Colleges, Claremont, CA 91711, USA
Department of Bioengineering, University of California, Berkeley, CA 94720, USA
Author to whom correspondence should be addressed.
Academic Editor: R. Michael van Dam
Molecules 2021, 26(3), 535;
Received: 30 October 2020 / Revised: 4 January 2021 / Accepted: 14 January 2021 / Published: 20 January 2021
(This article belongs to the Special Issue Microfluidic Tools for High-Throughput Screening)
As the fields of aging and neurological disease expand to liquid biopsies, there is a need to identify informative biomarkers for the diagnosis of neurodegeneration and other age-related disorders such as cancers. A means of high-throughput screening of biomolecules relevant to aging can facilitate this discovery in complex biofluids, such as blood. Exosomes, the smallest of extracellular vesicles, are found in many biofluids and, in recent years, have been found to be excellent candidates as liquid biopsy biomarkers due to their participation in intercellular communication and various pathologies such as cancer metastasis. Recently, exosomes have emerged as novel biomarkers for age-related diseases. Hence, the study of exosomes, their protein and genetic cargo can serve as early biomarkers for age-associated pathologies, especially neurodegenerative diseases. However, a disadvantage of exosome studies includes a lack in standardization of isolating, detecting, and profiling exosomes for downstream analysis. In this review, we will address current techniques for high-throughput isolation and detection of exosomes through various microfluidic and biosensing strategies and how they may be adapted for the detection of biomarkers of age-associated disorders. View Full-Text
Keywords: exosomes; aging; microfluidics exosomes; aging; microfluidics
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MDPI and ACS Style

DeCastro, J.; Littig, J.; Chou, P.P.; Mack-Onyeike, J.; Srinivasan, A.; Conboy, M.J.; Conboy, I.M.; Aran, K. The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging. Molecules 2021, 26, 535.

AMA Style

DeCastro J, Littig J, Chou PP, Mack-Onyeike J, Srinivasan A, Conboy MJ, Conboy IM, Aran K. The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging. Molecules. 2021; 26(3):535.

Chicago/Turabian Style

DeCastro, Jonalyn, Joshua Littig, Peichi P. Chou, Jada Mack-Onyeike, Amrita Srinivasan, Michael J. Conboy, Irina M. Conboy, and Kiana Aran. 2021. "The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging" Molecules 26, no. 3: 535.

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