Drug Metabolism and Pharmacokinetics: Current Trends and Future Perspectives

Dear Colleagues,

Adequate information on systemic exposure to a drug is a critical factor in the development process. It is essential for newly designed drugs and finding the clinical proof for traditionally used remedies' efficacy. Besides, assessment of pharmacokinetics of the active pharmaceutical ingredients enables the prediction of the therapeutic success, from animal models to phase III clinical trials. Moreover, a detailed pharmacokinetic analysis often leads to discovering the causes of an inadequate response to the drug. For example, the drug exposure might be lower due to the insufficient activity of one of the enzymes in the metabolic pathway.

The cornerstone of pharmacokinetics is an accurate determination of the active moieties in collected samples. For this purpose, the researchers aim to develop the most precise and accurate analytical methods. Undeniably, the benchmark is mass spectrometry methods, which are deemed as the most sensitive. However, alternative approaches such as immunoenzymatic methods are also considered, mainly due to time and cost efficiency.

This Special Issue focuses on the development and application of bioanalytical methods for pharmacokinetic analysis. Submitted manuscripts should focus on one of the following aspects:

• Highlighting the advantage of the novel method over currently used ones,
• Comparison of bioanalytical approaches for determination of pharmaceutical ingredients in biological matrices,
• Application of the method for establishing pharmacokinetics of a novel pharmaceutical ingredient or herbal extracts,
• Application of the method for a better understanding of drug metabolism and disposition.

Prof. Dr. Satomi Onoue
Dr. Dorota Danielak
Dr. Katarzyna Kosicka-Noworzyń
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.