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Stable Deuterium Labeling of Histidine-Rich Lysine-Based Dendrimers

Saint Petersburg State University, 7/9 Universitetskaya nab, 199034 Saint Petersburg, Russia
Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoi Prospect 31, V.O., 199004 Saint Petersburg, Russia
Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), Kronverkskiy pr. 49, 197101 Saint Petersburg, Russia
Department of Physics, LUT University, Box 20, 53851 Lappeenranta, Finland
Author to whom correspondence should be addressed.
Molecules 2019, 24(13), 2481;
Received: 15 June 2019 / Revised: 2 July 2019 / Accepted: 4 July 2019 / Published: 6 July 2019
(This article belongs to the Special Issue Dendrimers as Nanocarriers for Drug Delivery)
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Peptide dendrimers, due to their biocompatibility and low toxicity, are highly promising candidates as nanocarriers for drugs and genes. The development of this kind of delivery system requires reliable monitoring of their metabolic and biological pathways. In this respect, hydrogen isotope labeling has tremendous importance, being a safe tool for detection of the labeled nanocarriers. In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment. The presence of His residues has enabled us to perform controlled deuteration of Lys-2His dendrimers. The high deuteration degree (around 70%) does not practically change after redissolving the samples in H2O and heating them at 40 °C, which indicates the isotopic label stability. View Full-Text
Keywords: peptide dendrimer; deuterium labeling; histidine peptide dendrimer; deuterium labeling; histidine

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Sheveleva, N.N.; Markelov, D.A.; Vovk, M.A.; Tarasenko, I.I.; Mikhailova, M.E.; Ilyash, M.Y.; Neelov, I.M.; Lahderanta, E. Stable Deuterium Labeling of Histidine-Rich Lysine-Based Dendrimers. Molecules 2019, 24, 2481.

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