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The Medicinal Value of Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 July 2025) | Viewed by 7934

Special Issue Editor


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Guest Editor
Department of Biology and Biotechnology, School of Agriculture of the Polytechnic Institute of Bragança (ESA-IPB), Campus de Santa Apolónia, 5301-854 Bragança, Portugal
Interests: microbiology; food microbiology; food safety; healing; phenolic compounds; therapeutic properties; anti-inflammatory
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Special Issue Information

Dear Colleagues,

Over the past few decades, several FDA-approved drugs, developed from natural products, have made their way to clinical use. Indeed, many animals, microorganisms, and plants produce chemical compounds that have therapeutic properties. Additionally, advances in technology have made it easier to identify and isolate active compounds from natural matrices. Over the years, naturally available bioactive compounds have been a source of inspiration for the development of novel drugs, fostering modern pharmacology and toxicology.

The objective of the Special Issue, entitled “The Medicinal Value of Natural Products,” is to provide a comprehensive overview of current scientific research on natural products and their potential applications for human health. We invite authors to submit full papers, short communications, and review articles on various topics related to natural products, such as physiologically active compounds sourced from both terrestrial and marine plants; secondary metabolites produced by microorganisms (including antibiotics and mycotoxins); novel compound isolation, biochemical studies, and structure elucidation; the pharmacology of naturally occurring compounds; and the development of new detection and quantification methods. Furthermore, we also welcome articles that utilize bioinformatic tools.

Prof. Dr. Leticia M. Estevinho
Guest Editor

Manuscript Submission Information

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Keywords

  • natural products
  • antioxidants
  • antimicrobial properties
  • drug discovery
  • therapeutics
  • anti-neoplastic
  • pharmacognosy

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Published Papers (2 papers)

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Research

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16 pages, 2662 KB  
Article
Notoginsenoside R1, a Metabolite from Panax notoginseng, Prevents Paclitaxel-Induced Peripheral Neuropathic Pain in Mice
by Muneerah Al-Musailem, Willias Masocha and Altaf Al-Romaiyan
Molecules 2025, 30(17), 3613; https://doi.org/10.3390/molecules30173613 - 4 Sep 2025
Viewed by 1013
Abstract
Development of paclitaxel-induced neuropathic pain (PINP) during chemotherapy may lead to paclitaxel discontinuation, potentially compromising effective anticancer therapy. PINP can manifest as allodynia. One recently discovered key factor in paclitaxel-induced mechanical allodynia (PIMA) pathogenesis is the elevated activity of monoacylglycerol lipase (MAGL), an [...] Read more.
Development of paclitaxel-induced neuropathic pain (PINP) during chemotherapy may lead to paclitaxel discontinuation, potentially compromising effective anticancer therapy. PINP can manifest as allodynia. One recently discovered key factor in paclitaxel-induced mechanical allodynia (PIMA) pathogenesis is the elevated activity of monoacylglycerol lipase (MAGL), an enzyme that metabolizes the endocannabinoid 2-arachidonoylglycerol (2-AG). Thus, inhibiting MAGL serves as a potential analgesic target. Notoginsenoside R1 (NGR1), a metabolite of Panax notoginseng, has shown promise in reducing oxidative stress and neuronal apoptosis in nerve injury models. However, its effects on PIMA and MAGL activity have not yet been explored. This study is a proof-of-concept preclinical study investigating the antiallodynic effects of NGR1 on PIMA in female BALB/c mice and also examining its effect on MAGL activity. The effect of treatment of mice with NGR1 intraperitoneally on the development of PIMA was evaluated. Molecular docking using CB-Dock2 compared the binding energies to MAGL of NGR1 and pristimerin, a triterpene MAGL inhibitor. The effects of NGR1 on human recombinant MAGL activity, as well as the MAGL activity in mice paw skin tissues, were assessed using MAGL inhibitor screening and MAGL activity assay kits, respectively. NGR1 prevented the development of PIMA in a dose-dependent manner. The docking scores showed that NGR1 has a good affinity for MAGL (−7.8 kcal/mol, binding energy) but less affinity than pristimerin (−10.3 kcal/mol). NGR1 inhibited the human recombinant MAGL activity in a reversible and concentration-dependent manner, although the inhibition was in a reverse order. Treatment of mice with NGR1 showed a non-significant trend in reducing the paclitaxel-induced increase in MAGL activity in the paw skin. This study shows for the first time that NGR1 prevents the development of PIMA and suggests that NGR1 has affinity for and inhibits human recombinant MAGL activity with a paradoxical inhibition pattern. More mechanistic studies are needed to fully elucidate the molecular mechanisms of NGR1 in preventing PIMA. Full article
(This article belongs to the Special Issue The Medicinal Value of Natural Products)
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Review

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15 pages, 4148 KB  
Review
Flavonoids and Other Phenolic Compounds for Physiological Roles, Plant Species Delimitation, and Medical Benefits: A Promising View
by Sompop Kuljarusnont, Satoshi Iwakami, Tsukasa Iwashina and Duangjai Tungmunnithum
Molecules 2024, 29(22), 5351; https://doi.org/10.3390/molecules29225351 - 14 Nov 2024
Cited by 11 | Viewed by 5811
Abstract
Flavonoids and other phenolic constituents are a large group of plant metabolites that have long attracted interest from researchers worldwide due to their functions in plant physiology, as well as their huge number of benefits for human health and well-being. This review attempts [...] Read more.
Flavonoids and other phenolic constituents are a large group of plant metabolites that have long attracted interest from researchers worldwide due to their functions in plant physiology, as well as their huge number of benefits for human health and well-being. This review attempts to reveal a promising view of the major physiological roles of flavonoids and other phenolic phytochemical molecules, e.g., protection agents against UV damage, pathogen defense agents, detoxifying agents, and agents promoting pollen fertility and successful pollination. Besides, the value of both flavonoids and other phenolic phytochemicals for plant species delimitation was also emphasized for the first time with the determination of their major physiological roles. Furthermore, their medical benefits for mankind were also highlighted in this current work. Full article
(This article belongs to the Special Issue The Medicinal Value of Natural Products)
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