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Open AccessReview

Microfluidics in Haemostasis: A Review

1
School of Biological and Health Sciences, Technological University Dublin (TU Dublin) - City Campus, Kevin Street, Dublin D08 NF82, Ireland
2
engCORE, Faculty of Engineering, Institute of Technology Carlow, Kilkenny Road, Carlow R93 V960, Ireland
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(4), 833; https://doi.org/10.3390/molecules25040833
Received: 28 January 2020 / Revised: 11 February 2020 / Accepted: 12 February 2020 / Published: 14 February 2020
(This article belongs to the Special Issue Microfluidic Tools for High-Throughput Screening)
Haemostatic disorders are both complex and costly in relation to both their treatment and subsequent management. As leading causes of mortality worldwide, there is an ever-increasing drive to improve the diagnosis and prevention of haemostatic disorders. The field of microfluidic and Lab on a Chip (LOC) technologies is rapidly advancing and the important role of miniaturised diagnostics is becoming more evident in the healthcare system, with particular importance in near patient testing (NPT) and point of care (POC) settings. Microfluidic technologies present innovative solutions to diagnostic and clinical challenges which have the knock-on effect of improving health care and quality of life. In this review, both advanced microfluidic devices (R&D) and commercially available devices for the diagnosis and monitoring of haemostasis-related disorders and antithrombotic therapies, respectively, are discussed. Innovative design specifications, fabrication techniques, and modes of detection in addition to the materials used in developing micro-channels are reviewed in the context of application to the field of haemostasis. View Full-Text
Keywords: coagulation; haemostasis; LOC; MEMS; microfluidics; POC coagulation; haemostasis; LOC; MEMS; microfluidics; POC
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MDPI and ACS Style

Jigar Panchal, H.; Kent, N.J.; Knox, A.J.S.; Harris, L.F. Microfluidics in Haemostasis: A Review. Molecules 2020, 25, 833.

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