Special Issue "Immunoconjugates for Cancer Imaging and Therapy"
Deadline for manuscript submissions: closed (15 August 2020).
Interests: design and synthesis of functional (photo) active (hybrid) materials based on porphyrins and phthalocyanines for: (i) photomedicine; (ii) photoinduced energy- and electron-transfer materials; (iii) optical (chemo)sensors; and (iv) (photo)catalysis
Special Issues and Collections in MDPI journals
Interests: glycoconjugates; immunoconjugates; anti-cancer agents; PET imaging; photodynamic therapy; radiation therapy
Monoclonal antibodies (mAbs), with a high affinity for cancer cell surface antigens, are the most attractive biomolecules as diagnostics and therapeutics in oncology. Since the development of hybridoma technology, in 1975, several antibodies have been developed against either validated or novel tumor antigens overexpressed or selectively expressed on cancer cells.
Antibodies conjugated with drugs incorporate the high affinity/specificity of the mAb with the cytotoxicity of the drug and therefore selectively destroy tumor cells. On the other hand, optical- and radionuclide-labeled antibodies generate images with an intensity proportional to the amount of antibody-targeted tumor-antigen, allowing disease diagnosis and staging, and detection of tumor recurrence.
The present Special Issue on “Immunoconjugates for Cancer Imaging and Therapy” welcomes articles reporting original discoveries and reviews in the context of antibody–drug conjugates and optical- and radionuclide-labeled antibodies to be used as therapeutics and diagnostics in oncology.
Prof. Dr. João Paulo C. Tomé
Prof. Jason S. Lewis
Dr. Patricia Pereira
Manuscript Submission Information
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