Looking Closer to See Bigger: Challenges in Single-Cell Proteomics

Dear Colleagues,

Single-cell proteomics represents a new frontier in research opening up new possibilities in our quest to understand the complex biology behind pathological states. However, many challenges have yet to be overcome in single-cell analysis, both in terms of sample preparation methods and the management of big data. Working with single cells raises immediate concerns regarding protein quantities and concentrations. Moreover, with the advent of high-throughput and increasingly powerful technologies, single-cell analyses generate large datasets that can be difficult to manage and interpret. This Special Issue aims to untangle the challenges associated with single-cell proteomics and highlight recent advancements that have progressed the field. We invite you to contribute to this Special Issue of International Journal of Molecular Science and share your work on method development for sample preparation using both bottom-up and spatialOmics or new machine learning approaches enhancing data quality and biological interpretation.

This Special Issue is supervised by Dr. Isabella Piga and Dr. Andrew Smith, and assisted by our tap Dr. Giulia Capitoli (University of Milano-Bicocca).

Dr. Isabella Piga
Dr. Andrew Smith
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.