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Marine Drugs
Special Issues
Marine Streptomyces-Derived Natural Products 2024
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Marine Streptomyces-Derived Natural Products 2024

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 7025

Special Issue Editors

Dr. Sang-Jip Nam

E-Mail Website
Guest Editor
Department of Chemistry and Nano Science, College of Natural Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea
Interests: marine natural products; structure elucidation of natural products; antibacterial and anti-cancer natural products
Special Issues, Collections and Topics in MDPI journals
Dr. Dong-Chan Oh

E-Mail Website
Guest Editor
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
Interests: marine actinomycetes; natural products; NMR; structure elucidation; antibiotics; symbiosis; biosynthesis; genomics
Special Issues, Collections and Topics in MDPI journals
Dr. Inho Yang

E-Mail Website
Guest Editor
Ocean Science & Technology School, Korea Maritime and Ocean University, Busan 49112, Republic of Korea
Interests: bioactivity natural product; chemistry; chromatography; medicinal and pharmaceutical chemistry; phytochemicals; extraction; antimicrobials; antioxidant activity

Special Issue Information

Dear Colleagues,

It is widely acknowledged that marine microorganisms possess considerable potential as sources of bioactive natural products. Streptomyces, a principal subdivision of Actinobacteria, has been the subject of extensive investigation for its novel secondary metabolites. This fertile microbial genus accounts for over 80% of actinomycete natural products and approximately 50% of all known antibiotics.

Therefore, Streptomyces strains derived from marine-related environments require attention from researchers. More specifically, the most recent advanced approaches demand a thorough examination, such as an isolation strategy for the bioactive metabolites producing Streptomyces strains, applications of the metabolites based on their wide range of bioactivities, and the chemical structure elucidation of marine microbial secondary metabolites. This Special Issue is dedicated to studying the inherent potential of these microorganisms as an abundant reservoir of marine natural products.

Dr. Sang-Jip Nam
Dr. Dong-Chan Oh
Dr. Inho Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine streptomyces
  • marine natural product
  • chemical structure elucidation
  • bioactive secondary metabolite
  • drug hit/lead discovery

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Published Papers (5 papers)

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Research

9 pages, 1438 KiB  
Communication
Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived Streptomyces sp. HDN150000
by Xiaoting Zhang, Falei Zhang, Wenxue Wang, Xingtao Ren, Tianjiao Zhu, Qian Che, Dehai Li and Guojian Zhang
Mar. Drugs 2025, 23(5), 188; https://doi.org/10.3390/md23050188 - 27 Apr 2025
Viewed by 282
Abstract
Three new structures named naphpyrone I–K (1–3) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived Streptomyces sp. HDN155000. Their chemical structures, including configurations, were elucidated by extensive NMR, MS, single-crystal X-ray diffraction, theoretical [...] Read more.
Three new structures named naphpyrone I–K (1–3) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived Streptomyces sp. HDN155000. Their chemical structures, including configurations, were elucidated by extensive NMR, MS, single-crystal X-ray diffraction, theoretical NMR calculations, DP4+ probability analysis, and ECD analyses. Naphpyrone K (3) showed cytotoxic activities against L-02, K562, NCI-H446/EP, MDA-MB-231, and NCI-H446 cancer cells with IC50 values of 5.13, 3.34, 2.50, 2.61, and 2.20 μM, respectively. These findings highlight the potential for screening and developing therapeutic drugs from aromatic polyketides derived from marine actinobacteria. Full article
(This article belongs to the Special Issue Marine Streptomyces-Derived Natural Products 2024)
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22 pages, 4278 KiB  
Article
In Vitro and In Silico Studies on the Anti-H1N1 Activity of Bioactive Compounds from Marine-Derived Streptomyces ardesiacus
by Yung-Husan Chen, Cheng-Yang Hsieh, Chun-Tang Chiou, Engelo John Gabriel V. Caro, Lemmuel L. Tayo and Po-Wei Tsai
Mar. Drugs 2025, 23(4), 149; https://doi.org/10.3390/md23040149 - 29 Mar 2025
Viewed by 407
Abstract
This study explores the potential anti-H1N1 Influenza A activity of bioactive compounds extracted from Streptomyces ardesiacus, a marine-derived microorganism known for producing diverse secondary metabolites. Four major compounds—1-acetyl-β-carboline, 1H-indole-3-carbaldehyde, anthranilic acid, and indole-3-carboxylic acid—were isolated and characterized through NMR. Among [...] Read more.
This study explores the potential anti-H1N1 Influenza A activity of bioactive compounds extracted from Streptomyces ardesiacus, a marine-derived microorganism known for producing diverse secondary metabolites. Four major compounds—1-acetyl-β-carboline, 1H-indole-3-carbaldehyde, anthranilic acid, and indole-3-carboxylic acid—were isolated and characterized through NMR. Among these, the identified structure of 1-acetyl-β-carboline showed the highest IC50 effect, with a dose of 9.71 μg/mL in anti-influenza assays. Using network pharmacology and molecular docking analyses, the interactions of these compounds with key proteins involved in H1N1 pathogenesis were examined. Protein–protein interaction (PPI) networks and Gene Ontology enrichment analysis revealed CDC25B, PARP1, and PTGS2 as key targets, associating these compounds with pathways related to catalytic activity, inflammation, and cell cycle regulation. The molecular docking results demonstrated that 1-acetyl-β-carboline exhibited binding affinities comparable to Tamiflu, the positive control drug, with LibDock scores of 81.89, 77.49, and 89.21 for CDC25B, PARP1, and PTGS2, respectively, compared to Tamiflu’s scores of 84.34, 86.13, and 91.29. These findings highlight the potential of the active compound 1-acetyl-β-carboline from S. ardesiacus as a novel anti-influenza agent, offering insights into their molecular mechanisms of action. The results support further in vitro and in vivo studies to validate the observed inhibitory mechanisms and therapeutic applications against H1N1 Influenza A. Full article
(This article belongs to the Special Issue Marine Streptomyces-Derived Natural Products 2024)
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Figure 1

11 pages, 1411 KiB  
Article
Genome-Based Mining of Carpatamides I–M and Their Candidate Biosynthetic Gene Cluster
by Shu-Mei Shen, Yun-Chang Xie, Li-Rong Tu, Miao-Er Wu, Yan-Min Wang, Chun-Hui Song, Yu-Hui Sun and Ming-He Luo
Mar. Drugs 2024, 22(11), 521; https://doi.org/10.3390/md22110521 - 20 Nov 2024
Cited by 1 | Viewed by 1133
Abstract
Chemically investigating the marine-derived Streptomyces parvus 1268 led to the isolation of a new compound of carpatamide I (1). Subsequent genomic analysis identified its candidate biosynthetic gene cluster ctd of approximately 44 kb. In order to obtain more carpatamide derivatives, we [...] Read more.
Chemically investigating the marine-derived Streptomyces parvus 1268 led to the isolation of a new compound of carpatamide I (1). Subsequent genomic analysis identified its candidate biosynthetic gene cluster ctd of approximately 44 kb. In order to obtain more carpatamide derivatives, we conducted the upregulation of Ctd14, which is a positive regulator, and obtained improvement of carpatamide I and four new compounds of carpatamides J–M (2–5). The structures of the aforementioned five new isolates were identified by a combination of ESI-HRMS as well as one-dimensional (1D) and two-dimensional (2D) spectral NMR datasets. Bioassay results showed that compounds 1–5 displayed anti-inflammatory activity and weak cytotoxicity against cell lines of A549, HT-29, and HepG2. Full article
(This article belongs to the Special Issue Marine Streptomyces-Derived Natural Products 2024)
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11 pages, 1552 KiB  
Article
Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751
by Jiaming Yu, Hui Guo, Jing Zhang, Jiansen Hu, Hongtao He, Caixia Chen, Na Yang, Fan Yang, Zexu Lin, Huanqin Dai, Liming Ouyang, Cuihua Liu, Xiaoguang Lei, Lixin Zhang, Guoliang Zhu and Fuhang Song
Mar. Drugs 2024, 22(6), 259; https://doi.org/10.3390/md22060259 - 3 Jun 2024
Viewed by 1644
Abstract
A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6 [...] Read more.
A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains. Full article
(This article belongs to the Special Issue Marine Streptomyces-Derived Natural Products 2024)
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Figure 1

13 pages, 4201 KiB  
Article
Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells
by Sultan Pulat, Inho Yang, Jihye Lee, Sunghoon Hwang, Rui Zhou, Chathurika D. B. Gamage, Mücahit Varlı, İsa Taş, Yi Yang, So-Yeon Park, Ahreum Hong, Jeong-Hyeon Kim, Dong-Chan Oh, Hangun Kim, Sang-Jip Nam and Heonjoong Kang
Mar. Drugs 2024, 22(2), 88; https://doi.org/10.3390/md22020088 - 14 Feb 2024
Cited by 2 | Viewed by 2841
Abstract
Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined [...] Read more.
Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells. Full article
(This article belongs to the Special Issue Marine Streptomyces-Derived Natural Products 2024)
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