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New Insights into Bioactive Compounds from Natural Sources—Second Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 337

Special Issue Editors


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Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland
Interests: medicinal and aromatic plants; bioactive compounds; phytochemistry; antioxidants
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
Interests: plant biotechnology; medicinal plants; bioactive compounds; phytochemistry; essential oil; cytotoxic activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the success of the Special Issue titled "New Insights into Bioactive Compounds from Natural Sources", we are pleased to announce the launch of a second edition. We cordially invite you to submit original research papers or review articles for consideration in this upcoming publication.

Plants represent a rich source of specialized metabolites with diverse chemical structures that exhibit various biological activities. The beneficial properties of plants have been recognized for centuries, and interest in phytotherapy and natural food supplements continues to grow annually. Increasingly, researchers are investigating medicinal plants as an alternative and valuable source of natural compounds, which are considered safer and less/not toxic compared to synthetic pharmaceuticals. Plants hold considerable potential in the prevention and treatment of various diseases. By characterizing the chemical composition of plant extracts, it is possible to evaluate their safety and bioactivity, thus assessing their potential as natural therapeutic agents.

This Special Issue is open to high-quality original research and review articles that advance the knowledge of recent developments in bioactive plant metabolites. We welcome scientific contributions related to, but not limited to, the following topics:

This Special Issue is open to high-quality original research and review articles that advance the knowledge of recent developments in bioactive plant metabolites. We welcome scientific contributions related to, but not limited to, the following topics:

  • Biosynthesis of specialized metabolites in plants;
  • Isolation and identification of new molecules using modern chromatographic and spectral methods;
  • Qualitative and quantitative profiling of bioactive compounds in plant extracts;
  • Biotechnological strategies to increase the accumulation of phytochemicals in plant in vitro cultures;
  • Biological activity of pure compounds and plant extracts (in vitro and in vivo studies);
  • Structure of compounds and their bioactivity.

Dr. Agnieszka Kicel
Prof. Dr. Ewa Skała
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive plant-specialized metabolites
  • isolation and identification
  • bioactive compounds
  • qualitative and quantitative profiling
  • biotechnological strategies
  • biological activity
  • structure and bioactivity

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Published Papers (1 paper)

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Research

34 pages, 5631 KiB  
Article
Unveiling the Biotechnological Potential of Cyanobacteria from the Portuguese LEGE-CC Collection Through Lipidomics and Antioxidant and Lipid-Lowering Properties
by Flavio Oliveira, Tiago Conde, Marisa Pinho, Tânia Melo, Guilherme Scotta Hentschke, Ralph Urbatzka, Hugo Pereira, Monya Costa, Vitor Vasconcelos and Maria Rosário Domingues
Molecules 2025, 30(12), 2504; https://doi.org/10.3390/molecules30122504 (registering DOI) - 7 Jun 2025
Abstract
Cyanobacteria are filamentous, Gram-negative prokaryotic microorganisms composed of both broad morphological and phylogenetic diversity and inherited from diverse ecosystems like aquatic, terrestrial, or extremophilic environments. In this study, three cyanobacteria strains from the Blue Biotechnology and Ecotoxicology Culture Collection (LEGE-CC) were obtained from [...] Read more.
Cyanobacteria are filamentous, Gram-negative prokaryotic microorganisms composed of both broad morphological and phylogenetic diversity and inherited from diverse ecosystems like aquatic, terrestrial, or extremophilic environments. In this study, three cyanobacteria strains from the Blue Biotechnology and Ecotoxicology Culture Collection (LEGE-CC) were obtained from different environments in Portugal. Polyphasic analysis was applied for taxonomic identification. The proximate composition analysis indicated the lipid content (6.2% to 9.1% dry weight (DW)), protein content (28.2% to 62.9% DW), and carbohydrate content (19.5% to 46.1% DW). The fatty acid (FA) profiles of the strains revealed the presence of 19 different FAs, with FA 16:0 found in the highest abundance. The lipidomic analysis revealed 230 lipid species, with Laspinema sp. LEGE 06078 displaying the highest diversity (125 lipid species). These included species-specific and common lipids species that denote biochemical uniqueness that are also carriers of omega-3 FA (n−3). Biological assays exhibited strong antioxidant activity against ABTS•+ and DPPH in Laspinema sp. LEGE 06078, while Sphaerospermopsis sp. LEGE 00249 was renowned for reducing lipids in zebrafish larvae. The findings are of immense significance on the lipidomics diversity of cyanobacteria in terms of nutrition, health, and biotechnology, such as addressing obesity and sustainable resource production. Full article
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