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Special Issue "Advances and Future Perspective of Mass Spectrometry Analysis in Proteomics"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Prof. Dr. Fulvio Magni
E-Mail Website
Guest Editor
Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Vedano al Lambro, Italy
Interests: LC-MS; MALDI-imaging; biomarker discovery; phospho- and N-glycoproteome; cancer; glomerulonephrity
Dr. Marco Gaspari
E-Mail Website
Guest Editor
Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, 88100 Catanzaro, Italy
Interests: LC-MS; glycopeptide enrichment; biofluid proteomics; cancer proteomics; affinity purification-mass spectrometry (AP-MS)
Dr. Isabella Piga
E-Mail Website
Guest Editor
Department of Medicine and Surgery, Università degli Studi Milano-Bicocca, 20900 Vedano al Lambro, Italy
Interests: LC-MS; MALDI-imaging; biomarker discovery; method development; thyroid cancer

Special Issue Information

Dear Colleagues,

Over the last decade mass spectrometry technology has become an essential tool for proteomics research, and has been applied to a very wide range of areas such as protein profiling, protein identification and quantification, protein–protein interaction study, and post-translational modification characterization. Bottom-up (analysis of proteolytic peptide mixtures) and top-down (analysis of intact proteins) mass-spectrometry-based proteomics are the workhorse approaches to identify and characterize protein isoforms and post-translational modifications using a wide variety of sample types (i.e., cells, tissues, biofluids, food samples). A great deal of attention is paid to spatial proteomics, using mass spectrometry imaging approaches, which has paved the way for mapping the spatial localization of proteins maintaining tissue integrity, revolutionizing biomarker discovery. The phenomenal impact of mass-spectrometry-based proteomics on every field of research (from clinical study to forensic research, from environmental analysis to food analysis) is reflected in a continuous demand for novel sample preparation strategies and innovative workflow of analysis, and of statistical approaches able to process and interpret such big complex data sets.

In this context, it is a great pleasure to invite you to contribute to this Special Issue of Molecules, which will cover the latest research trends and applications in the field of mass spectrometry and proteomics, with full papers and communications describing original work as well as review articles. For review articles, a brief summary is required as a preliminary step to avoid overlapping topics.

Prof. Dr. Fulvio Magni
Dr. Marco Gaspari
Dr. Isabella Piga
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mass spectrometry
  • sample preparation
  • protein profiling
  • biomarker discovery
  • food proteomics
  • forensic proteomics
  • clinical proteomics
  • glycoproteomics
  • method optimization
  • method development
  • post-translational modifications
  • single cell proteomics
  • mass spectrometry imaging

Published Papers

This special issue is now open for submission.
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