Special Issue "DNA/RNA G-quadruplex"
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 1430
Interests: biochemistry; bioorganic chemistry; bio-orthogonal chemistry; DNA; RNA; telomere; G-quadruplex
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DNA/RNA G-quadruplexes are formed by the stacking of several G-tetrads and are constituted by four backbone strands connected by several loops. In recent years, these noncanonical structures have been suggested to be involved in various genome dynamics, such as transcription, replication, translation, recombination, higher-order chromosome structure, telomere regulation, epigenome regulation, etc. The related proteins of DNA/RNA G-quadruplexes are involved in important biological functions. Many G-quadruplexes are considered to be attractive molecular targets for cancer therapeutics. Recently, some small molecules and antibodies have been used to investigate G-quadruplex structures. Furthermore, G-quadruplexes are finding applications in nanotechnology as nanomaterials, mechanical devices, and biosensors. This Special Issue aims to provide an overview of the advances in understanding of the structures and functions of DNA/RNA G-quadruplexes, and the current efforts on developing various chemical probes, nanomaterials, and biosensors in G-quadruplexes.
Prof. Yan Xu
Manuscript Submission Information
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- DNA/RNA G-quadruplex structures
- DNA/RNA G-quadruplex functions
- chemical probes for DNA/RNA G-quadruplexes
- related proteins of DNA/RNA G-quadruplexes
- nanotechnology and nanomaterials in G-quadruplexes