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Metal Complexes and Their Medicinal Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 15 November 2026 | Viewed by 2127

Special Issue Editor


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Guest Editor
School of Health & Medical Sciences, Vizja University in Warsaw, Okopowa 59, 01-043 Warsaw, Poland
Interests: gamma radiation; electron beam radiation; polymer materials; medical device polymers; polymer characterization; biomedical polymers; biopolymers; coordination compounds; radiation modification; oxidative stress; free radicals; antioxidants; structural biology; material testing
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Special Issue Information

Dear Colleagues,

Metal complexes have become central to modern medicinal chemistry, where advances over the past 10–15 years have revealed how controlled coordination, redox activity, and structural tunability can be leveraged for targeted therapy, imaging, and diverse biological interventions. Developments in ligand engineering, nanotechnology, and molecular targeting have produced metal-based agents with greatly improved specificity, efficacy, and safety, supporting applications in cancer treatment, antimicrobial therapy, diagnostic imaging, enzyme modulation, and other emerging biomedical uses. Alongside these core medical applications, this issue also opens a space to consider emerging uses in supplements and clinical nutrition.

Dr. Hanna Lewandowska
Guest Editor

Manuscript Submission Information

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Keywords

  • metal complexes
  • medicinal chemistry
  • anticancer agents
  • antimicrobial activity
  • diagnostic imaging
  • therapeutic design
  • coordination chemistry
  • supplements
  • clinical dietetics

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Published Papers (2 papers)

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Review

31 pages, 4321 KB  
Review
Applications of Carbon Dots and Graphene Quantum Dots in Treatment of Diabetes
by Sho Nakayama, Eric J. Shepard, Abhinandan Banerjee, Xiaoda Yang and Debbie C. Crans
Molecules 2026, 31(6), 941; https://doi.org/10.3390/molecules31060941 - 11 Mar 2026
Cited by 1 | Viewed by 758
Abstract
Carbon nanoparticles (CNPs) are increasingly being considered for medical applications. The objective of this article is to determine which anti-diabetic drugs and compounds have been enhanced by CNPs, and which CNP scaffolds were found to be successful. The anti-diabetic drugs administered loaded on [...] Read more.
Carbon nanoparticles (CNPs) are increasingly being considered for medical applications. The objective of this article is to determine which anti-diabetic drugs and compounds have been enhanced by CNPs, and which CNP scaffolds were found to be successful. The anti-diabetic drugs administered loaded on CNPs include insulin, metformin, glimepiride and vanadium compounds. Carbon quantum dots (CQDs), graphene quantum dots (GQDs), graphene oxide quantum dots (GOQDs), hybrid systems and fullerenes are all carriers able to alleviate symptoms of diabetes. Successful CNPs are 10 nm or less and can have a flat pancake structure, as well as the spherical CQDs and the spherical-but-hollow gadofullerene (Gd-C82). The use of the carbon nanoparticle scaffold includes oral, intravenous administration and placement as an implant in a diabetic animal model system. In vitro studies in an insulin-resistant model demonstrate a 500–1000-fold enhancement of metformin when placed on the pegylated GOQD. Although some CNPs have low toxicity, more information is needed for understanding the metabolism associated with uptake and processing. In summary, CNPs represent a novel class of nanoparticles that has promising potential. They enhance the efficacy of anti-diabetic drugs, have low toxicity, and keep the loaded drug protected until reaching their targets. Full article
(This article belongs to the Special Issue Metal Complexes and Their Medicinal Applications)
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35 pages, 1665 KB  
Review
Towards the Development of Effective Antioxidants—The Molecular Structure and Properties—Part 2
by Hanna Lewandowska, Renata Świsłocka, Waldemar Priebe, Włodzimierz Lewandowski and Sylwia Orzechowska
Molecules 2026, 31(4), 720; https://doi.org/10.3390/molecules31040720 - 19 Feb 2026
Cited by 1 | Viewed by 1113
Abstract
The development of effective antioxidants has evolved from descriptive analysis toward a precise, mechanism-driven discipline targeting the molecular “redox switch”. This review synthesizes the critical advances reported since 2021, focusing on how the interplay between polyphenolic architecture and electronic descriptors, such as bond [...] Read more.
The development of effective antioxidants has evolved from descriptive analysis toward a precise, mechanism-driven discipline targeting the molecular “redox switch”. This review synthesizes the critical advances reported since 2021, focusing on how the interplay between polyphenolic architecture and electronic descriptors, such as bond dissociation enthalpy and ionization potential, governs radical scavenging through the HAT, SET, and SPLET pathways. We evaluate the dual influence of metal coordination, where interactions can either enhance antioxidant stability through σ bond polarization or trigger pro-oxidant transitions via ligand-to-metal charge transfer. Central to this progress is the integration of computational models (DFT, QSAR) with advanced synchrotron methodologies (XAS, STXM, SR-FTIR, and SAXS), which provide element-specific validation of antioxidant behavior and subcellular oxidative mapping within complex matrices. Furthermore, we highlight how these molecular insights inform formulation engineering, specifically the development of organic nanocarriers and hybrid delivery systems, such as metal–phenolic networks, that shield therapeutic cargo from degradation and govern release in challenging physiological environments. These fundamental studies provide an essential physicochemical basis for medicine by enabling a better understanding and the rational design of antioxidant drugs, dietary supplements, and antioxidant strategies. Full article
(This article belongs to the Special Issue Metal Complexes and Their Medicinal Applications)
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