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Special Issue "DNA/RNA G-quadruplex"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (30 September 2020).

Special Issue Editor

Prof. Dr. Yan Xu
E-Mail Website
Guest Editor
Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
Interests: biochemistry; bioorganic chemistry; DNA; RNA; telomere; G-quadruplex

Special Issue Information

Dear Colleagues,

DNA/RNA G-quadruplexes are formed by the stacking of several G-tetrads and are constituted by four backbone strands connected by several loops. In recent years, these noncanonical structures have been suggested to be involved in various genome dynamics, such as transcription, replication, translation, recombination, higher-order chromosome structure, telomere regulation, epigenome regulation, etc. The related proteins of DNA/RNA G-quadruplexes are involved in important biological functions. Many G-quadruplexes are considered to be attractive molecular targets for cancer therapeutics. Recently, some small molecules and antibodies have been used to investigate G-quadruplex structures. Furthermore, G-quadruplexes are finding applications in nanotechnology as nanomaterials, mechanical devices, and biosensors. This Special Issue aims to provide an overview of the advances in understanding of the structures and functions of DNA/RNA G-quadruplexes, and the current efforts on developing various chemical probes, nanomaterials, and biosensors in G-quadruplexes.

Prof. Yan Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • DNA/RNA G-quadruplex structures
  • DNA/RNA G-quadruplex functions
  • chemical probes for DNA/RNA G-quadruplexes
  • related proteins of DNA/RNA G-quadruplexes
  • nanotechnology and nanomaterials in G-quadruplexes

Published Papers (1 paper)

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Research

Communication
Effect of Distance from Catalytic Synergy Group to Iron Porphyrin Center on Activity of G-Quadruplex/Hemin DNAzyme
Molecules 2020, 25(15), 3425; https://doi.org/10.3390/molecules25153425 - 28 Jul 2020
Viewed by 762
Abstract
G-quadruplex/Hemin (G4/Hemin) complex has been widely used in biocatalysis and analytical applications. Meanwhile, compared with natural proteinous enzyme, its low catalytic activity is still limiting its applications. Even though several methods have been developed to enhance the peroxidation efficiency, the important core of [...] Read more.
G-quadruplex/Hemin (G4/Hemin) complex has been widely used in biocatalysis and analytical applications. Meanwhile, compared with natural proteinous enzyme, its low catalytic activity is still limiting its applications. Even though several methods have been developed to enhance the peroxidation efficiency, the important core of the G4 design based enhancement mechanism is still indistinct. Here, we focus the mechanism study on the two most important microdomains: the iron porphyrin center and the catalytic synergy group within the 3′ flanking. These microdomains not only provide the pocket for the combination of substrate, but also offer the axial coordination for the accelerated formation of Compound I (catalytic intermediate). In order to obtain a more suitable space layout to further accelerate the catalytic process, we have used the bases within the 3′ flanking to precisely regulate the distance between microdomains. Finally, the position-dependent effect on catalytic enhancement is observed. When dC is positioned at the second-position of 3′ flanking, the newly obtained DNAzyme achieves an order of magnitude improvement compared to parent G4/Hemin in catalytic activity. The results highlight the influence of the distance between the catalytic synergy group and iron porphyrin center on the activity of DNAzyme, and provide insightful information for the design of highly active DNAzymes. Full article
(This article belongs to the Special Issue DNA/RNA G-quadruplex)
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