Dendrimers as Nanocarriers for Drug Delivery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (1 September 2019) | Viewed by 2936
Special Issue Editor
Interests: computer-aided molecular design; molecular dynamics; computational chemistry; protein–ligand interactions; protein–excipient interactions; formulation design; NMR spectroscopy; antimicrobial peptide modelling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Medicines development research strives to improve drug efficacy and effectiveness via the optimization of drug delivery to achieve controlled release at the target site. The use of nanocarriers can improve the bioavailability of drugs and, at the same time, circumvent problems associated with their off-target interactions. These novel delivery systems offer opportunities to expand the spectrum of biomedical applications of molecules with poor drug-like properties.
Dendrimers, branched polymers with their highly tunable three-dimensional structure and modifiable surface functionalities, are attractive systems for drug delivery due to the possibility to build multifunctional nanocarriers for the targeted and smart release of the active pharmaceutical ingredient. The structure of the dendrimers can be varied to accommodate different molecules and/or to target different tissues, while the choice of monomers, number of generations, and surface modifications can be guided by computational chemistry approaches. Exploiting this versatile molecular architecture can unlock almost unlimited potential applications of dendrimers for the treatment of many diseases.
This Special Issue aims to attract contributions covering all fields concerning the development of dendrimers as nanocarriers, including the rational design of novel dendrimers as delivery systems, their synthesis with challenges in characterization, and their biomedical applications.
Honorary Prof. Dr. Mire Zloh
Guest Editor
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Keywords
- Dendrimers
- Dendrons
- Drug delivery
- Drug encapsulation
- Drug targeting
- Dendrimer drug interactions
- Controlled release
- pH-responsive nanocarriers
