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Bioactive Molecules in Medicinal Plants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1246

Special Issue Editor


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Guest Editor
Laboratory of Pharmaceutical Biology and Biotechnology, Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medical Sciences, Collegium Pharmaceuticum, 3 Rokietnicka St., 60-806 Poznań, Poland
Interests: medicinal plants; plant biotechnology; in vitro cultures; secondary metabolites; pharmaceutical botany; phytochemistry

Special Issue Information

Dear Colleagues,

This Special Issue welcomes potential authors to contribute and share their original and review articles focusing on plant bioactive compounds. Contributions to this Special Issue may cover all research aspects related to medicinal plants—both those used in traditional medicine and those known pharmacopoeial raw materials—as well as potential species which may become a source of raw materials in the future. Research on the identification or isolation of compounds derived from medicinal plants growing in natural sites, cultivated in fields, or cultured in vitro will be accepted. Studies on the potential application of bioactive compounds are also welcome. In view of the medicinal potential of plants, the principal goals of this Special Issue focus on all aspects of phytochemical research, including the isolation and structural elucidation of the novel bioactive metabolites, biosynthesis, biotechnological methods enhancing the accumulation of bioactive compounds in plant tissues and other related research.

Dr. Małgorzata Kikowska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • identification and isolation of compounds
  • bioactivity of secondary metabolites
  • medicinal plants

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Published Papers (1 paper)

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Review

17 pages, 1870 KiB  
Review
The General Principle of the Warburg Effect as a Possible Approach for Cancer Immunotherapy: The Regulatory Effect of Plant Extracts Could Change the Game
by Donika Ivanova, Severina Semkova, Boncho Grigorov, Milena Tzanova, Ana Georgieva, Dancho Danchev, Biliana Nikolova and Zvezdelina Yaneva
Molecules 2025, 30(2), 393; https://doi.org/10.3390/molecules30020393 - 18 Jan 2025
Viewed by 1030
Abstract
The interpretation of the biochemistry of immune metabolism could be considered an attractive scientific field of biomedicine research. In this review, the role of glycolysis in macrophage polarization is discussed together with mitochondrial metabolism in cancer cells. In the first part, the focus [...] Read more.
The interpretation of the biochemistry of immune metabolism could be considered an attractive scientific field of biomedicine research. In this review, the role of glycolysis in macrophage polarization is discussed together with mitochondrial metabolism in cancer cells. In the first part, the focus is on the Warburg effect and redox metabolism during macrophage polarization, cancer development, and management of the immune response by the cancer cells. The second part addresses the possibility of impacts on the Warburg effect through targeting peroxisome proliferator-activated receptors (PPARs). This could be an activator of native immune responses. Because of the reported serious adverse effects of using synthetic ligands for PPARs in combination with chemotherapeutics, searches for less toxic and more active PPAR inhibitors, as well as blocking undesirable cellular PPAR-dependent processes, are in progress. On the other hand, recent research in modern immunotherapy has focused on the search for gentle immune-modulating natural compounds with harmless synergistic chemotherapeutic efficacy that can be used as an adjuvant. It is a well-known fact that the plant kingdom is a source of important therapeutic agents with multifaceted effectiveness. One of these is the known association with PPAR activities. In this regard, the secondary metabolites extracted from plants could change the game. Full article
(This article belongs to the Special Issue Bioactive Molecules in Medicinal Plants)
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