molecules-logo

Journal Browser

Journal Browser

Pharmacological Effects of Natural Products: Antioxidant, Anti-Inflammatory and Anticancer Activities

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 865

Special Issue Editors


E-Mail Website
Guest Editor
Grupo Infección e Inmunidad, Departamento de Ciencias Básicas, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira 660003, Colombia
Interests: immunology of infectious diseases; immunomodulation by natural products; regenerative medicine; tissue engineering; arboviruses; SARS-CoV-2; metabolomics

E-Mail Website
Guest Editor
Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo 83000, Mexico
Interests: evaluation of the biological activity of natural products of medicinal plants; isolation and chemical characterization of bioactive compounds of medicinal plants

Special Issue Information

Dear Colleagues,

The use of natural products and their active components has been the basis for discovering molecules with therapeutic activity in humans. The search for extracts and molecules of natural origin with potential antioxidant and anti-inflammatory activity has recently increased. Additionally, given that cancer is considered a chronic inflammatory disease, where the phenomenon of oxidative stress has been demonstrated, extracts or molecules with antioxidant and anti-inflammatory activity can be considered to have potential anticancer activity. Understanding the mechanisms responsible for the biological activity of extracts and molecules of natural origin will facilitate the development of new therapeutic strategies for treating inflammatory diseases such as atopic dermatitis, allergic rhinitis, allergic asthma, asthma, COPD, inflammatory bowel disease and cancer.

This Special Issue is designed to present research conducted in relation to products of natural origin, their constituents and their pharmacological activities. We welcome submissions that address, but are not limited to, the following areas: the identification and characterization of bioactive compounds from terrestrial, marine, and endophytic plant sources and pharmacological studies on the efficacy, mechanism of action and safety of natural medicines and their active components. Structural modifications of natural products are made to increase their pharmacological activity and reduce toxicity to develop more effective and safer therapeutic agents. Manuscripts should be original, unpublished works or reviews that contribute to understanding the pharmacological activities of natural constituents. They should be well structured, clearly written, and supported by rigorous experimental data. All the submissions will undergo a peer-review process to ensure the highest quality scientific standards.

Dr. Juan Carlos Sepúlveda-Arias
Dr. Ramón Enrique Robles Zepeda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • plant extracts
  • phytochemical inflammatory diseases
  • oxidative stress
  • cancer
  • biological activity
  • drug discovery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

27 pages, 9169 KiB  
Review
Bioactive Molecules from Tropical American Plants: Potential Anti-Inflammatory Agents for Cytokine Storm Management
by Erika Plazas, Lucellys Sierra-Marquez and Jesus Olivero-Verbel
Molecules 2025, 30(7), 1486; https://doi.org/10.3390/molecules30071486 - 27 Mar 2025
Viewed by 368
Abstract
The cytokine storm, a hyperinflammatory response characterized by the excessive release of pro-inflammatory mediators such as TNFα, INFγ, IL-1β, IL-6, and GM-CSF, has been identified as a critical factor in the progression and severity of acute inflammatory conditions. Regulating these pathways is essential [...] Read more.
The cytokine storm, a hyperinflammatory response characterized by the excessive release of pro-inflammatory mediators such as TNFα, INFγ, IL-1β, IL-6, and GM-CSF, has been identified as a critical factor in the progression and severity of acute inflammatory conditions. Regulating these pathways is essential for mitigating systemic damage and improving outcomes. Natural products from tropical American plants have shown significant potential in modulating these hyperinflammatory responses. Key polyphenols, like quercetin and luteolin, found in plants such as Achyrocline satureioides and Mangifera indica demonstrate the downregulation of NF-κB and inhibition of pro-inflammatory cytokines. Alkaloids, such as berberine and mitraphylline, isolated from Berberis species and Uncaria tomentosa, respectively, have shown potent effects in suppressing nitric oxide production and regulating inflammasomes. Terpenoids, including parthenolide from Tanacetum parthenium and curcumol from Curcuma longa, exhibit multitarget activity, reducing cytokine levels and inhibiting key inflammatory enzymes like COX-2 and iNOS. These findings highlight the immense potential of bioactive compounds from tropical American plants as modulators of immune–inflammatory pathways, providing a foundation for developing effective therapeutic agents to counteract the severe effects of cytokine storms. Full article
Show Figures

Figure 1

26 pages, 3572 KiB  
Review
Biological Activity of Monoterpene-Based Scaffolds: A Natural Toolbox for Drug Discovery
by Jarosław Mołdoch, Monika Agacka-Mołdoch, Grzegorz Jóźwiak and Karolina Wojtunik-Kulesza
Molecules 2025, 30(7), 1480; https://doi.org/10.3390/molecules30071480 - 27 Mar 2025
Viewed by 411
Abstract
One of the most common strategies used in drug design is the molecular scaffold approach, which combines traditional medicine based on natural active compounds derived from plants with modern synthetic drug development. Designing new compounds based on natural skeletons enables extensive modifications of [...] Read more.
One of the most common strategies used in drug design is the molecular scaffold approach, which combines traditional medicine based on natural active compounds derived from plants with modern synthetic drug development. Designing new compounds based on natural skeletons enables extensive modifications of both bioavailability and biological activity. An excellent example of a natural molecular scaffold is the monoterpenes group, which serves as a core structure for building more complex molecules by attaching various chemical groups. Their ability to interact with biological targets, combined with structural versatility, makes them promising molecular scaffolds in pharmaceutical research and green chemistry applications. This review paper focuses on selected monoterpenes (carvacrol, carvone, citral, menthol, menthone, β-pinene, thymol, and verbenone), which are frequently used as molecular scaffolds. The newly designed derivatives exhibit various biological activities, including anticancer, antibacterial, antiviral, neuroprotective, and many others. Full article
Show Figures

Figure 1

Back to TopTop